A5101443171- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Gestational Diabetes Research and Management
- Cancer Research and Treatments
- Bariatric Surgery and Outcomes
- Cancer Genomics and Diagnostics
- Cardiac Arrhythmias and Treatments
- Bone and Dental Protein Studies
- Cardiac Valve Diseases and Treatments
- Herpesvirus Infections and Treatments
- Obesity, Physical Activity, Diet
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Caveolin-1 and cellular processes
- Cardiac electrophysiology and arrhythmias
- Exercise and Physiological Responses
- TGF-β signaling in diseases
- Diabetes Management and Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Obesity and Health Practices
- Vitamin D Research Studies
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
- Dietetics, Nutrition, and Education
Wellcome/MRC Institute of Metabolic Science
2023-2025
University of Cambridge
2021-2025
University of Kansas
2024
University of Kansas Medical Center
2024
Guy's and St Thomas' NHS Foundation Trust
2023-2024
Wellcome Trust
1986-2023
MRC Epidemiology Unit
2021-2023
Emory University
2022
University of Kentucky
2018-2019
The Ohio State University Wexner Medical Center
2017
Abstract Aims/hypothesis Precision medicine approaches to gestational diabetes mellitus (GDM) have categorised patients according disease pathophysiology (insulin resistance, insulin insufficiency or both), and demonstrated associations with clinical outcomes. We aimed assess whether using enhanced processing determine indices of secretion sensitivity is analytically robust, reproducible in a different population, useful diagnostically prognostically practice. Methods A total 1308 pregnant...
We aimed to assess whether energy restriction, weight loss, or maternal glycemia in late pregnancy were associated with breastfeeding outcomes. This is a secondary analysis of the Dietary Intervention Gestational Diabetes (DiGest) randomized controlled trial, which included 425 participants gestational diabetes who randomly assigned receive standard-energy (2,000 kcal/day) reduced-energy (1,200 diet box from 29 weeks until delivery, masked continuous glucose monitoring. Breastfeeding...
Purpose of review The prevalence women entering pregnancy with overweight or obesity is increasing which raises concerns for adverse outcomes mothers and their infants. Evidence suggests that appropriate gestational weight gain important, irrespective maternal BMI. aim this present article to the evidence on management during evaluate current interventions. Recent findings There currently no standardized definition ‘excessive’ a unified approach manage weight, despite rising globally....
Pregnant women with previous bariatric surgery are at increased risk of gestational diabetes mellitus (GDM) but many cannot safely tolerate the oral glucose tolerance test (OGTT). Consensus recommendations advise self-monitoring blood (SMBG) for GDM diagnosis, diagnostic thresholds unexplored in this population. to assess incidence SMBG-defined (fasting, 1-hr postprandial thresholds: 90, 140 mg/dl (5.3, 7.8 mmol/l)) after surgery, compared OGTT-defined factors no history surgery. patients a...
We present an enhancer AAV toolbox for accessing and perturbing striatal cell types circuits. Best-in-class vectors were curated major neuron populations including medium spiny neurons (MSNs), direct indirect pathway MSNs, as well Sst-Chodl, Pvalb-Pthlh, cholinergic interneurons. Specificity was evaluated by multiple modes of molecular validation, three different routes virus delivery, with diverse transgene cargos. Importantly, we provide detailed information necessary to achieve reliable...
Sixty immunocompetent patients with herpes zoster of various dermatomes were treated 5 times a day for days either acyclovir at dose 400 mg or placebo. Acyclovir was shown to reduce significantly the time full crusting (P= 0.02). There also trends in favour first dry vesicle and without macules papules, but these not statistically significant. no differences between groups occurrence adverse events postherpetic neuralgia.
Patients with 6 or more recurrences per year of herpes labialis were entered into a randomized, double-blind, placebo-controlled, crossover study. During the trial, they applied acyclovir cream for 16 weeks and placebo to all previously affected areas 4 times day, subsequently observed further no treatment. Results from 23 evaluable cases showed that although did occur whilst on treatment, patients suffered significantly fewer days disease attacks cold sores when compared placebo.
Fifty patients presenting with first episode genital herpes were randomly allocated to seven day treatment either oral acyclovir plus 5% cream or matching placebo cream. Combined and topical was associated a shorter duration of itching in women alone (p = 0.04) but gave no clinical relief other symptoms, the time healing lesions, subsequent recurrence rate. Concomitant confers advantages on who receive acyclovir.
Introduction: Precision medicine approaches to gestational diabetes mellitus (GDM) have categorised patients according disease pathophysiology (insulin resistance, insulin insufficiency, both) and demonstrated associations with clinical outcomes. We assessed if this approach is analytically robust, reproducible in a different population useful diagnostically, prognostically or therapeutically practice. Methods: 1308 pregnant women >1 risk factor having an oral glucose tolerance test...
Abstract Background The dietary restriction of fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs), called the low‐FODMAP diet (LFD), is frequently used to manage irritable bowel syndrome (IBS). This service evaluation aimed assess long‐term effectiveness LFD in managing IBS symptoms whether symptom response adherence were associated. Methods observational collected data via questionnaires during clinical dietetic appointments for management. Symptom severity...
Intramyocellular (IMCL), extramyocellular lipid (EMCL), and vitamin D deficiency are associated with muscle metabolic dysfunction. This study compared the change in [IMCL]:[EMCL] following combined treatment of aerobic training (DAT) (D), (AT), control (CTL). Male female subjects aged 60-80 years a BMI ranging from 18.5-34.9 status ≤32 ng/mL (25(OH)D) were recruited to randomized, prospective clinical trial double-blinded for supplement 2 × factorial design. Cholecalciferol (Vitamin D3)...
Incretin hormones glucagon-like peptide 1 (GLP-1) and gastric inhibitory (GIP) cause increased insulin secretion in non-pregnant adults, but their role pregnancy, where there are additional metabolically-active from the placenta, is less clear. The aim of present study was to assess if fasting post-load incretin concentrations were predictive pregnancy glucose concentrations.Pregnant women (n = 394) with one or more risk factors for gestational diabetes recruited at 28 weeks a 75 g oral...
Childhood obesity is an area of intense concern internationally and influenced by events during antenatal postnatal life. Although pregnancy complications, such as gestational diabetes large-for-gestational-age birthweight have been associated with increased risk in offspring, very few successful interventions identified. We describe a study protocol to identify if reduced calorie diet can reduce adiposity children 3 years age. The dietary intervention (DiGest) randomised, controlled trial...
Background: Continuous glucose monitoring (CGM) is increasingly used in gestational diabetes but the optimal metrics and targets this population are undefined. We assessed if CGM were associated with pregnancy outcomes diabetes. Methods: 432 women (BMI >25 kg/m2) received a dietary intervention (DiGest trial; ISRCTN; 37866), masked (Dexcom G6) at 29 (n=332) 36wks (n=225) respectively. logistic regression, adjusted for trial arm, to assess associations between standardized outcomes,...
Background: Reduced-energy diets improve clinical outcomes in type 2 diabetes but are untested gestational diabetes. Methods: In a randomized, controlled, double-blind, whole-diet replacement trial (ISRCTN; 37866), women with and BMI <u>></u>25 kg/m2 were assigned (1:1) to receive standard-energy (2000 kcal/day) (control) or reduced-energy diet (1200 (intervention) until delivery, provided as weekly dietboxes containing 40% carbohydrate, 35% fat 25%...
Dietary fiber improves glycemic control in type 2 diabetes, but its therapeutic role pregnancy diabetes is unclear. We assessed the effect of dietary on glycemia women with pregnancy. Methods: searched three databases (Cochrane Library, MEDLINE, Web Science) to identify RCTs exploring fiber, high diets or supplementation fasting blood glucose (FBG), postprandial (PBG), and requirement for insulin therapy pregnant any diabetes. Data was pooled each outcome, we calculated Hedges’ g from...