A5062262974- Sepsis Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Anesthesia and Sedative Agents
- Nosocomial Infections in ICU
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Clinical Nutrition and Gastroenterology
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Acute Kidney Injury Research
- Electrolyte and hormonal disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Renal function and acid-base balance
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Pain Management
- Hemodynamic Monitoring and Therapy
- Poisoning and overdose treatments
- Abdominal Trauma and Injuries
- Chronic Kidney Disease and Diabetes
- Cholinesterase and Neurodegenerative Diseases
- Bacterial biofilms and quorum sensing
- Renal and Vascular Pathologies
- Rheumatoid Arthritis Research and Therapies
- Rabies epidemiology and control
University of Tennessee Health Science Center
2020-2025
Auburn University
2021-2022
University of Tennessee at Knoxville
2022
University of Cincinnati Medical Center
2020-2021
University of Cincinnati
2020-2021
Translational Sciences (United States)
2020
The Medical Center of Aurora
2020
Introduction: It is unclear why differences in patient location change organisms causing ventilator-associated pneumonia (VAP). We investigated VAP three geographically separate trauma intensive care units (TICUs).
In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon possible after acceptance. Accepted have been peer-reviewed and copyedited, but are posted before technical formatting author proofing. These not final version record will be replaced with article (formatted per style proofed by authors) at a later time. The intent this study was evaluate predictive performance two common methods for estimating kidney function in critically ill trauma patients...
Background: Our protocolized empiric antibiotic therapy for early (≤7 d) ventilator-associated pneumonia (VAP) and late (>7 VAP based on our local antibiogram leads to inappropriate (IEAT) approximately 15% of the time. We reviewed trauma intensive care unit (TICU) determine if sensitivity patterns were changing warranted protocol adjustments. hypothesized there would be no change in IEAT over Patients Methods: TICU patients with (bronchoalveolar lavage culture ≥100,000 CFU/mL) between 2017...
Patients with COVID-19 are at higher risk of thrombosis due to the inflammatory nature their disease. A higher-intensity approach pharmacologic thromboprophylaxis may be warranted. The objective this retrospective cohort study was determine if a patient specific, targeted-intensity protocol incorporating severity illness, weight, and biomarkers decreased incidence in hospitalized patients COVID-19. Included were received within 48 h admission. Exclusion criteria included receipt therapeutic...
The purpose of this study was to evaluate the efficacy and safety intragastric administration small volumes sodium enema solution containing phosphorus as replacement therapy in critically ill patients with traumatic injuries who required continuous enteral nutrition. Adult (>17 years age) had a serum concentration <3 mg/dL (0.97 mmol/L) were evaluated. Patients creatinine >1.4 (124 µmol/L) excluded. given 20 mL saline intragastrically, 34 mmol mixed 240 water. A total 55% 73% received one...
Midazolam (MZ) is commonly used in critically ill neurosurgical patients. Neuro-penetration of MZ and its metabolite, 1-hydroxy-midazolam (1-OH-MZ), not well characterized.
Abstract Background The purpose of this study was to determine whether successful outpatient management diabetes, as assessed by hemoglobin A1c (Hgb A1c), influences inpatient glycemic control. Methods Adult patients, aged >17 years, admitted the trauma intensive care unit, who received continuous nutrition therapy, and exhibited a blood glucose concentration (BG) > 149 mg/dl or 8.3 mmol/L were retrospectively evaluated. Controlled diabetes mellitus (DM‐C) defined history DM Hgb <...
What is known and objective Stenotrophomonas maltophilia an intrinsically multidrug-resistant (MDR) organism which commonly presents as a respiratory tract infection. S. typically treated with high-dose sulfamethoxazole/trimethoprim (SMX/TMP). However, SMX/TMP other treatment options for can be limited because of resistance, allergy, adverse events or unavailability the drug; use novel agents may necessary to adequately treat this MDR infection overcome these limitations. Case description...
Deichstetter, Kaley; Farrar, Julie; Philpott, Carolyn; Droege, Christopher; Ernst, Neil; Mueller, Eric; Katampe, Stephanie; O'Toole, Erin; Roell, Claire; Makley, Amy; Sagi, Henry; Molly Author Information
Introduction: Quetiapine is frequently used in the Intensive Care Unit (ICU) for delirium treatment and adjunctively patients with IV sedation requirements. Traumatic brain injury (TBI) are typically excluded descriptions of quetiapine use. This study evaluated our institution's experience de-escalation after initiation. We sought to compare characteristics outcomes who did not require 72 hours Additionally, we use without TBI. Methods: included admitted a trauma ICU required mechanical...
Introduction: Three geographically separate intensive care units (ICU) containing patients admitted to the same trauma service will have similar incidences of multidrug resistant (MDR) organisms causing ventilator associated pneumonia (VAP) within first seven days admission. Methods: Patients ≥ 18 years old, a ICU (TICU) with multidisciplinary teams and treatment pathways, confirmed VAP (bronchoalveolar lavage [BAL] performed ≤7 after admission growing ≥105 colony forming units) were...
Introduction: The goal of this study was to evaluate the accuracy and predictive ability two scoring tools identify augmented renal clearance (ARC) in critically ill trauma patients. Methods: Patients ≥18 years age, admitted intensive care unit (TICU), referred Nutrition Support Service, undergoing 24-hour urine collection for nitrogen balance (NBAL) measured creatinine (mCrCl) calculation were eligible inclusion. divided into groups by presence or absence ARC (mCrCl ≥130 mL/min/1.73m2)....
Introduction: The penetration of midazolam into the CNS is unknown. We hypothesized that CSF concentrations and 1-hydroxy-midazolam were not correlated to serum or dosages. Methods: Prospective study adults in neurosurgical ICU with an EVD receiving by continuous infusion. Serum samples obtained 12-24 hours 72-96 after infusion initiation determined duplicate high-performance liquid chromatography tandem mass spectrometry. Bivariate correlation analyses used Pearson coefficient. Results:...
Introduction: Reduction in hyperglycemia has been associated with improved clinical outcomes for critically ill patients. Neutral Protamine Hagedorn (NPH) insulin successfully used glycemic control hyperglycemic patients who required enteral nutrition. However, NPH causes peak and nadir concentrations. The purpose of this study is to assess compare received every 12 hours versus 8 hours. Methods: This retrospective case series was conducted at a level 1 regional trauma center. Patients > 18...
Dieldrin is quantitatively extracted from wool with benzene–methanol, separated the extract chromatographically, and reacted diphenylamine zinc chloride to give a blue colour, optical density of which measured.