A5084203692- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Bioactive Compounds and Antitumor Agents
- Electrospun Nanofibers in Biomedical Applications
- Dental materials and restorations
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Cancer therapeutics and mechanisms
- Proteoglycans and glycosaminoglycans research
- Organic Chemistry Cycloaddition Reactions
- Fungal and yeast genetics research
- Curcumin's Biomedical Applications
- Wound Healing and Treatments
- Corneal Surgery and Treatments
- Retinoids in leukemia and cellular processes
- Synthesis and biological activity
- Cell Adhesion Molecules Research
- Histone Deacetylase Inhibitors Research
- Herpesvirus Infections and Treatments
- Cancer Cells and Metastasis
- Ocular Surface and Contact Lens
- Acute Myeloid Leukemia Research
Vilnius University
2015-2024
Curcumin, a natural polyphenolic substance, has been known for more than two millennia as having strong anti-inflammatory activity towards multiple ailments, including arthritis. The main drawback of curcumin is its poor solubility in water, which leads to low intestinal absorption and minimal bioavailability. In this study, we aimed compare the anti-arthritic vivo effect different preparations - basic extract, micellar curcumin, mixture with piperine, microencapsulated curcumin.Arthritis...
Abstract Pathophysiologic inflammation, e.g., from HSV-1 viral infection, can cause tissue destruction resulting in ulceration, perforation, and ultimately blindness. We developed an injectable Cornea-in-a-Syringe (CIS) sealant-filler to treat damaged corneas. CIS comprises linear carboxylated polymers of inflammation-suppressing 2-methacryloyloxyethyl phosphorylcholine, regeneration-promoting collagen-like peptide, adhesive collagen-citrate glue. also incorporated GF19, a modified...
The demand for bone grafting procedures in various fields of medicine is increasing. Existing substitutes clinical practice do not meet all the criteria required an ideal scaffold, so new materials are being sought. This study evaluated regeneration using a critical-size Wistar rat’s calvarial defect model. 12 male and female rats were evenly divided into 3 groups: 1. Negative positive (Geistlich Bio-Oss®) controls; 2. polylactic acid (PLA) PLA/hydroxyapatite (HA); 3. PLA/HA cellularised...
Abstract Topography of the scaffold is one most important factors defining quality artificial bone. However, production precise micro‐ and nano‐structured scaffolds, which known to enhance osteogenic differentiation, expensive time‐consuming. Meanwhile, little about macro‐patterns (larger than cell diameter) effect on fate, while this kind structures would significantly facilitate manufacturing skeleton. Therefore, research focused polylactic acid scaffold's macro‐pattern impact rat's dental...
The mesenchymal stem cell (MSC) secretome has been considered an innovative therapeutic biological approach, able to modulate cellular crosstalk and functionality for enhanced tissue repair regeneration. This study aims evaluate the of isolated from periosteum-derived MSCs, either basal or osteogenic-induced conditions, in healing a critical size calvarial bone defect rabbit model. A bioceramic xenograft was used as vehicle delivery, response established biocomposite system assessed by...
This study aimed to create novel bioceramic coatings on a titanium alloy and evaluate their surface properties in comparison with conventional prosthetic materials. The highly polished Ti6Al4V (Ti) was used as substrate for yttria-stabilized zirconium oxide (3YSZ) lithium disilicate (LS2) coatings. They were generated using sol-gel strategies. In comparison, surfaces of Ti, (ZrO2), polyether ether ketone (PEEK) composite, poly(methyl methacrylate) (PMMA) utilized. Novel characterized by an...
UV photofunctionalization of Zirconia-based materials for abutment fabrication is a promising approach that might influence the formation sound peri-implant seal, thus promoting long-term soft and hard tissue implant integration. This study aimed to evaluate effect treatment test specimens made by two different ZnO2-based ceramic on hydrophilicity, cell cytotoxicity, proliferation human gingival fibroblasts (HGFs). Two materials, high-translucent ultra-translucent multi-layered Zirconia...
Millions of people worldwide are affected by diseases or injuries which lead to bone/tooth loss and defects. While such clinical situations daily practice in most the hospitals, widely used treatment methods still have disadvantages. Therefore, this field medicine is actively searching new tissue regeneration techniques, one could be stem cell secretome. Thus, purpose research study was perform detail proteomic analysis periosteum-derived mesenchymal cells secretome order evaluate if it...
Myocarditis (MC) is an inflammatory disease of the myocardium that can cause sudden death in acute phase, and dilated cardiomyopathy (DCM) with chronic heart failure as its major long-term outcome. However, molecular mechanisms beyond MC phase remain poorly understood. The ankyrin repeat domain 1 (ANKRD1) a functionally pleiotropic stress/stretch-inducible protein, which modulate cardiac stress response during various forms pathological stimuli; however, involvement post-MC remodeling...
Resistance to the chemotherapeutic agents in clinical management of cancer remains a significant challenge, and mechanical environment cells is one major determinants this. Stiffening usually associated with increased chemoresistance cells, although this process depends on type cancer. Breast most frequently diagnosed cancer, more than half million people die from it each year worldwide. In study, we used frequent (70% cases) breast phenotype, representing MCF-7 cell line, investigate...
To enhance the treatment of patients' urethral defects, such as strictures and hypospadias, we investigated potential using artificial tissue. Our study aimed to generate this tissue assess its effectiveness in a rabbit model. Two types bioprinted grafts, based on methacrylated gelatin-silk fibroin (GelMA-SF) hydrogels, were produced: acellular, well loaded with autologous stem cells. Rabbit adipose cells (RASC) differentiated toward smooth muscle GelMA-SF hydrogel, while buccal mucosa...
A number of quinones have been shown to be efficient anticancer agents. However, some mechanisms their action, in particular cell signaling are not well understood. The aim this study was partly fill gap by characterizing the mode cytotoxicity 2,5-diaziridinyl-3,6-dimethyl-1,4-benzoquinone (MeDZQ) malignant mouse hepatoma cells (MH-22A) with regard expression and activation main molecules MAPK pathway. revealed unequal roles MAP kinases MeDZQ-induced death: compound did induce significant...
Nitrogen-based tetracyclic ortho-quinones (naphtho[1'2':4.5]imidazo[1,2-a]pyridine-5,6-diones, NPDOs) and their nitro-substituted derivatives (nitro-(P)NPDOs) were obtained by condensation of substituted 2,3-dichloro-1,4-naphthoquinones with 2-amino-pyridine -pyrimidine nitration at an elevated temperature. The structural features the compounds as well global regional electrophilic potency characterized means DFT computation. highly reactive substrates single- two-electron (hydride) -...
Background More than 2 million bone transplant procedures are carried out each year, making the second most commonly transplanted tissue in world. 3D structured and individually fabricated scaffolds promising treatment strategy, which would allow to shorten time lower extent of surgery. Cell-laid mineralised extracellular matrix (ECM) was shown be potential for improving cellular responses drive osteogenesis stem cells. Aim/Hypothesis printed PLA HAP their decellularized have a used as graft...
Background Soft tissue around implant abutment serves as a barrier that protects underlaying bone from various hazardous agents. In case of two-piece level dental implant, soft sealing is formed implant-abutment connection. Different materials and their surface modifications have shown to bear different biocompatibility properties. At present there growing amount prosthetic on market including new generation polymers 3D printed materials. Aim/Hypothesis The aim this study was compare the...
Background: Due to limited skeleton self-healing, bone grafts are used for defect repair. Although autografts considered be the gold standard, they have several disadvantages like supply, donor site morbidity. Therefore, one of most advanced alternatives could personalized 3D printed scaffolds. The stem cells or their extracellular matrix (ECM) seeded on scaffolds before implantation will induce angiogenesis and osteogenic differentiation. Aim/Hypothesis: This study aimed evaluate PLA...
Background: Characteristics of prosthetic materials have a huge effect on soft tissue integration around dental implants. It is proven that shape, design, and the microtopography surface an impact peri-implant response. However, it noted contamination material might negative cell growth. Therefore various cleaning protocols been suggested to improve biocompatibility proliferation. Aim/Hypothesis: The aim study was compare two different methods human gingival fibroblast (HGF) proliferation so...
Background: One of the most effective ways treating tooth loss is by using dental implants. Considering bone deficiencies, almost every second implant surgery needs grafting. Attempts are made to create personalized composite 3D printed scaffolds, which exhibit superior therapeutic results than traditional grafts. These scaffolds may be modified with extracellular matrix (ECM) for better osteoinductivity. Aim/Hypothesis: This study aimed evaluate effect in vivo polylactic acid (PLA) and...