A5019322829- Sarcoma Diagnosis and Treatment
- Bone health and treatments
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Cancer Cells and Metastasis
- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Oral and Maxillofacial Pathology
- Cancer Immunotherapy and Biomarkers
- Bone Metabolism and Diseases
- Soft tissue tumor case studies
- Tracheal and airway disorders
- Gastrointestinal Tumor Research and Treatment
- Cancer Research and Treatments
- Cancer Risks and Factors
- Head and Neck Surgical Oncology
- Bone health and osteoporosis research
- Tumors and Oncological Cases
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2014-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2024
Istituto Oncologico Romagnolo
2005-2006
Ospedale G.B. Morgagni - L.Pierantoni
2005
A second-line standard of treatment has not yet been identified in patients with soft tissue sarcomas (STS), so identifying predictive markers could be a valuable tool. Recent studies have shown that the intratumoral and inflammatory systems significantly influence tumor aggressiveness. We aimed to investigate prognostic values pre-therapy neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR), systemic index (SII), progression-free survival (PFS),...
Abstract Background Soft tissue sarcomas (STS) are a rare group of solid neoplasm including among others liposarcoma, leiomyosarcoma (L-sarcoma) and undifferentiated pleomorphic sarcoma (UPS) entities. The current first-line treatment is represented by anthracycline based- regimens, second-line may include trabectedin. Currently the activity trabectedin its mechanism action not completely elucidated. Methods Taking advantages our 3D patient-derived primary culture translational model we...
Objective: Squamous cell carcinoma (SCC) represents the most common histotype of all head and neck malignancies includesoropharyngeal squamous (OSCC), a tumor associated with different clinical outcomes linked to human papillomavirus (HPV) status. Translational research has few available in vitro models which study pathophysiologicalbehavior OSCCs. The present proposes 3-dimensional (3D) biomimetic collagen-based scaffold mimic tumormicroenvironment crosstalk between extracellular matrix...
Background Glioblastoma (GBM) is a poor prognosis grade 4 glioma. After surgical resection, the standard therapy consists of concurrent radiotherapy (RT) and temozolomide (TMZ) followed by TMZ alone. Our previous data on melanoma patients showed that Dendritic Cell vaccination (DCvax) could increase amount intratumoral-activated cytotoxic T lymphocytes Methods This single-arm, monocentric, phase II trial in two steps according to Simon’s design. The aims evaluate progression-free survival...
Neuroendocrine neoplasias (NENs) are a rare group of tumors with different prognosis and response to therapy. Their heterogeneity is dependent on the site origin, morphology, Ki67. Temozolomide (TEM) appears be active in metastatic NENs (mNENs) but there limited evidence about its efficacy gastrointestinal NENs. We analyzed "real-world" data use TEM alone or association capecitabine (CAPTEM) patients mNENs.One hundred consecutive advanced treated CAPTEM between 2009 2019 were included. A...
Adult rhabdomyosarcoma (RMS) represents an uncommon entity with incidence of less than 3% all soft tissue sarcomas (STS). Consequently, the natural history and clinical management this disease are infrequently reported. In order to fill gap, we investigated molecular biology adult RMS case series. The expression epithelial mesenchymal transition-related gene chemoresistance-related panels were evaluated. Moreover, taking advantage our STS translational model combining patient-derived primary...
Trans-oral robotic surgery (TORS) has changed surgical management of patients with oropharyngeal squamous cell carcinomas (OPSCC). In this study we present and oncologic outcomes carcinomas, treated using TORS, without an adjuvant therapy. Sixty TORS between January 2008 December 2017 have been retrospectively evaluated considering clinicopathologic features, disease characteristics, treatments oncological outcomes. was performed for OPSCC to the base tongue in 41.7%, tonsils 46.7%, soft...
Background: We present a retrospective analysis of metronomic capecitabine in metastatic gastroenteropancreatic neuroendrocrine tumors (GEP-NETs). A review the literature is also presented. Methods: From January 2007 to December 2013, ten patients with GEP-NETs (four pancreatic and six ileal) who progressed after treatment somatostatin analogs other cytotoxic agents received oral 1,500 mg/day continuously. The median patient age was 68 (range 29–82) years. duration 8 months. Results: Five...
Gastrointestinal stromal tumors are rare malignancies characterized by c-kit and PDGFR-α mutations targeted imatinib. Pleural effusion is a very side effect of imatinib treatment. A 65-year-old female with metastatic gastrointestinal tumor developed electrolyte imbalance, severe peripheral edema progressively worsening dyspnea 2 months after starting Having excluded cardiovascular pulmonary disorders, was discontinued prednisone 25 mg orally daily begun. The patient's condition improved...
Malignant tumors of the lacrimal gland are rare, and single bone metastases from carcinoma an exceptional event. We present case a 71-year-old man with history lumbar pain left exophthalmos. Surgical resection lesion biopsy gave final histopathological diagnosis primary ductal adenocarcinoma metastasis. The pathological tissue both procedures was positive for androgen receptor expression. patient underwent embolization radiotherapy in association total blockade. After 20 months, is still...
We assessed the real-life clinical impact of bone health management in patients with breast cancer (BC) receiving adjuvant endocrine therapy at an Italian Osteoncology Center.Pre- and post-menopausal women undergoing for early-stage BC who came to our institute their first evaluation from January 2011 June 2016 were considered this retrospective observational study.1125 pre- (209 916, respectively) evaluated. Median age was 61 years (range 26-88). In pre-menopausal group, spinal x-ray...
We present the first documented case of hemangioblastoma located in left colon. A 75-year-old woman undergoing adjuvant chemotherapy for breast cancer experienced rectal bleeding. Colonoscopy revealed a roundish mass covered with normal mucosa sigmoid Endoscopic ultrasound showed an isoechoic lesion originating from third layer intestinal wall; underlying layers were normal. features not suggestive either or malignant stromal tumor. Left hemicolectomy was subsequently performed due to...
3603 Background: KRAS mutations negatively affect outcome after cetuximab (CTX) in metastatic colorectal cancer (mCRC). As only 20% of wild-type (WT) patients respond it is possible that other mutations, constitutively activating the EGFR pathway, are present non-responding WT. We retrospectively correlated KRAS, BRAF and PI3K mutational status with clinical 64 mCRC treated CTX plus chemotherapy. Methods: DNA was extracted from 5 mM paraffin-embedded sections containing at least 50% tumoral...
The study aims to evaluate the predictive factors of disease relapse in patients with soft tissue sarcoma, focusing on systemic and intratumoral immune status molecular features, guide optimal therapeutic planning prevent affected by WDL, DDL, MFS, UPS. involved localized or UPS who underwent surgery from 2010 2020. FFPE samples surgical specimen were collected 71 perform an RNAseq, among these 47 more than 4M reeds selected a CIBERSORT analysis assess tumour-infiltrating cells. A...