A5010709812- Chemotherapy-related skin toxicity
- Vascular Malformations and Hemangiomas
- Urologic and reproductive health conditions
- Colorectal and Anal Carcinomas
- Heat shock proteins research
- Hidradenitis Suppurativa and Treatments
- Vascular Tumors and Angiosarcomas
University of North Carolina at Chapel Hill
2024
University of North Carolina Health Care
2022
University of North Carolina at Charlotte
2018
Hsp70 is a well-conserved molecular chaperone involved in the folding, stabilization, and eventual degradation of many "client" proteins. regulated by suite co-chaperone molecules that assist Hsp70-client interaction stimulate intrinsic ATPase activity Hsp70. While previous studies have shown anticancer target ribonucleotide reductase (RNR) client Hsp70, regulatory co-chaperones remain to be determined. To identify co-chaperone(s) RNR activity, 28 yeast knockout mutants were screened for...
Cutaneous pyogenic granulomas (PGs) are common, benign vascular tumors of uncertain pathogenesis; however, a growing body literature suggests that the formation PGs may be secondary to genetic alterations in both Ras/Raf/MAPK and PI3K/Akt/mTOR pathways. We present three cases spontaneous multifocal first presented infancy, were not associated with other anomalies or discernable etiology, harbored somatic variants pathway (NRAS n = 2, FGFR1 1), refractory treatment beta-blockers mTOR...