A5101913732- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inhalation and Respiratory Drug Delivery
- COVID-19 Clinical Research Studies
- Sarcoidosis and Beryllium Toxicity Research
- Medical Imaging and Pathology Studies
- Occupational exposure and asthma
- Long-Term Effects of COVID-19
- Venous Thromboembolism Diagnosis and Management
- SARS-CoV-2 and COVID-19 Research
- Neutropenia and Cancer Infections
- Cancer Genomics and Diagnostics
- Pleural and Pulmonary Diseases
- Tumors and Oncological Cases
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myeloid Leukemia Research
- Antimicrobial Resistance in Staphylococcus
- Vitamin K Research Studies
- Chromatin Remodeling and Cancer
- Cancer Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Vascular Anomalies and Treatments
- Antifungal resistance and susceptibility
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Cardiovascular Syncope and Autonomic Disorders
Tokyo Medical and Dental University
2020-2024
The University of Tokyo
2021
Juntendo University
2021
Tokyo Medical and Dental University Hospital
2021
Toho University
1986-1993
Kyoto University
1981
SMARCA4-deficient thoracic sarcoma is a rare tumor typically presenting as mediastinal mass. The prognosis estimated to be poor, and no effective treatment has been established. We present case of 76-year-old man who was diagnosed with sarcoma. provisional diagnosis carcinoma unknown primary but subsequently corrected based on the panel-based cancer gene screening immunohistochemistry. Cytotoxic chemotherapy first- second-line did not reveal enough therapeutic effects third-line therapy...
Background: Thrombosis is a characteristic complication in coronavirus disease 2019 (COVID-19). Since coagulopathy has been observed over the entire clinical course, thrombosis might be clue to understanding specific pathology COVID-19. Currently, there limited epidemiological data of COVID-19-associated Japanese population and none regarding variant strains SARS-CoV-2. Here, we elucidate risk factors pattern COVID-19 patients. Methods: The patients consecutively admitted Tokyo Medical...
Abstract Background Exposure assessment is integral to the diagnosis of hypersensitivity pneumonitis (HP). Although clinical relevance exposed antigens essential for assessment, many previous guidelines or reports have only evaluated simple exposure histories immunological tests. To overcome this problem, Assessment Form (EAF) was developed as an tool classifying grade from G0 G4. The EAF modified description in Japanese practice guide 2022 HP published by Respiratory Society. Methods One...
Abstract Background The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has increased the incidence community-onset MRSA infection. Respiratory tract infections caused by been noted for their severity; however, repeated relapses that require extended antibiotic therapy are rare. Case presentation We report a case relapsing bronchopneumonia CA-MRSA in 56-year-old man. patient responded to antibiotics, but repeatedly relapsed after stopping treatment....
Pneumothorax is a rare but life-threatening complication associated with pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Informed consent was obtained from the patient himself.A 50-year-old man presented 9-day history of fever, cough, and dyspnoea. He diagnosed disease 2019 (COVID-19) admitted to Medical Hospital, Tokyo Dental University. Chest CT showed diffuse patchy ground-glass opacities (GGOs). His state oxygenation deteriorated, mechanical ventilation...
We herein report a rare case of hypersensitivity pneumonitis (HP) that was initially demonstrated as solitary pure ground-glass opacity (GGO) on chest computed tomography (CT). A 51-year-old woman with history breast cancer underwent follow-up CT, which revealed GGO. The patient developed exertional dyspnea after two years, and CT diffuse centrilobular nodules in addition to GGO, had increased size. An antigen avoidance test performed diagnose HP, leading the resolution abnormalities,...
Nontuberculous mycobacterial (NTM) infection sometimes leads to the development of pulmonary artery aneurysm (PAA), a rare but life-threatening complication. We herein report 64-year-old woman with history NTM who presented severe hemoptysis. Computed tomography revealed ruptured PAA, which was treated successfully embolization. Subsequent right total pneumonectomy performed control infection. This case emphasizes need consider PAA in patients present Early detection and appropriate...
Anticoagulant therapy for patients with severe coronavirus disease (COVID-19) pneumonia is considered to improve the hypercoagulable and inflammatory state. However, bleeding complications should also be considered.A 77-year-old man a history of falls was diagnosed COVID-19. Owing his condition, he intubated transferred our hospital intensive care. Favipiravir, tocilizumab, unfractionated heparin, ART-123 were administered treat COVID-19 manage antithrombotic prophylaxis paroxysmal atrial...
Factors associated with mortality are important in the treatment of coronavirus disease 2019 (COVID-19). Polymerase chain reaction (PCR) is gold standard for diagnosing COVID-19, which reflects viral load upper respiratory tract. In total, 523 patients were enrolled this study; them, 441 and 75 underwent PCR testing nasopharyngeal swabs sputum samples, respectively, within 20 days from onset COVID-19. We investigated association between RNA copy number COVID-19 severity rate its effect on...
Abstract Background Exposure assessment is integral to the diagnosis of hypersensitivity pneumonitis (HP). Although clinical relevance exposed antigens essential for assessment, many previous guidelines or reports have only evaluated a simple exposure history immunological test. To overcome this problem, Assessment Form (EAF) was developed as an tool classifying grade from G0 G4. The EAF modified description in HP published by Japanese Respiratory Society. Methods One hundred and seventy-two...
Abstract Background and Objectives: Obstructive sleep apnea (OSA) is known to be one of the common complications interstitial lung disease (ILD). Although it suspected that incidence OSA progression ILD are closely related each other, clinical features with such not fully understood. The aim this study clarify specific factors in patients predict complication severity OSA. Study Design Method: our institute were prospectively investigated for by polysomnography (PSG). Results: All 33...
Background: Interstitial lung diseases (ILDs) consist with heterogeneous group of disorders significant morbidity and mortality.Recent clinical trials prospective cohort studies described the demographic prognosis representative subtypes ILDs such as idiopathic pulmonary fibrosis (IPF) connective tissue disease related (CTD-ILDs).However, there are little reports real-world cohorts including entire ILD population.Methods: Retrospective database was generated based on medical record Nagoya...
antifibrotic treatment (AFT) in patients with idiopathic pulmonary fibrosis (IPF).Methods: Among IPF who received AFT between 2009 and 2019, we assessed the extracted data including age, sex, Charlson Comorbidity Index score (CCIS), blood biomarker, function test results high-resolution CT findings at starting AFA disease outcomes acute exacerbation or death.Results: We 166 (median 75 years).Eighty-seven nintedanib, 76 pirfenidone, 3 both.During follow-up, 42 (25%) experienced (AE).The 3-yr...