Gene therapy may be a promising approach for treatment of brain ischemia, although the efficiency postischemic gene is not established. Our goal in this study was to examine effects transfer interleukin-10 (IL-10), an antiinflammatory cytokine, after induction ischemia.Brain ischemia produced by either photochemical occlusion distal middle cerebral artery focal or bilateral carotid global spontaneously hypertensive rats. Adenoviral vectors encoding human IL-10 (AdIL10) beta-galactosidase...

Purpose This study compared the three-dimensional (3D) morphology of mandible, temporomandibular joint (TMJ), and condylar movement in skeletal Class II III patients investigated correlations between each pattern.

Monocyte chemoattractant protein-1 (MCP-1) is expressed in the ischemic cortex after focal brain ischemia and appears to exacerbate damage. The authors examined effect of gene transfer dominant negative MCP-1, called 7ND, 90 minutes induction hypertensive rats. Adenoviral vectors encoding mutant MCP-1 (Ad7ND; n = 11), or Escherichia coli beta-galactosidase (AdlacZ; 17) as control were injected into lateral ventricle male spontaneously Both AdlacZ (n 12) Ad7ND 6) administration provided...

Tooth agenesis can involve one or more congenitally missing teeth (CMT) and is the most common congenital dental anomalies in humans. reduction of mesiodistal tooth width are reportedly associated, suggesting that pathogenesis two conditions related. The current study analyzed frequency cases hypodontia (1-5 CMT) oligodontia (≥ 6 Japanese patients based on hypothesis reductions frequently associated with than hypodontia.Japanese were divided into (60 female 25 male, mean age 19.6 years, CMT...

Investigating the morphological and functional effects on mandibular asymmetry (MA) is important not only to understand developmental process of masticatory dysfunction, but also provide suggestions for evidence-based occlusal treatment. To evaluate three-dimensional temporomandibular joint (TMJ) morphology its relationship asymmetrical condylar movement in MA patients. Fifty subjects were divided into control groups (n = 25 each) according a menton deviation 4 mm from mid-sagittal plane....

Background and Purpose —Gene therapy may be a promising approach for treatment of brain ischemia, although protein synthesis is generally inhibited in ischemic conditions. Our goal this study was to examine effects ischemia on transgene expression adenovirus-mediated gene transfer brain. Methods —Brain produced by photochemical occlusion the distal middle cerebral artery spontaneously hypertensive rats (n=15). Ninety minutes after adenoviral vectors encoding bacterial β-galactosidase were...

Although it has been suggested that an imbalance in buccolingual pressure may play a role dental compensation of the molars and asymmetry mandibular arch subjects with facial asymmetry, is still unclear whether associated this phenomenon. Thus, purpose study was to test null hypothesis there are no differences cheek tongue between shifted non-shifted sides 12 (8 females 4 males, mean age: 24.9 years) defined as mm or more deviation midline incisors. The resting on bilateral first measured...

The peri-oral muscles-including orbicularis oris-are critical in maintaining equilibrium tooth position. Lip incompetence (LI) can thus be a factor malocclusion. We therefore aimed to validate technique evaluate not only muscle activity via electromyography (EMG) but also endurance and fatigue blood flow (BF) for LI.

Although it has been suggested that adult patients with facial asymmetry posterior unilateral crossbite (PUXB) may have a more tilted mandibular hinge axis (MHA) than those without PUXB, whether craniofacial morphology is associated the MHA remains unclear. The purpose of this study was to compare and in subjects post-growth PUXB.Thirty pre-orthodontic (PUXB non-PUXB groups, n = 15 each, 9 females 6 males, mean age: 23.2 years) participated study. measured by computerized axiography...

Understanding the mechanism of mandibular asymmetry (MA) is important to provide suggestions for occlusal treatment and know developmental process masticatory dysfunction. To investigate morphological functional effects on MA, we evaluated three-dimensional position glenoid fossa its relationship asymmetrical condylar translational movement.In this retrospective study, 50 subjects who previously underwent computed tomography surgical purposes were divided into MA control groups according a...

Deglutitive motion of the tongue may function to maintain tooth position. However, causation between abnormal patterns orofacial muscle and dental malocclusion remains unclear. To clarify pathogenic mechanism malocclusion, it is important determine relative positional relationship tip incisor edge or dorsal palate during deglutition. Here, we assessed utility 3-T segmented cine-magnetic resonance (MR) imaging, combined with static MR images for hard tissue visualization, in assessing...

Background Schizophrenia is a major mental disorder, with an estimated incidence of 1%. Since they are sensitive to sensory changes, orthodontic treatment move teeth should be avoided as aggressively possible in these patients because strong concerns about the possibility causing adverse psychological effects, thus there few reports on for schizophrenia patients. We report case severe open bite caused by medication after onset schizophrenia, even though patient’s occlusion had been stable...

Structured Abstract Authors – Hashimoto K, Otsuka R, Minato A, Sato‐Wakabayashi M, Takada J, Inoue‐Arai MS, Miyamoto JJ, Ono T, Ohyama Moriyama K Objectives To investigate the short‐term effects of maxillary distraction osteogenesis (DO) on temporomandibular joint (TMJ) function in 21 subjects with cleft lip and palate (CLP). Design Morphological changes maxillofacial region were measured using lateral cephalometric radiographs taken immediately before (pre‐DO) after DO (post‐DO) 1 year...

We recently reported that picomolar doses of norethindrone (NET), a synthetic analog 19-nortestosterone, significantly stimulated human TE85 osteosarcoma cell proliferation, differentiation, and activity in vitro. In the present study, we investigated possibility NET interacts with another osteogenic agent, i.e., fluoride, to stimulate activities. Bone proliferation was measured by stimulation [3H]thymidine incorporation. Differentiation monitored increase alkaline phosphatase-specific...

Although the electromyographic (EMG) activity of perioral muscles, including orbicularis oris and mentalis has been described in individuals with lip incompetence during sealing, blood flow through these muscles remains to be elucidated. The purpose this study was examine associated EMG using laser speckle imaging incompetence.Blood superior inferior were measured lips contact (C condition) apart (O (experimental) control subjects (n = 15 each group; mean age: 29.5 years). change ratios C...

To determine the effect of an imbalance in buccolingual pressure that may be involved molar dental compensation mandible and asymmetry arch subjects with facial asymmetry.We performed simultaneous measurement on mandibular right first when without experimentally shifted laterally. Buccolingual pressures rest position (RP), right-shifted (RS), left-shifted (LS) were compared. Moreover, T1-weighted magnetic resonance images obtained RP, RS, LS.Tongue tended to decrease order LS > RP while...