A5102891954- Natural Antidiabetic Agents Studies
- Ion channel regulation and function
- Metabolism, Diabetes, and Cancer
- Ginkgo biloba and Cashew Applications
- Neonatal and fetal brain pathology
- Neonatal Health and Biochemistry
- Iron Metabolism and Disorders
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Studies
- Cancer, Hypoxia, and Metabolism
- Bioactive natural compounds
- Retinal Diseases and Treatments
- Antimicrobial Peptides and Activities
- Ion Channels and Receptors
- Pain Mechanisms and Treatments
- Neurobiology and Insect Physiology Research
- Renal and related cancers
- Fungal Biology and Applications
- Pharmacological Effects and Assays
- Biopolymer Synthesis and Applications
- Autophagy in Disease and Therapy
- Cancer therapeutics and mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Bone Metabolism and Diseases
- Metabolism and Genetic Disorders
Nanjing Drum Tower Hospital
2025
Chengdu Fifth People's Hospital
2021
South Central Minzu University
2017-2020
Fifth Affiliated Hospital of Sun Yat-sen University
2010
Sun Yat-sen University
2010
Nantong University
2007-2008
Hong Kong Polytechnic University
2000-2008
Hebei Normal University
2004
Scope The number of people with diabetes is increasing rapidly in the world. In present study, hypoglycemic activity and potential mechanism ergosterol (ERG), a phytosterol derived from edible mushroom Pleurotus ostreatus are investigated vitro vivo. Methods results ERG isolated identified by NMR spectra. effects on glucose uptake, transporter 4 (GLUT4) translocation, GLUT4 expression, phosphorylation AMPK, Akt PKC L6 cells evaluated. enhances uptake displays translocation up‐regulating...
Glucose transporter 4 (GLUT4) is involved in regulating glucose uptake striated muscle, liver and adipose tissue. Neferine a dibenzyl isoquinoline alkaloid derived from dietary lotus seeds has multiple pharmacological effects. Therefore, this study investigated neferine's role translocation to cell surface, GLUT4 expression. In our study, neferine upregulated expression, induced plasma membrane fusion, increased intracellular Ca2+, promoted alleviating insulin resistance L6 cells....
Abstract Transferrin and transferrin receptor are two key proteins of iron metabolism that have been identified to be hypoxia‐inducible genes. Divalent metal transporter 1 (DMT1) is also a under physiological conditions. In addition, in the 5′ regulatory region human DMT1 (between −412 −570), there motifs (CCA A GTGCT GGG) similar factor‐1 (HIF‐1) binding sites. It was therefore speculated might gene. We investigated effects hypoxia hypoxia/re‐oxygenation on expression content HIF‐1alpha...
Abstract We hypothesized that the neuroprotective role of standardized Ginkgo biloba (Ginkgoaceae) extract EGb 761 under hypoxic conditions might be associated with its function to increase HIF‐1 activity based on fact oxygen availability is crucial for cellular metabolism and viability plays an essential in homeostasis conditions. In this study, we therefore investigated effects ginkgolides, main constituent non‐flavone fraction 761, content HIF‐1α, a key factor determine activity, PC12...
The number of patients with type 2 diabetes mellitus (T2DM) is increasing rapidly worldwide. Glucose transporter 4 (GLUT4) one the main proteins that transport blood glucose into cells and a target in treatment T2DM. In this study, we investigated mechanism action dandelion chloroform extract (DCE) on uptake L6 cells. consumption cell culture supernatant was measured by assay kit, dynamic changes intracellular GLUT4 calcium (Ca2+) levels were monitored laser scanning confocal microscopy...
In today's world, diabetes mellitus (DM) is on the rise, especially type 2 (T2DM), which characterized by insulin resistance. T2DM has high morbidity, and therapies with natural products have attracted much attention in recent past. this paper, we aimed to study hypoglycemic effect mechanism of an ethanolic extract Folium Sennae (FSE) L6 cells. The glucose uptake cells was investigated using a assay kit. We studied transporter 4 (GLUT4) expression AMP-activated protein kinase (AMPK), B...
The effect of asphyxia on iron metabolism and lipid peroxidation in newborn infants with hypoxic-ischemic encephalopathy (HIE) was investigated. Non-protein-bound (NPBI) (thiobarbituric-acid-reactive species; TBARS) plasma hematological indices were measured 15 healthy (mean gestational age 39 04 weeks, SD 1); asphyxiated without neurological abnormalities (AS-HIE; mean 38.8 0.9); (AS+HIE; 39.75 1.4). Follow-up performed at the 5 months. It found that detectable rates NPBI 10 AS-HIE group 13...
Abstract Transferrin (Tf), a naturally existing protein, has received considerable attention in the area of drug targeting since it is biodegradable, non‐toxic, and non‐immunogenic. The efficient cellular uptake Tf shows potential delivery anti‐cancer drugs, proteins, therapeutic genes into proliferating malignant cells that overexpress transferrin receptor (TfR). In human serum, about 30% exists iron‐saturated form (Fe 2 ‐Tf) remainder as apotransferrin (apo‐Tf). Understanding apo‐Tf by...
Our results indicated that CNPL exhibits anti-diabetic effects in KK-Ay mice<italic>via</italic>activating AMP-activated kinase and regulating PPARγ.
ADVERTISEMENT RETURN TO ISSUEPREVArticleFormation and Repair of Antitumor Antibiotic CC-1065-Induced DNA Adducts in the Adenine Phosphoribosyltransferase Amplified Dihydrofolate Reductase Genes Chinese Hamster Ovary CellsMoon Shong Tang, Ming Qian, Annie PaoCite this: Biochemistry 1994, 33, 9, 2726–2732Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March...
Abstract Background Asthma is one of the main intractable diseases recognized by international medical community. The current widely used bronchodilators for asthma—β2-adrenal receptor agonists—have limited therapeutic effects, necessitating development novel antiasthma drugs with increased efficacy and fewer adverse effects. In this study, we investigated relaxant effects underlying mechanism an ethyl acetate extract from dandelion (EAED) on mouse airway smooth muscle. Methods EAED...
Objective To study the effect and mechanism of serum carrying Fortune's drynaria rhizome chomocor on proliferation, differentiation, mineralization osteoblast new-born SD rats. Methods (1) Preparation chromocor: chromocor was administered once everyday for continuous 12 days to months old female Blood obtained from aorta. (2) Creation experiment model; Isolated neonatal rats' calvaria by using enzyme digestion twice, subcultured. The third passage cultured chosen as model. (3) Index; ①The...
Abstract Backgrond: Asthma is one of the intractable diseases recognized by world medical community. The current widely used bronchodilators β2-adrenal receptor agonists for asthma have limited therapeutic effects, which make it necessary to develop novel drugs with increased efficacy but fewer side-effects antiasthma treatments. In this study, we attempted investigate relaxing effects and mechanism an ethyl acetate extract from dandelion (EAED) on mouse airway smooth muscle (ASM). Methods:...
Abstract Background: Asthma is one of the main intractable diseases recognized by international medical community. The current widely used bronchodilators for asthma—β2-adrenal receptor agonists—have limited therapeutic effects, necessitating development novel antiasthma drugs with increased efficacy and fewer adverse effects. In this study, we investigated relaxant effects underlying mechanism an ethyl acetate extract from dandelion (EAED) on mouse airway smooth muscle. Methods: EAED...
Abstract Background: Asthma is one of the main intractable diseases recognized by international medical community. The current widely used bronchodilators for asthma—β2-adrenal receptor agonists—have limited therapeutic effects, necessitating development novel antiasthma drugs with increased efficacy and fewer adverse effects. In this study, we investigated relaxant effects underlying mechanism an ethyl acetate extract from dandelion (EAED) on mouse airway smooth muscle. Methods: EAED...