A5103192273- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- Trauma Management and Diagnosis
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Issues in Pregnancy
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
- Diabetes and associated disorders
- Cardiac Arrest and Resuscitation
- Dental Health and Care Utilization
- Urticaria and Related Conditions
- Vasculitis and related conditions
- Head and Neck Surgical Oncology
- Dental Erosion and Treatment
- Chronic Disease Management Strategies
- Contact Dermatitis and Allergies
- Nerve injury and regeneration
- Phagocytosis and Immune Regulation
- Ocular Diseases and Behçet’s Syndrome
- Melanoma and MAPK Pathways
- Drug-Induced Adverse Reactions
- Poisoning and overdose treatments
- Clinical practice guidelines implementation
- Long-Term Effects of COVID-19
- interferon and immune responses
National Institute of Infectious Diseases
2025
The University of Tokyo
2021-2024
Tokyo Medical and Dental University
2021-2024
Asahikawa Medical University
2012-2022
Showa University
2018-2019
VA Ann Arbor Healthcare System
2017
University of Michigan
2017
Background: Thrombosis is a characteristic complication in coronavirus disease 2019 (COVID-19). Since coagulopathy has been observed over the entire clinical course, thrombosis might be clue to understanding specific pathology COVID-19. Currently, there limited epidemiological data of COVID-19-associated Japanese population and none regarding variant strains SARS-CoV-2. Here, we elucidate risk factors pattern COVID-19 patients. Methods: The patients consecutively admitted Tokyo Medical...
Obesity has been recognized as one of the most significant risk factors for deterioration and mortality associated with COVID-19, but significance obesity itself differs among ethnicity. Multifactored analysis our single institute–based retrospective cohort revealed that high visceral adipose tissue (VAT) burden, not other obesity-associated markers, was related to accelerated inflammatory responses Japanese COVID-19 patients. To elucidate mechanisms how VAT-dominant induces severe...
Background Thrombosis is a unique complication of coronavirus disease 2019 (COVID-19). Although antiphospholipid antibodies (aPL) are detected in COVID-19 patients, their clinical significance remains elusive. We evaluated the prevalence aPL and serum concentrations beta-2 glycoprotein I (β2GPI), major self-antigen for aPL, Japanese patients with without thrombosis. Methods This retrospective single-center nested case-control study included 594 hospitalized between January 2020 August 2021....
Dental calculi formation on dentures can worsen the oral cavity environment by complicating hygiene. However, few studies have investigated effect of how patients use and manage their dentures, denture surface roughness, host factors such as dryness saliva properties cleanliness dental formation. Accordingly, we conducted present survey to evaluate these clarify strength influence each factor. We enrolled 53 who had used for at least 3 months a prosthesis that covered six front teeth...
Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating complication associated with drug treatment of cancer for which there are no effective strategies prevention or treatment. In this study, we examined the effect intermittent expression neurotophin-3 (NT-3) interleukin-10 (IL-10) from replication-defective herpes simplex virus (HSV)-based regulatable vectors delivered by subcutaneous inoculation to dorsal root ganglion (DRG) on development paclitaxel-induced neuropathy. We...
Ia群抗不整脈薬シベンゾリンを含む処方薬を過量服用し,心停止を来した症例を経験したので報告する。症例は10歳代後半,男性。家族に処方されていたシベンゾリン100 mg 30錠,バルプロ酸200 118錠,ブロチゾラム0.25 28錠,イブプロフェン100 34錠を自宅で服用した。内服から70分後に当院救命センターへ搬送された。心電図は完全右脚ブロック波形であったが当初循環は保たれていた。しかし,来院15分後より心室頻拍(ventricular tachycardia, VT)となり,やがてpulseless electrical activity(PEA)となった。心肺蘇生(cardiopulmonary resuscitation, CPR)に反応しないため経皮的心肺補助装置(percutaneous cardiopulmonary support,...
Tampo, A.1; Yamaki, M.1; Kawata, D.1; Suzuki, A.2; Akasaka, N.1; Fujita, S.1 Author Information
Abstract Behcet's disease (BD) is a multisystem immune‐mediated inflammatory disorder that occasionally involves the gastrointestinal tract. Reports on involvement of BD are relatively rare, which gastroduodenal particularly rare. Endoscopic features lesions unknown, and treatment strategies have not been established. In this report, we present case 72‐year‐old female with who presented extensive ulcers hematemesis were resistant to colchicine corticosteroid treatment, subsequently...
This study was performed to evaluate the usefulness of a developed clinical pathway (CP) determine sequence dental treatment in patients who are edentulous and use maxillary mandibular complete dentures. Sixty-two with dentures were randomly allocated either (31 subjects) or without CP. The main categories CP examination, instructions, practice, idle time, evaluation sheet, preparation, other steps. subcategories made respect categories. participants categorized as dentists, assistants,...
Toxic epidermal necrolysis (TEN) and severe burns both have high mortality rates, but coexistence is extremely rare. The specificity of developing TEN in burn patients not well understood its treatment strategy established.A 68-year-old man was carried to our hospital with covering 35% his body surface area. He developed bacteremia during required antimicrobial therapy. However, erythema appeared on the trunk upper limbs rapidly spread extremities, leading a diagnosis TEN. rash gradually...
個別の核酸増幅検査（NAT）で検出し得なかったB型肝炎ウイルス（HBV）を含む血液の輸血によるHBV感染症例を経験した．交通外傷による多臓器損傷が認められた20歳代男性に対し，赤血球濃厚液を24単位（12ドナー），新鮮凍結血漿を16単位（8ドナー），および，濃厚血小板を35単位（2ドナー）使用した．輸血後感染症検査でHBV-DNAが陽性であったため，輸血前保存検体の検査を行ったが，HBV関連マーカー（HBs抗原，HBs抗体，HBc抗体）はすべて陰性であった．供血した22ドナーの保管検体の個別NATもすべて陰性であったが，そのうちの1人は再度の献血で，NATが陽転化した．HBc抗体弱陽性でもあったため，occult HBV carrierとみなされた．輸血による感染の発端はこのドナー由来のFFPであった．現在の検査感度や日赤の輸血用血液の可否基準ではoccult carrierからの血液を確実に排除することは困難である．適正に輸血を行ってもウイルスに感染する可能性があるため，その感染と輸血との因果関係を証明するためには輸血前検体保存が必須である．
Background Thrombosis is a unique complication in coronavirus disease 2019 (COVID-19). We have reported that elevated ferritin and D-dimer on admission were the risk factors of thromboses by analyzing patients sequentially admitted to our hospital due COVID-19 (1). However, we not analyzed thrombotic complications view antiphospholipid antibodies (aPLs), which are frequently detected patients. Objectives To elucidate thrombogenic effects aPLs COVID-19, development thrombosis three lupus...
Abstract Obesity is one of the most significant risk factors for deterioration and mortality associated with COVID-19 [1]. A certain proportion patients experience marked elevations inflammatory mediators, termed “cytokine storm”, resulting in respiratory condition [2,3]. In present study, we elucidate that high visceral adipose tissue (VAT) burden was more closely related to accelerated responses Japanese than other obesity-associated markers, including body mass index (BMI). To explore a...
Group G Streptococcus (GGS) causes toxic shock syndrome. Its incidence has been increasing in the elderly recent years. The case is a female patient her 60s, with rheumatoid arthritis, who developed necrotizing fasciitis right thigh. We administered antibacterial agents and debridement frequently at an early stage, followed by aggressive high-protein enteral nutrition multidisciplinary treatment. During course of treatment, patient’s general condition temporarily deteriorated because fecal...