A5042119467- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Neurotransmitter Receptor Influence on Behavior
- Schizophrenia research and treatment
- Metabolism and Genetic Disorders
- Neural dynamics and brain function
- Neurological disorders and treatments
- Gastric Cancer Management and Outcomes
- Treatment of Major Depression
- Autism Spectrum Disorder Research
- Stress Responses and Cortisol
- Colorectal Cancer Surgical Treatments
- Epigenetics and DNA Methylation
- Obsessive-Compulsive Spectrum Disorders
- Amino Acid Enzymes and Metabolism
- Bioinformatics and Genomic Networks
- Sleep and related disorders
- Gastrointestinal Tumor Research and Treatment
- Mental Health Research Topics
- Colorectal Cancer Screening and Detection
- Phosphodiesterase function and regulation
- Mitochondrial Function and Pathology
University of Naples Federico II
2022-2025
Federico II University Hospital
2023-2025
Departament de Salut
2025
Universitat de Barcelona
2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2025
Hospital Clínic de Barcelona
2025
Translational Research in Oncology
2023
Introduction Schizophrenia (SCZ) and autism spectrum disorder (ASD) are neurodevelopmental diseases characterized by different psychopathological manifestations divergent clinical trajectories. Various alterations at glutamatergic synapses have been reported in both disorders, including abnormal NMDA metabotropic receptor signaling. Methods We conducted a bicentric study to assess the blood serum levels of receptors-related amino acids their precursors, L-glutamate, L-glutamine, D-aspartate,...
Abstract Background The neurobiology underlying treatment-resistant schizophrenia (TRS) has not been fully elucidated1. This project provides a preliminary dissection of the neurobiological underpinnings cognitive dysfunction in (SCZ), such as disorganization factor, core clinical and pathophysiological correlate TRS2. In this context, TRS shows putative unique neuroimaging correlates compared to treatment-responsive (non-TRS)3, probably related specific functional disconnection patterns,...
Abstract Background Schizophrenia is a worldwide severe mental illness in which alterations at the synaptic level play an essential role underpinning neuropathology [1]. Impairments spines result ineffective data processing whole brain with detrimental effects on network measures Aberrant and integration of neuronal information could directly lead to onset psychotic symptoms by affecting functioning Central Executive, Salience, Default Mode Network [2]. Aims The present work aims explore...
Abstract Background Schizophrenia (SCZ) is a severe mental disorder characterized by positive, negative1, and cognitive symptoms2. The most forms of this include relevant formal thought disturbances, which are collectively referred to as the disorganization domain. Notably, recent study demonstrated that domain predictive diagnose treatment resistant subtype SCZ3. Formal disorders can be defined fragmentation logical process reconstructed skilled clinicians through different evaluation...
Abstract Background Stress is responsible for impacting brain regions’ synaptic changes and functional connectivity modifications that hesitate in several cognitive processes such as spatial declarative memory, fear, memories of emotionally charged events, executive functions fear extinction are all cross-functional the functioning neurodevelopmental disorders. Aims We investigated transcript Homer1a, an Immediate Early Gene, which encodes a crucial molecule dendritic spine involved...
Treatment-resistant schizophrenia (TRS) occurs when symptoms persist despite adequate antipsychotic treatment in terms of both timing and dosage. This severe condition is often overlooked, the existence guidelines, with an average delay 4-9 years before introduction clozapine, gold standard treatment. We hypothesized that patients autistic are more prone to develop TRS. To test this, we administered Positive Negative Syndrome Scale for Schizophrenia Autism Severity (PAUSS) 117 diagnosed...
Schizophrenia is a chronic and severe psychiatric disorder affecting approximately 1% of the global population, characterized by disrupted synaptic plasticity brain connectivity. While substantial evidence supports its classification as neurodevelopmental disorder, non-canonical neurodegenerative features have also been reported, with increasing attention given to astrocytic dysfunction. Overall, in this study, we explore role astrocytes structural functional link between neurodevelopment...
Few longitudinal studies have so far investigated the impact of sustained COVID-19 among people with pre-existing psychiatric disorders. We conducted a prospective study involving serious mental illness (n = 114) and healthy controls 41) to assess changes in Perceived Stress Scale, Generalized Anxiety Disorder Patient Health Questionnaire, Specific Psychotic Experiences Questionnaire scores 18 months after pandemic outset. Subjects underwent interviews health professional April 2020 at end...
Treatment-resistant schizophrenia (TRS) is a severe psychiatric disorder that associated with high level of psychotic symptoms and cognitive deficit as well poor functioning, an increased risk mortality for cardiometabolic diseases. Some studies suggest lifestyle, particularly diet, could represent factor obesity its metabolic complications in these patients.
Although antipsychotics’ mechanisms of action have been thoroughly investigated, they not fully elucidated at the network level. We tested hypothesis that acute pre-treatment with ketamine (KET) and administration asenapine (ASE) would modulate functional connectivity brain areas relevant to pathophysiology schizophrenia, based on transcript levels Homer1a, an immediate early gene encoding a key molecule dendritic spine. Sprague–Dawley rats (n = 20) were assigned KET (30 mg/kg) or vehicle...
Abstract The role of minimally invasive surgery in the treatment transverse colon cancer is still controversial. aim this study to investigate advantages a totally laparoscopic technique comparing open versus laparoscopic/robotic approach. Three hundred and eighty-eight patients with cancer, treated segmental resection, were retrospectively analyzed. Demographic data, tumor stage, operative time, intraoperative complications, number harvested lymph nodes recovery outcomes recorded....
Early life stress may induce synaptic changes within brain regions associated with behavioral disorders. Here, we investigated glutamatergic functional connectivity by a postsynaptic density immediate-early gene-based network analysis. Pregnant female Sprague-Dawley rats were randomly divided into two experimental groups: one exposed to sessions and the other serving as stress-free control group. Homer1 expression was evaluated in situ hybridization technique eighty-eight of interest male...