A5075031699- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Mesenchymal stem cell research
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Comparative International Legal Studies
- Administrative Law and Governance
- Pneumonia and Respiratory Infections
- Cancer Genomics and Diagnostics
- Finance, Taxation, and Governance
- Nutritional Studies and Diet
- Intracerebral and Subarachnoid Hemorrhage Research
- Extracellular vesicles in disease
- Cardiac Imaging and Diagnostics
- Oropharyngeal Anatomy and Pathologies
- Ion Transport and Channel Regulation
- Statistical Methods in Clinical Trials
- Biochemical Analysis and Sensing Techniques
- Dye analysis and toxicity
- COVID-19 diagnosis using AI
- Neurological Disease Mechanisms and Treatments
- Pharmacogenetics and Drug Metabolism
Instituto de Biomedicina de Sevilla
2016-2023
Hospital Universitario Virgen del Rocío
2010-2020
Universidad de Sevilla
2019-2020
Hospital Universitario Virgen Macarena
2017-2020
Health First
2019
Vall d'Hebron Institut de Recerca
2016
Restenosis after carotid angioplasty (with or without stent) is associated with increased rate of stroke and death. Our aim was to determine risk predictive factors related restenosis post its association recurrent cerebrovascular events.All consecutive patients stenosis treated (n=1060) in a single University Hospital were included (from 2002 2013). Follow-up done prospectively evaluating restenosis, ipsilateral stroke, defined as narrowing ≥70% previously vessel evaluated by...
<h3>Background</h3> Mortality derived from ST-elevation myocardial infarction (STEMI) has decreased due to primary percutaneous coronary intervention (PCI). Paradoxically, the incidence of heart failure secondary left ventricular remodelling (LVR) is on rise survival reperfusion strategies. The aim this study was assess prognostic value for LVR biomarkers involved in several pathophysiological mechanisms activated during STEMI treated with PCI. <h3>Methods</h3> 112 patients undergoing PCI...
Circulating cell-free DNA (cfDNA) has been described as a prognostic marker for several diseases. Its value short-term outcome in stroke patients treated with intravenous thrombolysis remains unexplored. cfDNA was measured on admission 54 tissue plasminogen activator (tPA)-treated and 15 healthy controls using real-time quantitative polymerase chain reaction assay. Neurological assessed at 48 h. Predictors of neurological improvement were evaluated by logistic regression analysis, the...
Abstract To confirm the diagnostic accuracy of candidate biomarkers in stroke‐associated pneumonia (SAP), we prospectively enrolled ischemic stroke patients with NIHSS ≥ 10 on admission from March‐2016 to August‐2017. Blood samples were collected at baseline, 24 and 48 h after onset. Biomarkers (MR‐proADM, suPAR, SAA) determined by immunoassays. Regarding biomarkers, MR‐proADM ( P = 0.04) both suPAR SAA 0.036 0.057) associated pneumonia. The combination > 25.15 mg/dL suPAR> 3.14 ng/mL...
Abstract Acenocoumarol is an oral anticoagulant with significant interindividual dose variations. Variants in CYP2C9 and VKORC1 have been associated acenocoumarol maintenance dose. We analysed whether any of the 49 polymorphisms previously a Genome-Wide Association study (GWAs) Dutch population are stroke recurrence, intracranial haemorrhage (ICH) Spanish population. performed GWAs using Human Core Exome-chip (Illumina) 78 patients treated for secondary prevention enrolled as part...
This study was supported by a Spanish grant from the Instituto de Salud Carlos III (ISCIII-FIS IP14/00971,2014-2017). The ITRIBIS project (Improving Translational Research Potential at Institute of Biomedicine Seville) has registration number REGPOT-2013-1. Cooperative Cerebrovascular Disease Network (INVICTUS+)(RD16/0019/0015). Fernando Mancha is Rio Hortega contract. Francisco Moniche PI PI15/01197 and PI18/01414 grants. This partially funded Abbott (Chicago, IL, USA) Grifols (Barcelona,...
To determine the utility of TNF-α receptor (TNFR1) as a biomarker for presence aneurysms in patients with acute subarachnoid hemorrhage (SAH).This is prospective study spontaneous SAH. Arterial blood from catheter near aneurysm and peripheral venous samples are collected. TNFR1 levels were analyzed without aneurysm.80 included, 58 analyzed. 41 (70.7%) had an aneurysm. Venous >1658 pg/ml 46.3% sensitivity 94.1% specificity presence. was also independent predictor its (odds ratio = 12.03...
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Previous studies have shown the potential of microRNAs (miRNA) in pathological process stroke and functional recovery. Bone marrow mononuclear cell (BM-MNC) transplantation improves recovery experimental models ischemic that might be related with miRNA modifications. However, its effect on circulating has not been described patients stroke. We aimed to evaluate levels miRNAs after autologous BM-MNC investigate pattern miRNA-133b miRNA-34a expression included a multicenter randomized...
Background and Aims: The benefits of Mediterranean Diet (MeDiet) in prevention cardiovascular diseases (CVD) general ischemic stroke (IS) have been extensively studied reported. We hypothesize that the consumption nutrients typical MeDiet would also reduce rate silent brain infarcts (SBI) among AF patients. Methods Results: Patients with a history who scored 0 to 1 CHADS2 score, ⩾50 years absence neurological symptoms were selected from Seville urban area using Andalusian electronic...