A5063035129- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Stroke Rehabilitation and Recovery
- Clinical practice guidelines implementation
- Health disparities and outcomes
- Atrial Fibrillation Management and Outcomes
- Peripheral Artery Disease Management
- Renal and Vascular Pathologies
- COVID-19 and healthcare impacts
- Nutritional Studies and Diet
- Antiplatelet Therapy and Cardiovascular Diseases
- Long-Term Effects of COVID-19
- Estrogen and related hormone effects
- Ultrasound in Clinical Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Moyamoya disease diagnosis and treatment
- Transplantation: Methods and Outcomes
- Venous Thromboembolism Diagnosis and Management
- interferon and immune responses
- Immune Response and Inflammation
- Vasculitis and related conditions
Hospital Universitario Virgen del Rocío
2014-2024
Instituto de Biomedicina de Sevilla
2019-2024
Universidad de Sevilla
2020-2024
National University of Comahue
2024
CollegeAmerica
2023
Vall d'Hebron Institut de Recerca
2016-2020
Hospital Universitario Fundación Jiménez Díaz
2020
University of Göttingen
2016
Universidad Autónoma de Nuevo León
2015
Max Planck Institute for Infection Biology
2014
Background and Purpose: Emergency measures to treat patients with coronavirus disease 2019 (COVID-19) contain the outbreak is main priority in each of our hospitals; however, these are likely result collateral damage among other acute diseases. Here, we investigate whether COVID-19 pandemic affects stroke care through interruptions chain survival. Methods: A descriptive analysis activity before after given for a network southern Europe. To quantify impact pandemic, number code activations,...
Background and Purpose Carotid endarterectomy reduces stroke risk in patients with >70% symptomatic stenosis. We present our results of percutaneous transluminal angioplasty (PTA) as an alternative treatment. Methods Ninety-eight stenosis the internal carotid artery were considered for PTA. Details procedure, complications, 4-year follow-up registered. Results Eighty-five PTAs performed a period. Transient cardiovascular effects frequent: hypotension (54.1%), bradycardia (67.1%), asystole...
Licofelone, a dual anti-inflammatory drug that inhibits 5-lipoxygenase (LOX) and cyclooxygenase (COX) enzymes, may have better cardiovascular profile cycloxygenase-2 inhibitors due to cycloxygenase-1 blockade-mediated antithrombotic effect gastrointestinal tolerability. We examined the of licofelone on atherosclerotic lesions as well in isolated neutrophils from whole blood rabbits compared with selective inhibitor COX-2, rofecoxib. also assessed rabbit platelet-rich plasma. For this...
Trichosporon asahii is considered an opportunistic pathogen responsible for severe infections, mainly in immunocompromised patients. The aims of this study were to investigate the prevalent genotypes among 39 clinical isolates microorganism by sequencing IGS1 region and determine vitro production DNAse, hemolysin, aspartyl proteinase, phospholipase esterase, as well susceptibilities amphotericin B, anidulafungin, micafungin, caspofungin, voriconazole, posaconazole, fluconazole 5-flucytosine....
Restenosis after carotid angioplasty (with or without stent) is associated with increased rate of stroke and death. Our aim was to determine risk predictive factors related restenosis post its association recurrent cerebrovascular events.All consecutive patients stenosis treated (n=1060) in a single University Hospital were included (from 2002 2013). Follow-up done prospectively evaluating restenosis, ipsilateral stroke, defined as narrowing ≥70% previously vessel evaluated by...
Bone marrow mononuclear cell (BM-MNC) intra-arterial transplantation improves recovery in experimental models of ischemic stroke through secretion cytokines and growth factors (GFs), enhancing neoangiogenesis, neuroplasticity. In this study, we tested whether BM-MNC patients induces changes serum levels GFs. A phase I/II trial was conducted middle cerebral artery (MCA) with autologous between 5 9 days after stroke. Follow-up done for up to 6 months. Eight cases nine controls were included,...
Acute aortic occlusion is an infrequent disease but with significant mortality. The new pandemic of the SARS-CoV-2 coronavirus (COVID-19) represents a great challenge for health systems. This contagious generating high infection and mortality rates in several countries. It speculated that inflammatory process accompanying triggered by massive macrophage activation associated development coagulopathy. We present three cases COVID-19 patients, treated our hospital during period 2 weeks, who...
<h3>BACKGROUND AND PURPOSE:</h3> The natural history of the carotid NO is poorly characterized, and management patients remains controversial. We report results complications associated with CAS follow-up. <h3>MATERIALS METHODS:</h3> Between March 2000 2009, 116 836 procedures were performed in (13.9%). A total 99 men (85.3%) 17 women (14.7%) a mean age 65.8 years included. Presenting symptoms TIA 44 (37.9%) minor stroke or noninvalidating 61 (52.6%). One hundred five (90.5%) symptomatic....
Bypass grafting is considered the treatment of choice for occlusions supraaortic vessels. Percutaneous transluminal angioplasty (PTA) a well-established patients with subclavian stenosis, but its efficacy in total or innominate so far not well established. Since 1995, we have carried out 9 PTA revascularizations symptomatic atherosclerotic occlusion The technical success rate was 100%, without any major (death stroke) minor complications. In follow-up period (mean 37.4 months), 1 patient had...
Angioplasty and stenting of the atheromatous internal carotid artery (ICA), besides in patients with a high surgical risk, may be indicated specific cases such as contralateral occlusion, acute stroke clinical signs, or atherosclerotic pseudo-occlusion (APO). APO ICA is an underrecognized condition due to diagnostic difficulties both noninvasive methods even angiography. Once recognized, there usually opportunity for successful revascularization endarterectomy. However, natural history...
PurposeTo determine the incidence of vulnerable plaques characterized by virtual histology intravascular ultrasound (VH IVUS) in patients with severe internal carotid artery (ICA) stenosis and its relationship to timing protected stenting (CAS). MethodsThe study included 141 (119 men; mean age 66.9 ± 9 years) ICA undergoing CAS cerebral protection. Patients were classified 3 groups: 39 symptomatic early (<14 days from clinical symptoms); 58 delayed (range 15–180 days), 44 asymptomatic CAS....
We aimed to assess baseline inter-hemispheric perfusion differences, before carotid artery stenting (CAS), of severe internal (ICA) stenosis, and evaluate changes over time after CAS by means weighted imaging (PWI).Dynamic susceptibility contrast PWI was performed in 33 patients with ICA stenosis 1 day CAS, repeated 23 30 days CAS. Cerebral blood volume, cerebral flow, arrival (T0), mean transit time, peak (TTP) relative values comparing symptomatic asymptomatic hemispheres were obtained....
The management of clopidogrel in hyper-responders has not been well described. We report the treatment and dose adjustment individualization with oral solution (COS) hyper-responder patients an unruptured intracranial aneurysm treated a stent.A prospective study (2015-2018) receiving prior to endovascular was performed. Platelet reactivity after therapy evaluated VerifyNow PRU test. Initial values ≤80 (P2Y12 units) were classified as hyper-response according evidence. Patients for 7-10 days...
In recent decades, mortality rates for cerebrovascular diseases (CVD) have declined significantly in many countries. This study analyses changes CVD Spain (1980-2011) to determine if previously observed trends remain. Data on and the population data needed analysis were provided by Spain's National Statistics Institute. We calculated age-specific rate, age-standardised overall mortality, age-truncated (35-64 years) using direct method standard European structure. Joinpoint was used estimate...
<i>Background:</i> Despite advances in the surgical treatment of patients with severe internal carotid stenosis (ICA), there are selective groups who, due to several reasons, not good candidates for surgery. Patients contralateral occlusion one these subgroups. Thereby, other therapeutic alternatives, such as angioplasty may be value. So far, has been little published data about (CA) or stenting (CAS) those patients. The objective this study was evaluate efficacy and safety...