A5003047670- Monoclonal and Polyclonal Antibodies Research
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Click Chemistry and Applications
- Alzheimer's disease research and treatments
- Head and Neck Cancer Studies
- Chemical Synthesis and Analysis
- Diabetes and associated disorders
- Endoplasmic Reticulum Stress and Disease
- Protein Structure and Dynamics
- Carbon and Quantum Dots Applications
- Galectins and Cancer Biology
- Graphene and Nanomaterials Applications
- Immune Cell Function and Interaction
- Oral Health Pathology and Treatment
- Drug Transport and Resistance Mechanisms
- Interpreting and Communication in Healthcare
Australian Regenerative Medicine Institute
2019-2022
Monash University
2019-2022
Vellore Institute of Technology University
2018-2019
Discovery Institute
2019
Abstract Antigen recognition by CD8+ T cells is governed the pool of peptide antigens presented on cell surface in context HLA class I complexes. Studies have shown not only a high degree plasticity immunopeptidome, but also that considerable fraction all peptides generated through proteasome-mediated splicing noncontiguous regions proteins to form novel antigens. Here, we used high-resolution mass spectrometry combined with new bioinformatic approaches characterize immunopeptidome melanoma...
Introduction Demographic, behavioural and environmental factors have been associated with increased risk of head neck cancer (HNC). We will review published reports explore connections between HNC incidence. This protocol aims to provide strategies for a systematic meta-analysis factor analysis in India. It also provides guidelines order visualise obtained data the form heat-map highlighting variations across gender, age geographical location. Methods identify well-established perform...
Alzheimer's disease (AD) is the most severe form of neurological disorder, characterized by presence extracellular amyloid-β (Aβ) plaques and intracellular tau tangles. For decades, therapeutic strategies against pathological symptoms AD have often relied on delivery monoclonal antibodies to target specifically Aβ amyloid or oligomers, largely no avail. can be traced in brain as well cerebrospinal fluid circulation, giving rise abundant opportunities interact with their environmental...
How immune tolerance is lost to pancreatic β-cell peptides triggering autoimmune type 1 diabetes enigmatic. We have shown that loss of the proinsulin chaperone glucose-regulated protein (GRP) 94 from endoplasmic reticulum (ER) leads mishandling proinsulin, ER stress, and activation immunoproteasome. hypothesize inadequate folding capacity relative biosynthetic need may lead an altered major histocompatibility complex (MHC) class-I bound peptidome inflammasome activation, sensitizing β-cells...
Summary Antigen-recognition by CD8 + T cells is governed the pool of peptide antigens presented on cell surface in context HLA class I complexes. Recent studies have shown not only a high degree plasticity immunopeptidome, but also that considerable fraction all peptides generated through proteasome-mediated splicing non-contiguous regions proteins to form novel antigens. Here we used high-resolution mass-spectrometry combined with new bioinformatic approaches characterize immunopeptidome...
<div>Abstract<p>Antigen recognition by CD8<sup>+</sup> T cells is governed the pool of peptide antigens presented on cell surface in context HLA class I complexes. Studies have shown not only a high degree plasticity immunopeptidome, but also that considerable fraction all peptides generated through proteasome-mediated splicing noncontiguous regions proteins to form novel antigens. Here, we used high-resolution mass spectrometry combined with new bioinformatic...
<div>Abstract<p>Antigen recognition by CD8<sup>+</sup> T cells is governed the pool of peptide antigens presented on cell surface in context HLA class I complexes. Studies have shown not only a high degree plasticity immunopeptidome, but also that considerable fraction all peptides generated through proteasome-mediated splicing noncontiguous regions proteins to form novel antigens. Here, we used high-resolution mass spectrometry combined with new bioinformatic...
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<p>Supplementary Figures S1-S10</p>
<p>Supplementary Figures S1-S10</p>
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