A5082392777- Effects and risks of endocrine disrupting chemicals
- Reproductive Biology and Fertility
- Pharmaceutical studies and practices
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Carcinogens and Genotoxicity Assessment
- Animal testing and alternatives
- Sperm and Testicular Function
- Memory and Neural Mechanisms
- Prenatal Screening and Diagnostics
- Pluripotent Stem Cells Research
- Hormonal and reproductive studies
- Antibiotics Pharmacokinetics and Efficacy
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Assisted Reproductive Technology and Twin Pregnancy
- Neuroscience and Neuropharmacology Research
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Adolescent Sexual and Reproductive Health
- Estrogen and related hormone effects
- Prenatal Substance Exposure Effects
- Pharmacological Effects and Toxicity Studies
- HIV/AIDS Research and Interventions
- Epilepsy research and treatment
Janssen (United States)
2022
Bristol-Myers Squibb (United States)
2011-2021
Florida College
2021
University of Florida
2021
The Bristol-Myers Squibb Children's Hospital
2011-2019
Federation of American Societies for Experimental Biology
2019
Stanford University
2019
Toronto Public Health
2018
Bristol-Myers Squibb (Germany)
2015
Tuskegee University
2006-2008
We are coming to appreciate that at fertilization human spermatozoa deliver the paternal genome alongside a suite of structures, proteins and RNAs. Although role some structures as requisite elements for early development has been established, function sperm-delivered RNAs remains point discussion. The presence in transcriptionally quiescent can only be derived from transcription precedes late spermiogenesis. A cross-platform microarray strategy was used assess profile spermatozoal...
Previous studies have shown that ovotoxicity induced in rats by dosing with 4-vinylcyclohexene diepoxide (VCD) is likely via acceleration of the normal rate atresia (apoptosis). The present study was designed to investigate apoptosis-related caspase cascades as a component this phenomenon isolated ovarian small follicles. Female F344 were given single dose VCD (80 mg/kg, i.p., on Day 1; time when has not been initiated), or dosed daily for 15 days 15; significant underway). Ovaries collected...
Current developmental toxicity testing adheres largely to protocols suggested in 1966 involving the administration of test compound pregnant laboratory animals. After more than 50 years embryo-fetal development testing, are we ready consider a different approach human testing?A workshop was held under auspices Developmental and Reproductive Toxicology Technical Committee ILSI Health Environmental Sciences Institute how might design if started over with 21st century knowledge techniques...
Gene expression profiling of whole blood may be useful for monitoring toxicological exposure and diagnosis various diseases. Several methods are available that can used to transport, store, extract RNA from blood, but it is not clear which procedures alter results. In addition, characterization interindividual sex-based variation in gene needed understand sources extent variability.Whole was obtained adult male female volunteers (n = 42) stored at temperatures lengths time. isolated quality...
A database of embryo-fetal developmental toxicity (EFDT) studies 379 pharmaceutical compounds in rat and rabbit was analyzed for species differences based on toxicokinetic parameters area under the curve (AUC) maximum concentration (Cmax) at lowest adverse effect level (dLOAEL). For vast majority cases (83% AUC n = 283), dLOAELs rats rabbits were within same order magnitude (less than 10-fold different) when compared available data Cmax exposures. 13.5% more sensitive 3.5% 12% 1.3% When...
Standard components of nonclinical toxicity testing for novel pharmaceuticals include clinical and anatomic pathology, as well separate evaluation effects on reproduction development to inform labeling. General study designs in regulatory guidances do not specifically mandate use pathology or reproductive end points across all types; thus, inclusion these are variable. The Scientific Regulatory Policy Committee the Society Toxicologic Pathology (STP) formed a Working Group assess current...
We compared a commercially available dot-blot immunoassay system with the indirect immunofluorescence assay (IFA) in tests of known negative and positive sera from scrub typhus cases. Using panel 100 patients various rickettsial nonrickettsial infections, we observed that IFA was 99% specific dipstick 98% specific. In 91 (30 61 for antibodies) study febrile Malaysia, using standard an titer < 1:64 as negative, > 1:128 positive, = either or (supported by clinical records), dipsticks were 83%...