A5050374513- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Pharmaceutical Practices and Patient Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Respiratory Support and Mechanisms
- Antibiotic Resistance in Bacteria
- Infections and bacterial resistance
- Inhalation and Respiratory Drug Delivery
- Sepsis Diagnosis and Treatment
- Innovations in Medical Education
- Medical Education and Admissions
- Intensive Care Unit Cognitive Disorders
- Bacterial biofilms and quorum sensing
- Acute Kidney Injury Research
- Antibiotic Use and Resistance
- Health Sciences Research and Education
- Anesthesia and Sedative Agents
- Heparin-Induced Thrombocytopenia and Thrombosis
- Vitamin D Research Studies
- Renal function and acid-base balance
- Healthcare Decision-Making and Restraints
- Cardiac, Anesthesia and Surgical Outcomes
- Clinical Reasoning and Diagnostic Skills
- Cardiac Arrest and Resuscitation
- Abdominal Surgery and Complications
University of Tennessee Health Science Center
2016-2025
Bartlett Public Library District
2025
University of Tennessee at Knoxville
2004-2023
Translational Sciences (United States)
2020-2022
Regional Medical Center
2020-2022
University of Arkansas for Medical Sciences
2017
Midwestern University
2017
Loyola University Medical Center
2017
Medical University of South Carolina
2017
Rush University Medical Center
2017
Introduction: The Clinical Pulmonary Infection Score (CPIS) has received much attention recently. Advocates have touted its use for the diagnosis and duration of therapy in patients with ventilator-associated pneumonia (VAP). However, little been written about utility trauma patients. clinical, physiologic, radiologic components CPIS may be difficult to differentiate from systemic effects injury. Quantitative cultures lower airway shown efficacious differentiating VAP inflammatory response...
Introduction: It is unclear why differences in patient location change organisms causing ventilator-associated pneumonia (VAP). We investigated VAP three geographically separate trauma intensive care units (TICUs).
In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon possible after acceptance. Accepted have been peer-reviewed and copyedited, but are posted before technical formatting author proofing. These not final version record will be replaced with article (formatted per style proofed by authors) at a later time. The intent this study was evaluate predictive performance two common methods for estimating kidney function in critically ill trauma patients...
Background: Our protocolized empiric antibiotic therapy for early (≤7 d) ventilator-associated pneumonia (VAP) and late (>7 VAP based on our local antibiogram leads to inappropriate (IEAT) approximately 15% of the time. We reviewed trauma intensive care unit (TICU) determine if sensitivity patterns were changing warranted protocol adjustments. hypothesized there would be no change in IEAT over Patients Methods: TICU patients with (bronchoalveolar lavage culture ≥100,000 CFU/mL) between 2017...
Background: Ventilator-associated pneumonia (VAP) is a frequent complication during recovery of severely traumatized patients. The primary objective this study was to determine if prophylactic administration aerosolized ceftazidime reduced the incidence VAP in high-risk injured patients without altering other infectious complications. Patients and Methods: This single-institution double-blind, randomized trial that compared seven-day course with placebo. Intubated admitted trauma intensive...
To determine clinical and microbiologic success in patients receiving adjunctive aerosolized antibiotics for the treatment of ventilator-associated pneumonia (VAP).Retrospective medical record review.Level I trauma intensive care unit a large academic center.Forty-nine (mean +/- SD age 42 19 yrs) who received total 60 episodes VAP caused by Pseudomonas aeruginosa and/or Acinetobacter baumannii between January 2001 July 2007.Patients were identified using an existing database with documented...
Abstract Introduction Limited data suggest mild hypernatremia may be related to lower intracranial pressure (ICP) in patients with traumatic brain injury (TBI). The practice at the study center has been use hypertonic saline (HTS) generate a targeted serum sodium of 145 155 mEq/l TBI. purpose this was determine relationship between values and ICP, evaluate acute effect HTS on ICP. Methods A retrospective review who were admitted trauma ICU for TBI, had an ICP monitor placed, received least...
<b>Objective.</b> To examine perceived motivating factors and barriers (MFB) to postgraduate training (PGT) pursuit among pharmacy students. <b>Methods.</b> Third-year students at 13 schools of provided demographics their plan MFBs for pursuing PGT. Responses were characterized using descriptive statistics. Kruskal-Wallis equality-of-proportions rank tests determined if differences in existed between based on pursue <b>Results.</b> Among 1218 (69.5%) respondents, 37.1% planned PGT (32.9% did...
Background: Using an arbitrary day cutoff or clinical signs to decide the duration of antibiotic therapy for ventilator-associated pneumonia (VAP) may be suboptimal some patients. We sought determine whether VAP can safely abbreviated in trauma patients using repeat bronchoalveolar lavage (BAL). Methods: This was observational case-controlled pilot study. Fifty-two were treated a BAL pathway. Definitive discontinued if pathogen growth <10,000 colony forming units/mL on performed 4...
Vitamin D depletion has been associated with increased rate of infections, lengthened hospital stay, and worsened mortality for critically ill patients. The purpose this study was to evaluate the prevalence variables vitamin deficiency in patients severe traumatic injuries.Critically adult admitted trauma intensive care unit (ICU) between June 2013 2014, referred nutrition support service enteral or parenteral nutrition, had a serum 25-hydroxyvitamin (25-OH D) concentration determination...
Study objective High-dose continuous venovenous hemofiltration (CVVH) is a renal replacement therapy (CRRT) used frequently in patients with burns. However, antibiotic dosing based on inference from studies assessing substantially different methods of CRRT. To address this knowledge gap for imipenem/cilastatin (I/C), we evaluated the systemic and extracorporeal clearances (CLs) I/C burns undergoing high-dose CVVH. Design Prospective clinical pharmacokinetic study. Patients Ten adult...
Objective. To characterize the practices and perceptions of recent post-graduate year 2 (PGY2) critical care pharmacy (CCP) residents surrounding completion publication their primary research project. Methods. Potential factors influencing project success were identified incorporated in a validated electronic survey distributed to 2011 2012 PGY2 CCP residency program graduates. Results. Among 94/124 (76%) respondents, 26% had published (67% first authors; 50% successful on submission), while...
The association among residency program and research mentor characteristics, director perceptions, the publication of primary project for postgraduate year 2 (PGY2) graduates was assessed.Using a validated electronic survey, directors (RPDs) critical care PGY2 were asked about success, RPDs' perceptions surrounding completion.All 55 RPDs surveyed responded; 44 (79%) reported being mentor. publications in 2011 2012 totaled 26 (37%) 27 (35%), respectively. A significant relationship existed...
Background: More than one half of lower respiratory cultures are negative for ventilator-associated pneumonia (VAP) and final reporting requires 72 hours to 96 hours. A previous retrospective study concluded that preliminary bronchoalveolar lavage (BAL) culture results (pBAL), reported at approximately 24 hours, accurately predicted BAL (fBAL). Our objective was verify the predictive value pBALs fBALs, evaluate use insignificant (1–99,999 cfu/mL) rapid discontinuation empirical antibiotics....
Empiric antibiotic therapy is routinely initiated for patients with presumed ventilator-associated pneumonia (VAP). Reported mortality rates inadequate empiric (IEAT) VAP range from 45 to 91 per cent. The purpose of this study was determine the effect a unit-specific pathway management on reducing IEAT episodes and improving outcomes in trauma patients. Patients admitted over 36-months were identified stratified by gender, age, severity shock, injury severity. Outcomes included number...
Abstract BACKGROUND: Intensive insulin protocols (IIPs) have been demonstrated to reduce morbidity and mortality in critically ill patients. Currently, there are no published studies evaluating glycemic control after discontinuation of an IIP. OBJECTIVE: The purpose this study was compare blood glucose (BG) during IIP for 5 days following its (follow‐up period). METHODS: a retrospective review intensive care unit patients who received ≥24 hours. Data were collected the last 12 hours...