A5027880749- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Neurobiology of Language and Bilingualism
- Functional Brain Connectivity Studies
- Neurological Disorders and Treatments
- Cognitive Functions and Memory
- Health and Medical Research Impacts
- Ginkgo biloba and Cashew Applications
- Neurological Disease Mechanisms and Treatments
- Cognitive Abilities and Testing
- Nutrition, Genetics, and Disease
- RNA regulation and disease
- Advanced MRI Techniques and Applications
- Assistive Technology in Communication and Mobility
- Intensive Care Unit Cognitive Disorders
- Multiple Sclerosis Research Studies
- Frailty in Older Adults
- Delphi Technique in Research
- Neurological disorders and treatments
- Aging, Elder Care, and Social Issues
- Neurology and Historical Studies
- Health, Environment, Cognitive Aging
- Memory and Neural Mechanisms
- Diet and metabolism studies
Camden and Campbelltown Hospitals
2023-2024
Western Sydney University
2022-2024
The University of Sydney
2015-2022
Mind Australia
2017-2018
Physical and cognitive exercise may prevent or delay dementia in later life but the neural mechanisms underlying these therapeutic benefits are largely unknown. We examined structural functional magnetic resonance imaging (MRI) brain changes after 6 months of progressive resistance training (PRT), computerized (CCT) combined intervention. A total 100 older individuals (68 females, average age=70.1, s.d.±6.7, 55–87 years) with prodrome mild impairment were recruited SMART (Study Mental...
The increased understanding that neuropathology begins decades before symptom onset, has led to the conceptualization and widespread utilization of Mild Cognitive Impairment (MCI) as an important transitional state between healthy aging dementia. Further subcategorization MCI subtype more distinct prognoses it is widely considered amnestic non-amnestic (aMCI, naMCI) likely have pathophysiologies. Yet, accurately classification remains contentious. Here, we differentiate hippocampal subfield...
Despite representing an essential workforce, it is unclear how global policy efforts target early-career dementia researchers (ECDRs). Thus, this study aimed to provide overview of policies through which ECDRs are considered and supported by plans organizations.
Vascular dementia (VaD) accounts for 15–20% of all cases. It is a syndrome acquired cognitive impairment with complex pathophysiological basis. A novel herbal formulation (Sailuotong; SLT) consisting Panax ginseng C . Mey , Ginkgo biloba L and Crocus sativus extracts was developed to treat VaD. Preclinical animal studies found significant improvements in memory pathogenic biochemical parameters. Appropriate safety SLT shown acute chronic toxicity studies, early clinical trials demonstrated...
Abstract Background Early career dementia researchers (ECDRs) represent a crucial workforce to drive research. Many charities, research leaders, and pressure groups, along with people living dementia, continue advocate for greater investment in It remains unclear how ECDRs are being supported this push through top‐down policy approaches. This study aimed understand considered by national plans or strategies across countries, dementia‐specific charities associations. Method Forty‐six...
Computerised cognitive training (CCT) is a safe and scalable intervention with established efficacy in healthy older adults those mild impairment. However, it unclear whether CCT can reverse trajectories people an insidious course of decline, population at ultra-high risk for developing dementia. Eighty-six memory clinic patients documented decline (at least 0.5 SD performance between two follow-ups) are currently recruited to randomised, active controlled trial. Participants randomly...
Rapid development and evaluation of interventions to modify ageing-related cognitive decline is key for global efforts prevent dementia. Computerised training (CCT) a popular safe intervention enrichment in older adults. CCT has been illustrated be efficacious improving overall cognition variety populations including healthy adults, MCI PD. However, as effective masking the therapeutic effect challenging blinding participants implausible, it difficult quantify contribution non-specific...
Computerised Cognitive Training (CCT) is a safe and scalable intervention to maintain enhance cognition in older adults. Yet effect differences across domains, target populations specific CCT methods are largely unknown. We conducted series of systematic reviews randomised controlled trials (RCTs) healthy adults, mild cognitive impairment (MCI), Parkinson's disease (PD), dementia. Meta-analyses investigated post-training effects transfer functional outcomes sources bias, contrasted results...
Subcategorization of mild cognitive impairment (MCI) into the clinical phenotypes amnestic and non-amnestic MCI (aMCI naMCI) has shown that aMCI is associated with yet an even higher risk conversion to AD. aMCI, naMCI likely have distinct pathophysiologies disease trajectories. Therefore, accurate characterisation subtyping particularly important both from aetiological as well prognostic perspectives. By utilising a stringent approach distinguishing vs. naMCI, we aim a) identify whether this...
The hippocampus is one of the earliest affected structures in Alzheimer's disease and known for its critical role new learning memory consolidation. Early signs deterioration are often reflected via decrements retention those most at risk developing dementia, namely with Mild Cognitive Impairment (MCI). This study aimed to examine relationship between hippocampal subfield volumes visuospatial as well verbal individuals MCI, (MCI+DEP) without (MCI) a history major depression. In total, 82...
ABSTRACT Background Vascular dementia (VaD) accounts for 15-20% of all cases. It is a syndrome acquired cognitive impairment with complex pathophysiological basis. A novel herbal formulation (Sailuotong; SLT) consisting Panax ginseng, Ginkgo biloba and Crocus sativus extracts was developed to treat VaD. Preclinical animal studies found significant improvements in memory pathogenic biochemical parameters. Appropriate safety SLT shown acute chronic toxicity studies, early clinical trials...
Hippocampal subfield volume loss in older adults with amnestic mild cognitive impairment (aMCI) and depression history are associated amyloid beta tau pathology, thereby increasing the risk for Alzheimer's disease (AD). However, no studies have exclusively examined distinct alterations hippocampal subfields non-amnestic MCI (naMCI) relation to history. Here, we used both longitudinal transverse segmentation methods using automated FreeSurfer software examine whether a lifetime is differences...