A5074732027- Melanoma and MAPK Pathways
- Nanoplatforms for cancer theranostics
- Cellular Mechanics and Interactions
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Synthesis of Tetrazole Derivatives
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- Economic and Financial Impacts of Cancer
Sapienza University of Rome
2021-2023
Abstract BRAF-mutated melanoma relapsing after targeted therapies is an aggressive disease with unmet clinical need. Hence the need to identify novel combination able overcome drug resistance. miRNAs have emerged as orchestrators of non-genetic mechanisms adopted by cells challenge therapies. In this context we previously identified a subset oncosuppressor downregulated in drug-resistant melanomas. Here demonstrate that lipid nanoparticles co-encapsulating two them, miR-199-5p and...
Rationale: Metastatic melanoma is the most aggressive and dangerous form of skin cancer.The introduction immunotherapy with Immune checkpoint Inhibitors (ICI) targeted therapy BRAF MEK inhibitors for mutated melanoma, has greatly improved clinical outcome these patients.Nevertheless, response to remains highly variable development drug resistance continues be a daunting challenge.Within this context there need develop diagnostic tools capable predicting or in order select best therapeutic...
Abstract Background BRAF-mutant melanoma patients benefit from the combinatorial treatments with BRAF and MEK inhibitors. However, acquired drug resistance strongly limits efficacy of these targeted therapies in time. Recently, many findings have underscored involvement microRNAs as main drivers resistance. In this context, we previously identified a subset oncomiRs up-regulated drug-resistant melanomas. work, shed light on molecular role two yet poorly characterized oncomiRs, miR-4443...
Abstract The integration of telemedicine tools such as teleconsultation and telemonitoring in cancer patients care may allow to improve person-centered patients’ empowerment. eCAN JA (https://ecanja.eu/) explores the role clinical trials focusing on tele-rehabilitation tele-psychological support different populations 10 European countries.The main aim is assess effect program focused rehabilitation psychological for patient reported outcomes measures (PROMs) three pilot randomized controlled...