A5007427257- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- S100 Proteins and Annexins
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- PARP inhibition in cancer therapy
- Mitochondrial Function and Pathology
- Immune Response and Inflammation
- Cancer Research and Treatments
- Genomics and Chromatin Dynamics
- Amyloidosis: Diagnosis, Treatment, Outcomes
- RNA Research and Splicing
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Trace Elements in Health
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- interferon and immune responses
- Long-Term Effects of COVID-19
- Circular RNAs in diseases
- Extracellular vesicles in disease
University of Münster
2020-2022
The Ohio State University Wexner Medical Center
2020
University Hospital Münster
2020
The Ohio State University
2016-2018
Ohio University
2018
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2018
Mario Negri Institute for Pharmacological Research
2014-2018
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2018
Columbus Oncology and Hematology Associates
2017
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2014
The knowledge of the mechanism underlying cardiac damage in immunoglobulin light chain (LC) amyloidosis (AL) is essential to develop novel therapies and improve patients' outcome. Although an active role reactive oxygen species (ROS) LC-induced cardiotoxicity has already been envisaged, actual mechanisms behind their generation remain elusive. This study was aimed at further dissecting action ROS generated by cardiotoxic LC vivo investigating whether transition metal ions are involved this...
Abstract Background Tumor-associated microglia and macrophages (TAMs) myeloid-derived suppressor cells (MDSCs) are potent immunosuppressors in the glioma tumor microenvironment (TME). Their infiltration is associated with grade, progression, therapy resistance. Specific tools for image-guided analysis of spatiotemporal changes immunosuppressive myeloid compartments missing. We aimed (i) to evaluate role fluorodeoxyglucose (18F)DPA-714* (translocator protein [TSPO]) PET-MRI assessment TME...
There is growing concern about the presence of nanoparticles (NPs) in titanium dioxide (TiO2) as food additive (E171). To realistically estimate number and amount TiO2 NPs ingested with food, we applied a transmission electron microscopy method combined inductively coupled plasma optical emission spectrometry. Different percentages (6–18%) were detected E171 from various suppliers. In eight chewing gums analyzed prototypes, absent one sample ranged 0.01–0.66 mg/gum, corresponding to 7–568...
Creutzfeldt–Jakob disease (CJD) is a neurodegenerative disorder caused by prion protein (PrP) misfolding, clinically recognized cognitive and motor deficits, electroencephalographic abnormalities, seizures. Its neurophysiological bases are not known. To assess the potential involvement of NMDA receptor (NMDAR) dysfunction, we analyzed NMDA-dependent synaptic plasticity in hippocampal slices from Tg(CJD) mice, which model genetic form CJD. Because PrP depletion may result functional...
Rationale: The heterogeneous nature of gliomas makes the development and application novel treatments challenging. In particular, infiltrating myeloid cells play a role in tumor progression therapy resistance. Hence, detailed understanding dynamic interplay immune vivo is necessary. To investigate complex interaction between therapy-induced changes component microenvironment, we used combination [18F]FET (amino acid metabolism) [18F]DPA-714 (TSPO, GAMMs, cells, astrocytes, endothelial cells)...
Immune cells have been implicated in influencing stroke outcomes depending on their temporal dynamics, number, and spatial distribution after ischemia.Depending activation status, immune can detrimental beneficial properties tissue outcome stroke, highlighting the need to modulate inflammation towards restorative responses.Novel dietary therapies may promote modulation of pro-and anti-inflammatory cell functions.Among interventions inspired by Mediterranean diet, hydroxytyrosol (HT), main...
// Dario Palmieri 1, 2 , Mario Scarpa Anna Tessari 1 Rexhep Uka Foued Amari Cindy Lee Timothy Richmond Claudia Foray Tyler Sheetz Ashley Braddom Christin E. Burd Jeffrey D. Parvin Thomas Ludwig Carlo M. Croce Vincenzo Coppola Department of Molecular Virology, Immunology and Medical Genetics, College Medicine, 43210 Columbus, OH, USA Solid Tumor Biology Program, Comprehensive Cancer Center, The Ohio State University, Correspondence to: Coppola, e-mail: Vincenzo.coppola@osumc.edu Keywords:...
<b>Background:</b> Glioma-associated microglia/macrophages (GAMM) are key players in creating an immunosuppressive microenvironment. They can be efficiently targeted by inhibiting the colony stimulating factor-1 receptor (CSF-1R). We employed non-invasive PET/CT-MRI using <sup>18</sup>F-FET (amino-acid metabolism) and <sup>18</sup>F-DPA-714 (translocator protein - TSPO) to (i) understand role of GAMM glioma initiation, (ii) monitor in-vivo therapy-induced depletion, (iii) observe...
Microglia-induced neuroinflammation after stroke contributes to the exacerbation of post-ischemic damage but also supports neurorestorative events. Longitudinal molecular imaging microglia-targeted therapies will support assessment target engagement, therapy efficacy, and deciphering mode action. We investigated effects chronic colony stimulating factor-1 receptor (CSF-1R) inhibitor-mediated microglia depletion on translocator protein (TSPO)-dependent cerebrovascular parameters using...
The simultaneous presence of cardiac and renal diseases is a pathological condition that leads to increased morbidity mortality. Several lines evidence have suggested lipid dysmetabolism mitochondrial dysfunction are pathways involved in the processes affecting heart kidney. In salt-loaded spontaneously hypertensive stroke-prone rat (SHRSP), model hypertrophy nephropathy shows alterations myocardium, we evaluated cardiorenal effects fenofibrate, peroxisome proliferator-activated receptor...
Studies on colony-stimulating factor 1 receptor (CSF-1R) inhibition-induced microglia depletion indicated that inhibitor withdrawal allowed the renewal of compartment via repopulation and resolved inflammatory imbalance. Therefore, we investigated for first time (to our knowledge) effects inflammation functional outcomes in an ischemic mouse model using translocator protein (TSPO)-PET/CT MR imaging, ex vivo characterization, behavioral tests. Methods: Eight C57BL/6 mice per group underwent a...
IWS1 is an RNA-polymerase II (RNAPII)-associated transcription elongation factor whose biological functions are poorly characterized. To shed some light on the function of this protein at organismal level, we performed a systematic tissue analysis its expression and generated Iws1-deficient mice. A thorough immunohistochemical characterization shows that present in nucleus all cells most examined tissues, with few notable exceptions. We also report ablation Iws1 consistently causes lethality...
Prostate cancer (PCa) is the most frequently diagnosed in men and second common cause of cancer-related deaths United States. Androgen deprivation therapy (ADT) only temporarily effective for advanced-stage PCa, as disease inevitably progresses to castration-resistant prostate (CRPC). The protein nucleolin (NCL) overexpressed several types human tumors where it also mislocalized cell surface. We previously reported identification a single-chain fragment variable (scFv) immuno-agent that able...
In vivo positron emission tomography (PET) and magnetic resonance imaging (MRI) support non-invasive assessment of the spatiotemporal expression proteins interest functional/structural changes. Our work promotes use a volumetric analysis on multimodal datasets to assess spatio-temporal dynamics interaction two biomarkers, with special focus neuroinflammation-related translocator protein (TSPO) matrix metalloproteinases (MMPs), in acute chronic post-ischemic phase. To improve our understating...
Abnormalities in protein folding are involved many localized and systemic diseases, all of which characterized by insoluble amyloid formation deposition. In immunoglobulin light chain (LC) amyloidosis, the most frequent form involvement heart dictates prognosis elucidation mechanism targeting toxicity is essential for designing testing new effective treatments. To this end, availability an appropriate animal model crucial. We recently described use C. elegans as innovative experimental...
You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology II1 Apr 2017MP83-15 A NOVEL THERAPY FOR CASTRATION-RESISTANT PROSTATE CANCER THROUGH INHIBITION OF ONCOGENIC MICRORNAS Tyler Sheetz, Dario Palmieri, Vincenzo Coppola, Anna Tessari, Joseph Mills, Ashley Braddom, Erika Reese, Claudia Foray, Kareesma Parbhoo, and Carlo M. Croce SheetzTyler Sheetz More articles by this author , PalmieriDario Palmieri CoppolaVincenzo Coppola TessariAnna Tessari MillsJoseph Mills...