A5045686335- Lymphatic System and Diseases
- Allergic Rhinitis and Sensitization
- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- Entomological Studies and Ecology
- RNA and protein synthesis mechanisms
- Polyomavirus and related diseases
- Planarian Biology and Electrostimulation
- CRISPR and Genetic Engineering
The Francis Crick Institute
2024
Imperial College London
2020-2024
MRC Laboratory for Molecular Cell Biology
2020-2021
University College London
2020-2021
Maintaining genome integrity is an essential and challenging process. RAD51 recombinase, the central player of several crucial processes in repairing protecting integrity, forms filaments on DNA. are tightly regulated. One these regulators FIGNL1, that prevents persistent foci post-damage genotoxic chromatin association cells. The cryogenic electron microscopy structure FIGNL1 complex with reveals a non-planar hexamer N-terminus enclosed pore. Mutations pore loop or catalytic residues render...
Maintaining genome integrity is an essential and challenging process. RAD51 recombinase, the central player of several crucial processes in repairing DNA protecting integrity, forms filaments on DNA, which are tightly regulated. One these regulators FIGNL1, that prevents persistent foci without or after damage genotoxic chromatin association cells. The cryogenic electron microscopy structure FIGNL1 complex with reveals a non-planar hexamer N terminus enclosure pore. Mutations pore loop...
Melanoma is an aggressive skin cancer developing from melanocytes, frequently resulting in metastatic disease. cells utilize amoeboid migration as mode of local invasion. Amoeboid invasion characterized by rounded cell morphology and high actomyosin contractility driven Rho GTPase signalling. Migrastatic drugs targeting actin polymerization are therefore a promising treatment option for melanoma. To predict potential, biomarkers functionally linked to pathways needed. The glycoprotein...
Melanoma is an aggressive skin cancer developing from melanocytes, frequently resulting in metastatic disease. cells utilise amoeboid migration as mode of local invasion. Amoeboid invasion characterized by rounded cell morphology and high actomyosin contractility driven the RhoA signalling pathway. Migrastatic drugs targeting actin polymerization to inhibit metastasis are therefore a promising treatment option. To predict potential, there need for biomarkers functionally linked pathways. The...
Melanoma is an aggressive skin cancer developing from melanocytes, frequently resulting in metastatic disease. cells utilise amoeboid migration as mode of local invasion. Amoeboid invasion characterized by rounded cell morphology and high actomyosin contractility driven the RhoA signalling pathway. Migrastatic drugs targeting actin polymerization to inhibit metastasis are therefore a promising treatment option. To predict potential, there need for biomarkers functionally linked pathways. The...