A5102920547- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Animal testing and alternatives
- Immunotoxicology and immune responses
- Toxic Organic Pollutants Impact
- Health, Environment, Cognitive Aging
- Anesthesia and Neurotoxicity Research
- Pharmaceutical studies and practices
- Pesticide Exposure and Toxicity
- Birth, Development, and Health
- Reproductive Biology and Fertility
- Prenatal Substance Exposure Effects
- Chemical Safety and Risk Management
- Molecular Biology Techniques and Applications
- Animal Genetics and Reproduction
- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Rare-earth and actinide compounds
- Thyroid Disorders and Treatments
- Cancer Risks and Factors
- Sperm and Testicular Function
- Pluripotent Stem Cells Research
- Pesticide and Herbicide Environmental Studies
- Copper Interconnects and Reliability
- Congenital limb and hand anomalies
Environmental Protection Agency
2014-2024
Indianapolis Zoo
2018-2023
Triangle
2018-2023
Committee on Publication Ethics
2022-2023
National Center on Birth Defects and Developmental Disabilities
2019-2023
Gainesville Obstetrics & Gynecology
2021-2023
John Wiley & Sons (United States)
2018-2023
Hudson Institute
2023
Liechtenstein Institute
2023
Minneapolis Institute of Arts
2023
Background: In support of the Integrated Risk Information System (IRIS), U.S. Environmental Protection Agency (EPA) completed a toxicological review trichloroethylene (TCE) in September 2011, which was result an effort spanning > 20 years.Objectives: We summarized key findings and scientific issues regarding human health effects TCE EPA's review.Methods: this assessment we synthesized characterized thousands epidemiologic, experimental animal, mechanistic studies, addressed several through...
Abstract This update (Version 2) of the Terminology Developmental Abnormalities in Common Laboratory Mammals ( Version 1 ) by Wise et al. 1997 incorporates improvements and enhancements to both content organization terminology, enable greater flexibility its application, while maintaining a consistent approach description findings. The revisions are result an international collaboration among interested organizations, advised individual experts outcomes several workshops. terminology remains...
Current developmental toxicity testing adheres largely to protocols suggested in 1966 involving the administration of test compound pregnant laboratory animals. After more than 50 years embryo-fetal development testing, are we ready consider a different approach human testing?A workshop was held under auspices Developmental and Reproductive Toxicology Technical Committee ILSI Health Environmental Sciences Institute how might design if started over with 21st century knowledge techniques...
A database of embryo-fetal developmental toxicity (EFDT) studies 379 pharmaceutical compounds in rat and rabbit was analyzed for species differences based on toxicokinetic parameters area under the curve (AUC) maximum concentration (Cmax) at lowest adverse effect level (dLOAEL). For vast majority cases (83% AUC n = 283), dLOAELs rats rabbits were within same order magnitude (less than 10-fold different) when compared available data Cmax exposures. 13.5% more sensitive 3.5% 12% 1.3% When...