Suboptimal intake of dietary zinc (Zn) is one the most common nutritional problems worldwide. Previously, authors have shown that deficiency (ZD) produces oxidative and nitrosative stress in lung male rats. The goal this study to test effect moderate ZD on insulin-like growth factor (IGF)-1, IGF-binding protein (IGFBP)-5, NADH oxidase (NOX)-2, tumor necrosis alpha (TNFα), as well restoring during refeeding period. Adult rats were divided into 3 groups: Zn-adequate control group, Zn-deficient...

Reactive arthritis (ReA) is a type of originating from certain gastrointestinal or genitourinary infections. In previous studies, we reported the development progressive Yersinia enterocolitica-induced ReA in mice lacking TNFR p55; however, mechanisms underlying this effect are still uncertain. study, investigated impact p55 deficiency modulating Ag-specific Th1 and Th17 responses during arthritogenic process. We found more severe TNFRp55(-/-) compared with their wild-type (WT) counterparts....

Lactation deficiency may have important consequences on infant health, particularly in populations of low socioeconomic status. The OFA hr/hr (OFA) strain rats, derived from Sprague–Dawley (SD) has deficient lactation and is a good model failure. We examined the reproductive performance hormonal profiles SD strains to determine cause(s) failure strain. measured (PRL, GH, gonadotropins, oxytocin, progesterone) levels by RIA cycling, pregnant, lactating rats response suckling. Dopaminergic...

<i>Background/Aims:</i> During late pregnancy, the antiprogesterone mifepristone facilitates prolactin release. This effect is enhanced by administration of opioid antagonist naloxone, suggesting an inhibitory-neuromodulatory role system. Since hypothalamic dopamine (DA) main regulator release, in this study we explored DA on release induced and naloxone treatment. <i>Methods/Results:</i> Rats day 19 pregnancy were used. Naloxone treatment did not modify...

Suboptimal intake of Zn is one the most common nutritional problems worldwide. Previously, we have shown that deficiency (ZD) produces oxidative and nitrosative stress in lung rats. We analyse effect moderate ZD on expression several intermediate filaments cytoskeleton, as well restoring during refeeding period. Adult male rats were divided into three groups: Zn-adequate control (CO) group; Zn-refeeding group. CerbB-2 proliferating cell nuclear antigen (PCNA) was increased group while other...

Background: Progesterone (P4) is the main steroid secreted by corpora lutea (CL) and required for successful implantation maintenance of pregnancy. Although adequate circulating levels thyroid hormone (TH) are needed to support formation CL during pregnancy, TH signaling had not been described in this gland. We determined luteal receptor isoforms (TR) expression regulation throughout pregnancy under influence status, vitro effects triiodothyronine (T3) exposure on P4 synthesis. Methods:...

Abstract We assessed immunoreactivity (IR) in the cerebral cortex (CC), hippocampus (Hipp), and striatum (ST) of a growth‐associated protein, GAP‐43, proteins synaptic vesicle fusion complex: VAMP‐2, Syntaxin‐1, SNAP‐25 (SNARE proteins) throughout postnatal development rats after submitting animals to acute global hypoxia (6.5% O 2 , 70 min) at day 4 (PND4). In CC only IR SNARE protein increased significantly with age. The hypoxic showed same pattern for SNAP‐25, although lower levels PND11,...

OFA hr/hr (OFA) rats present a major lactation deficit that impairs offspring survival. To explore whether abnormal stress responsiveness causes this deficit, we compared their hormonal (prolactin, progesterone, and corticosterone) responses to (room change 2-min ether exposure) with those of Wistar Sprague Dawley (SD) rats. We tested during the estrous cycle, pregnancy, lactation, after ovariectomy, ovarian steroid hormone priming, suckling. evaluated hypothalamic expression receptors for...

The pathogenesis of reactive arthritis (ReA), an aseptic synovitis that follows extra-articular infection, is incompletely known. We studied the impact tumour necrosis factor receptor (TNFR) p55 deficiency on progression to ReA after oral Yersinia enterocolitica O:3 antigens triggering articular inflammation and a possible TNFRp55-mediated mechanism protects against ReA.Wild-type C57BL/6 TNFRp55-/- mice were orogastrically infected with Y. monitored for survival development. bacterial load...

In addition to its well‐known pro‐inflammatory effects, tumor necrosis factor (TNF) displays anti‐inflammatory activities through mechanisms poorly understood. Previously, we reported the development of severe chronic Yersinia enterocolitica‐ induced reactive arthritis (ReA) in mice lacking TNF receptor (TNFR)p55. As regulatory T (T reg ) cells limit inflammation, here aim investigate expansion and function CD4 + CD25 FoxP3 ReA animal model. The number as well mRNA expression interleukin...

Mammary stroma is composed of various cell types, including migratory leukocytes. Although mammary antibody-secreting cells have been extensively studied, reports focusing on T are scarce. It thought that the recruitment mechanism leukocytes to gland (MG) controlled by pregnancy- and lactation-specific stimuli. But whether prolactin (PRL) modulates T-cell population in MG still unknown. Our aim was study relationship between PRL levels B during early lactation (L2, day 2 post partum)...

Nanotechnology is providing new tools for precision agriculture, such as agrochemical agents and innovative delivery mechanisms to improve cropping efficiency. Powder nanoinsecticides, experimental nanostructured alumina (NSA), show great potential sustainable agriculture an alternative conventional synthetic pesticides because their mechanism of insecticide action based on physical rather than biochemical phenomena. However, even in highly non-reactive hardly soluble substances alumina,...

<i>Background/Aims:</i> Progesterone (P<sub>4</sub>) fall provoked by spontaneous or prostaglandin F2α (PGF2α)-induced luteolysis in late pregnant rats triggers a prolactin (PRL) surge 12–24 h later. <i>Methods:</i> To investigate the hypothalamic mechanism mediating this response, we determined expression of tyrosine hydroxylase (TH), PRL receptors (long form, PRLR<sub><i>long</i></sub>), estrogen-α (ERα) and ERβ,...