A5090978891- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Cancer-related molecular mechanisms research
- Scoliosis diagnosis and treatment
- Osteoarthritis Treatment and Mechanisms
- Spinal Hematomas and Complications
- Circular RNAs in diseases
- Anesthesia and Pain Management
- Musculoskeletal pain and rehabilitation
- MicroRNA in disease regulation
- Bone Tumor Diagnosis and Treatments
- Inflammatory mediators and NSAID effects
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Antifungal resistance and susceptibility
- Extracellular vesicles in disease
- Fungal Infections and Studies
- Pelvic and Acetabular Injuries
- Proteoglycans and glycosaminoglycans research
- Sarcoma Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Management of metastatic bone disease
- Cerebral Palsy and Movement Disorders
- Medical Imaging and Analysis
Central South University
2015-2024
Second Xiangya Hospital of Central South University
2015-2024
Abstract The inflammatory microenvironment in the joints is one of critical issues during osteoarthritis (OA) and also main factor that may aggravate symptoms. Under microenvironment, M1 macrophages are activated produce large numbers proinflammatory mediators, leading to production degradative enzymes, disturbance chondrocyte apoptosis cartilage catabolic processes, finally deterioration OA. In present study, we reveal overexpression osteopontin (OPN), a cytokine, matrix protein involved...
Chondrocyte apoptosis and extracellular matrix (ECM) degeneration have been implicated in the pathogenesis of osteoarthritis (OA). Based on previously reported microarray analysis, HRAS (Harvey rat sarcoma viral oncogene homolog), a member RAS protein family, was chosen as potential regulator OA chondrocyte ECM degradation. expression downregulated tissues, particularly mild-OA tissues. overexpression partially attenuated IL-1β-induced Similar to HRAS, long non-coding RNA LINC00623 knockdown...
Osteosarcoma (OS) is the most common primary bone malignancy with a poor prognosis for all races and both sexes. In this study, we found that miR-381 positive factor OS patients low expression of had longer survival time after surgical intervention, promotes MG-63 cell proliferation invasion ability. Our results also showed strong negative correlation between LRRC4 (brain relative specific gene) in tissues. This demonstrated direct target gene miR-381, suppressing increases sensitivity cells...
Exosomes (exo) are involved in the progression of osteoarthritis (OA). This study aimed to investigate function dysfunctional chondrocyte-derived exo (DC-exo) on OA rats and rat macrophages. Rat-derived chondrocytes were isolated, DCs induced with interleukin (IL)-1β used for isolation. Rats (n = 36) or macrophages treated DC-exo phosphate-buffered saline (PBS). Macrophage polarization autophagy, degradation chondrocyte activity cartilage tissues, examined. RNA sequencing was detect genes...
The optimal treatment for multi-level cervical spondylotic myelopathy (CSM) remains controversial. Posterior approach is most commonly used, but complicated with insufficient decompression and postoperative axial neck pain. anterior effective in neural less surgical trauma. However, the profile of plate or possible construct failure may cause dysphagia after surgery. Recently, discectomy fusion (ACDF) self-anchored cage reported to have a superior result over ACDF plates screws three-level...
Abstract Background To find out if three-dimensional printing (3DP) off-the-shelf (OTS) prosthesis is superior to titanium mesh cages in anterior cervical corpectomy and fusion (ACCF) when treating single-segment degenerative spondylotic myelopathy (DCSM). Methods DCSM patients underwent ACCF from January 2016 2019 a single center were included. Patients divided into the 3DP group (28) TMC (23). The hospital stays, operation time, intraoperative blood loss, cost of hospitalization compared....
Abstract Background For patients with multilevel degenerative cervical myelopathy, laminectomy and posterior fusions (PCF) instrumentation are widely accepted techniques for symptom relief. However, hardware failure is not rare results in neck pain or even permanent neurological lesions. There no in-depth studies of hardware-related complications following PCF instrumentation. Methods The present study was a retrospective, single centre, observational study. Patients who underwent...
Study Design. A retrospective study. Objective. The aim of this study was to evaluate the clinical and radiological outcomes mini-open ALIF (MO-ALIF) with self-anchored stand-alone cages for treatment lumbar disc herniation in comparison transforaminal interbody fusion (TLIF). Summary Background Data. Currently, whether is superior TLIF remains controversial. Methods. This retrospectively reviewed 82 patients who underwent MO-ALIF standalone (n = 42) or 40) between April 2013 October 2014....
Chordoma is a rare, slow‑growing primary malignant neoplasm of the axial skeleton, which arises from remnants notochord. Emerging evidence suggests that microRNAs (miRs) are dysregulated in chordoma tissues and crucially involved pathogenesis. In present study, expression 11 candidate miRs were analyzed miR‑10a miR‑125a found to be significantly downregulated compared with controls. Notably, transcripts, pri‑miR‑125a pri‑miR‑10a was unaltered, suggesting disturbed microRNA may induced by...
Abstract Background Intervertebral disc degeneration and sarcopenia are both age-related diseases without effective treatments. Their comorbidities may worsen the prognosis, further studies on interaction therapy needed. The purpose of study was to investigate prevalence in intervertebral degeneration, compare characteristics with effects interferential current. Methods One hundred twenty patients were included from 2021 2022 a single institute. Medical records, examination results...
The author retrospectively studied twenty-two patients who underwent revision lumbar surgeries using ALLIF with a self-anchored stand-alone polyetheretherketone (PEEK) cage. operation time, blood loss, and perioperative complications were evaluated. Oswestry disability index (ODI) scores visual analog scale (VAS) of leg back pain analyzed preoperatively at each time point postoperative follow-up. Radiological evaluation including fusion, disc height, foraminal subsidence was assessed....
ABSTRACT We present a report of an autosomal-dominant hyper-IgE syndrome patient with vertebral aspergillosis. Early diagnosis and antifungal therapy surgery are crucial for improving the outcome this aggressive condition.
Study Design: This is a case-series. Objective: To evaluate the clinical and radiologic outcomes of posterior vertebral column resection (PVCR) for treatment posttubercular kyphosis in upper thoracic spine cervicothoracic junction (CTJ). Summary Background Data: Surgical management severe or CTJ challenging. A new technique that combines PVCR intraoperative manual traction single procedure, was developed to maximize correction rate minimize risk dural buckling spinal cord injury. However,...
Giant cell tumor (GCT) is an aggressive type of bone consisting multinucleated osteoclast‑like giant cells. Imatinib a selective inhibitor for certain III tyrosine kinase receptor family members with variety beneficial effects. The purpose the present study was to determine therapeutic potential and underlying mechanism imatinib against GCT. In study, viability apoptosis in GCT were analyzed using MTT assay, flow cytometry DAPI staining assay. Caspase‑3 ‑9 activity cells colorimetric assay...