A5074346719- Ovarian function and disorders
- Child and Adolescent Health
- Reproductive Biology and Fertility
- Research in Social Sciences
- Social Issues and Policies
- Health disparities and outcomes
- Ovarian cancer diagnosis and treatment
- Adolescent and Pediatric Healthcare
- Hypothalamic control of reproductive hormones
- Fluid Dynamics and Turbulent Flows
- Growth Hormone and Insulin-like Growth Factors
- Computational Fluid Dynamics and Aerodynamics
- Chronic Disease Management Strategies
- Sexual Differentiation and Disorders
- Primary Care and Health Outcomes
- Global Health Workforce Issues
- Food Security and Health in Diverse Populations
- Gas Dynamics and Kinetic Theory
- Sperm and Testicular Function
- Human Health and Disease
- Hormonal and reproductive studies
- demographic modeling and climate adaptation
- Poverty, Education, and Child Welfare
- Birth, Development, and Health
- Pharmacological Effects and Toxicity Studies
University of Otago
2022
Massachusetts General Hospital
2005-2020
Harvard University
2000-2013
The University of Melbourne
1999-2007
Reykjavík University
2007
National University Hospital of Iceland
2007
Weatherford College
2005-2007
Royal Children's Hospital
1999-2006
Conexant (United States)
2003
Brigham and Women's Hospital
2000
Polycystic ovaries were defined with ultrasound imaging in a series of 173 women who presented to gynaecological endocrine clinic anovulation or hirsutism. found 26% amenorrhoea, 87% oligomenorrhoea, and 92% idiopathic hirsutism--that is, hirsutism but regular menstrual cycles. Fewer than half the anovulatory patients polycystic hirsute, 93% cases there was at least one abnormality support diagnosis ovaries--that raised serum concentrations luteinising hormone, hormone: follicle stimulating...
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder of reproductive age women characterized in its broadest definition by the presence oligoamenorrhea and hyperandrogenism absence other disorders. Defects gonadotropin secretion, including an elevated LH level, to FSH ratio, increased frequency amplitude pulsations have been described, but prevalence these defects large, unbiased population PCOS patients has not determined. Sixty-one with defined oligomenorrhea 24 normal early...
The empirical observation is well documented that currency exposure can add risk to an unhedged international equity portfolio. Extending work, this article uses three manipulations of the standard portfolio equation show (1) why acts as implicit leverage in a and therefore increase risk, even under assumption zero correlation; (2) how, additional assumption, reduces Pythagorean that, by using result, simple proof always riskier than hedged one; (3) how be rearranged give "correlation...
SCN1B, the gene encoding sodium channel beta 1 subunit, was first identified for generalized epilepsy with febrile seizures plus (GEFS+). Only three families have been published SCN1B mutations. Here, we present four new mutations and characterize associated phenotypes. Analysis of performed on 402 individuals various syndromes. Four probands missense were identified. Detailed electroclinical phenotyping all available affected family members including quantitative MR imaging in those...
The Rotterdam criteria for polycystic ovary syndrome (PCOS) defines discrete subgroups whose phenotypes are not yet clear.The phenotypic characteristics of women in the PCOS defined by were compared.The study was observational.Subjects studied an outpatient setting Boston and Reykjavik.Four subjects with 1) irregular menses (IM), hyperandrogenism (HA), morphology (PCOM, n = 298); 2) IM/HA (n 7); 3) HA/PCOM 77); 4) IM/PCOM 36) a group controls 64), aged 18-45 yr, examined.Subjects underwent...
To determine the relevance of polycystic ovarian morphology (PCOM) to pathophysiology syndrome (PCOS), biochemical features associated with PCOS were examined in 68 women an established history regular ovulatory cycles and no clinical evidence hyperandrogenism. Ovarian was objectively assessed by pelvic ultrasound. LH, FSH, estradiol (E2), testosterone (T), androstenedione (Δ4A), SHBG, dehydroepiandrosterone sulfate (DHEAS) measured at baseline early follicular phase (EFP) all subjects. E2,...
High resolution ultrasonography was used to establish the presence of polycystic ovaries (PCO) in 50 women with symptoms ovary syndrome and 17 congenital adrenal hyperplasia. One hundred thirty-seven post-menarcheal, premenopausal female members families these patients were scanned assess heredity condition. Familial PCO found 56 61 pedigrees (92%) which sufficient available for study. The frequency relatives hyperplasia no different from that main group. Twenty-four out thirty-six (67%)...
Journal Article Comparison of exogenous gonadotropins and pulsatile gonadotropin-releasing hormone for induction ovulation in hypogonadotropic amenorrhea Get access K A Martin, Martin 1Department Medicine, Massachusetts General Hospital, Boston 02114. Search other works by this author on: Oxford Academic Google Scholar J E Hall, Hall M Adams, Adams W F Crowley, Jr The Clinical Endocrinology & Metabolism, Volume 77, Issue 1, 1 July 1993, Pages 125–129,...
The phenotype of women with polycystic ovary syndrome (PCOS) is variable, depending on the ethnic background.The phenotypes PCOS in Iceland and Boston were compared.The study was observational a parallel design.Subjects studied an outpatient setting.Women, aged 18-45 yr, defined by hyperandrogenism fewer than nine menses per year, examined (n = 105) 262).PCOS subjects underwent physical exam, fasting blood samples for androgens, gonadotropins, metabolic parameters, transvaginal...
Concept: Ovaries meeting criteria for polycystic ovary morphology during peak reproductive years may no longer meet the with age. Objective: Ovarian volume and follicle number decrease age in women syndrome (PCOS), permitting age-dependent PCOM. Design Setting: We conducted longitudinal (7–15 year interval) cross-sectional studies to examine ovarian over time at an outpatient clinic pathology laboratory a tertiary care hospital. Patients: Subjects included those PCOS defined by National...
Abstract Objective To evaluate development of components polycystic ovary syndrome (PCOS) and PCOS in women with epilepsy initiating valproate or lamotrigine therapy. Methods Female individuals regular menstrual cycles were eligible for this prospective study. Participants randomized to 12 months (n = 225) 222) Serum androgen levels measured every 3 months. Urinary pregnanediol glucuronide weekly two 3‐month periods. The primary end point was (ie, hyperandrogenism ovulatory dysfunction). A...
Ovulation was successfully induced with luteinising hormone releasing in 28 women hypothalamic amenorrhoea who had failed to respond treatment clomiphene. Luteinising administered a pulsatile manner miniaturised automatic infusion systems. The rate of ovarian follicular maturation, as monitored by serial pelvic ultrasonography, similar that observed spontaneous cycles. Endocrine assessment measurement gonadotrophin, oestradiol, and progesterone concentrations showed be within the normal...
Summary. Asymptomatic volunteer women with a regular pattern of uterine bleeding and using the progestogen‐only oral contraceptive pill were compared control who not exposed to hormones. Pelvic ultrasound scanning at end next episode after recruitment demonstrated functional cysts maximum diameters ranging between 30 58 mm in eight 21 users, four whom also had palpable ovaries, three regressed during cycle. Of 13 normal ovaries initially, developed new cyst which two associated pain. 12...
Previous studies of normal human ovaries suggest that inhibins, activins, and follistatin (FS) are produced in a stage-specific pattern indicative intraovarian, autocrine/paracrine roles regulating follicle development. However, these relied largely on surgical specimens thus include little information about the menstrual cycle stage or dominant status at time follicles were obtained. The purpose this study was to 1) determine intrafollicular hormone biosynthesis across antral development...
Journal Article Signs and Regimes: Rereading Feminist Work on Welfare States Get access JULIA ADAMS, ADAMS Search for other works by this author on: Oxford Academic Google Scholar TASLEEM PADAMSEE Social Politics: International Studies in Gender, State & Society, Volume 8, Issue 1, Spring 2001, Pages 1–23, https://doi.org/10.1093/sp/8.1.1 Published: 01 March 2001
Context: Previous studies suggest that inhibin subunit expression is decreased in granulosa cells of women with polycystic ovary syndrome (PCOS). Objective: The objective this study was to test the hypothesis A and B protein concentrations are also PCOS follicles. Design: design a parallel study. Setting: performed at an vitro fertilization suite. Participants: We studied regular cycles (n = 36) 8). Interventions: Follicular fluid aspirated from follicles 14 follicles) various times during...
Premature ovarian failure is classically defined as menopause occurring before age 40 and associated with elevated serum FSH levels. If levels indicate lack of feedback depletion primordial follicles, women prematurely should have infertility. However, there are many reports pregnancies in affected during estrogen therapy leading to the hypothesis that may a salutary effect on folliculogenesis conception. This randomized, controlled trial was designed investigate whether replacement offered...
The midcycle gonadotropin surge is a critical event in normal reproductive cycles and requires functional integration of the hypothalamus, pituitary, ovary. To determine whether change GnRH frequency occurs coincident with onset or termination women, 20 studies were performed at sampling interval every 5 min for up to 36 h. pulsatile secretion was assessed by use two surrogate markers its secretion, LH free alpha-subunit (FAS). timing prospectively determined serial ultrasound previous cycle...
Menstrual irregularity after menarche has been attributed to immature estrogen positive feedback activity (E+FB) but data are conflicting. To determine the hypothalamic–pituitary–ovarian contributions menstrual in adolescents. Twenty-three healthy girls [aged 12.8 17.6 years; 0.4 3.5 years postmenarche; body mass index (BMI) percentile, 41.0 99.3] underwent serial hormone measurements and pelvic ultrasounds during two consecutive cycles. Hormones follicle growth were compared with 65 adult...
Previous studies demonstrate that inhibin A and B are differentially secreted across the menstrual cycle. To test hypothesis responses of to partial gonadotropin withdrawal influenced by stage follicular development, a maximally suppressive dose Nal-Glu GnRH antagonist (150 μg/kg) was administered normal cycling women during midfollicular (MFP; n = 8), late (LFP; 6), midluteal phase (MLP; 5) assess ovarian responsiveness over broad range developmental stages. Administration resulted in...