A5027938879- Sarcoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Vascular Tumors and Angiosarcomas
- Neuroblastoma Research and Treatments
- Bone health and treatments
- Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cutaneous lymphoproliferative disorders research
- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cardiac tumors and thrombi
- Cancer Cells and Metastasis
- Medical Imaging and Pathology Studies
- Bone Tumor Diagnosis and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Contact Dermatitis and Allergies
- Cancer-related molecular mechanisms research
- Gastrointestinal Tumor Research and Treatment
- RNA Research and Splicing
- Genetic and rare skin diseases.
- Bone and Joint Diseases
- Pituitary Gland Disorders and Treatments
- Mast cells and histamine
- Radiomics and Machine Learning in Medical Imaging
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Istituto Giannina Gaslini
2016-2021
University of Ferrara
2018
University of Genoa
2008-2016
Ospedale Policlinico San Martino
2016
Università Campus Bio-Medico
2015
Giant cell tumor of bone (GCTB) and desmoplastic fibroma (DF) are sarcomas with intermediate malignant behavior unpredictable prognosis. These locally aggressive neoplasms exhibit a predilection for the long or mandible young adults, causing severe resorption. In particular, stromal cells these lesions responsible recruiting multinucleated giant which ultimately lead to disruption. this regard, underlying pathological mechanism osteoclastogenesis processes in GCTB DF is still poorly...
A second-line standard of treatment has not yet been identified in patients with soft tissue sarcomas (STS), so identifying predictive markers could be a valuable tool. Recent studies have shown that the intratumoral and inflammatory systems significantly influence tumor aggressiveness. We aimed to investigate prognostic values pre-therapy neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR), systemic index (SII), progression-free survival (PFS),...
Abstract Background Soft tissue sarcomas (STS) are a rare group of solid neoplasm including among others liposarcoma, leiomyosarcoma (L-sarcoma) and undifferentiated pleomorphic sarcoma (UPS) entities. The current first-line treatment is represented by anthracycline based- regimens, second-line may include trabectedin. Currently the activity trabectedin its mechanism action not completely elucidated. Methods Taking advantages our 3D patient-derived primary culture translational model we...
NTRK (neurotrophic tyrosine receptor kinase)-rearranged spindle cell neoplasms are a new group of tumors included in the 5th edition World Health Organization (WHO) classification soft Tissue and Bone Sarcomas. These characterized by gene fusions show wide spectrum histologies clinical behavior. Several targeted therapies have recently been approved for harboring fusions, including STS.A 26-year-old male with advanced, pretreated rearranged neoplasm liver, lung bone metastases was treated...
Myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) can be considered as a spectrum of the same disease entity, representing one most common adult soft tissue (STS) extremities. While MFS is rarely metastasizing, it shows an extremely high rate multiple frequent local recurrences (50–60% cases). On other hand, UPS aggressive prone to distant recurrence, which correlated poor prognosis. Differential diagnosis challenging due their heterogeneous morphology, with remaining...
Osteosarcoma (OS) is the most common primary malignant tumor of bone. Due to its high heterogeneity and survival signals from bone microenvironment, OS can resist standard treatments, therefore novel therapies are needed. c-MET oncogene, a tyrosine-kinase receptor, plays crucial role in initiation progression. The present study aimed evaluate effect inhibitor cabozantinib (CBZ) on both directly through action microenvironment. We tested different doses CBZ vitro models alone or co-culture...
Objective: Squamous cell carcinoma (SCC) represents the most common histotype of all head and neck malignancies includesoropharyngeal squamous (OSCC), a tumor associated with different clinical outcomes linked to human papillomavirus (HPV) status. Translational research has few available in vitro models which study pathophysiologicalbehavior OSCCs. The present proposes 3-dimensional (3D) biomimetic collagen-based scaffold mimic tumormicroenvironment crosstalk between extracellular matrix...
Bone metastases (BMs) are a negative prognostic factor in patients with non-small cell lung cancer (NSCLC). Although immune-checkpoint inhibitors (ICIs) have dramatically changed the therapeutic landscape of NSCLC, little information is available on BMs from NSCLC treated ICIs alone or association bone-targeted therapy (BTT) such as zoledronate denosumab.From 2014 to 2020, 111 142 secondary extrapolated prospective multicenter Italian BM Database were eligible for analysis. Information blood...
Immunotherapy has emerged as promising treatment in sarcomas, but the high variability terms of histology, clinical behavior and response to treatments determines a particular challenge for its role these neoplasms. Tumor immune microenvironment (TiME) sarcomas reflects heterogeneity tumors originating from mesenchymal cells encompassing more than 100 histologies. Advances understanding complexity TiME have led an improvement immunotherapeutic responsiveness that at first showed...
Background Glioblastoma (GBM) is a poor prognosis grade 4 glioma. After surgical resection, the standard therapy consists of concurrent radiotherapy (RT) and temozolomide (TMZ) followed by TMZ alone. Our previous data on melanoma patients showed that Dendritic Cell vaccination (DCvax) could increase amount intratumoral-activated cytotoxic T lymphocytes Methods This single-arm, monocentric, phase II trial in two steps according to Simon’s design. The aims evaluate progression-free survival...
Objectives: The aim of this study was to investigate the treatment patterns and outcomes in two propensity score-matched cohorts patients with neuroendocrine tumours (NETs) treated first-line somatostatin analogue (SSA). Methods: Metastatic NET SSA (2009-2022) were retrospectively examined. First-line lanreotide vs. octreotide matched 1:1 by scores for demographics, tumour characteristics, diagnosis year. Progression-free survival (PFS) overall (OS) analysed using Kaplan-Meier analysis Cox...
Undifferentiated pleomorphic sarcoma (UPS) is an aggressive mesenchymal neoplasm with no specific line of differentiation. Eribulin, a novel synthetic microtubule inhibitor, has shown anticancer activity in several tumors, including soft tissue sarcomas (STS). We investigated the molecular biology UPS, and mechanisms action this innovative microtubule-depolymerizing drug. A primary culture from patient UPS was established characterized terms gene expression. The eribulin also compared that...
Neuroendocrine neoplasias (NENs) are a rare group of tumors with different prognosis and response to therapy. Their heterogeneity is dependent on the site origin, morphology, Ki67. Temozolomide (TEM) appears be active in metastatic NENs (mNENs) but there limited evidence about its efficacy gastrointestinal NENs. We analyzed "real-world" data use TEM alone or association capecitabine (CAPTEM) patients mNENs.One hundred consecutive advanced treated CAPTEM between 2009 2019 were included. A...
Adult rhabdomyosarcoma (RMS) represents an uncommon entity with incidence of less than 3% all soft tissue sarcomas (STS). Consequently, the natural history and clinical management this disease are infrequently reported. In order to fill gap, we investigated molecular biology adult RMS case series. The expression epithelial mesenchymal transition-related gene chemoresistance-related panels were evaluated. Moreover, taking advantage our STS translational model combining patient-derived primary...