A5010629010- Traumatic Brain Injury Research
- Functional Brain Connectivity Studies
- Biomedical and Chemical Research
- Infectious Encephalopathies and Encephalitis
- Neurogenetic and Muscular Disorders Research
- Psychosomatic Disorders and Their Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Neurobiology of Language and Bilingualism
- Cardiac Arrest and Resuscitation
- Amyotrophic Lateral Sclerosis Research
- Congenital Anomalies and Fetal Surgery
- Mechanical Circulatory Support Devices
- Neuroscience and Music Perception
- Music Therapy and Health
- Autoimmune Neurological Disorders and Treatments
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- RNA modifications and cancer
- Peripheral Neuropathies and Disorders
- Cardiac Structural Anomalies and Repair
- Epilepsy research and treatment
- Long-Term Effects of COVID-19
- EEG and Brain-Computer Interfaces
Sorbonne Université
2020-2024
Institut du Cerveau
2020-2024
Centre National de la Recherche Scientifique
2012-2024
Pitié-Salpêtrière Hospital
2020-2024
Assistance Publique – Hôpitaux de Paris
2020-2024
Inserm
2015-2024
Handicap moteur et cognitif et réadaptation
2021
Université Paris Cité
2012-2015
Délégation Paris 5
2012-2015
Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by the selective loss of spinal motor neurons due to depletion survival neuron (SMN) protein. No therapy currently available for SMA, which represents leading genetic cause death in childhood. In present study, we report that insulin-like growth factor-1 receptor (<i>Igf-1r</i>) gene expression enhanced cords SMA-like mice. The reduction expression, either at physiological (through physical exercise) or level, resulted...
Abstract Neurological examination of non-communicating patients relies on a few decisive items that enable the crucial distinction between vegetative state (VS)—also coined unresponsive wakefulness syndrome (UWS)—and minimally conscious state. Over past 10 years, this has proven its diagnostic value as well important prognostic consciousness recovery. However, clinicians are currently limited by three factors: (i) current behavioural repertoire is and restricted to cognitive domains in...
Predicting the functional recovery of patients with severe neurological condition due to coronavirus disease 2019 (COVID-19) is a challenging task. Only limited outcome data are available, pathophysiology poorly understood, and time-course still largely unknown. Here, we report case patient COVID-19 associated encephalitis presenting as prolonged state unresponsiveness for two months, who finally fully recovered consciousness, communication, autonomy after immunotherapy. In multimodal...
Key points The present study provides evidence that the cardiomyopathy observed in spinal muscular atrophy (SMA) model mice is mainly due to intrinsic cardiac alteration but not autonomic impairment. We demonstrated a non‐pathological sympathetic activity on heart of type 2 SMA‐like mice, which likely counteracts dramatic function, such as arrhythmia and reduced rate. for first time physical exercise partially restores conduction efficiency, prevents fibrosis, attenuates defects protein...
Pupil dilation response (PDR) has been proposed as a physiological marker of conscious access to stimulus or its attributes, such novelty. In previous study on healthy volunteers, we adapted the auditory "local global" paradigm and showed that violations global regularity elicited PDR. Notably without instructions, this effect was present only in participants who could consciously report regularities. study, used similar approach 24 non-communicating patients affected with Disorder...
Probing cognition and consciousness in the absence of functional communication remains an extremely challenging task. In this perspective, we imagined a basic clinical procedure to explore pain anticipation at bedside. series 61 patients with disorder consciousness, tested existence nociceptive response by pairing somaesthetic stimulation noxious stimulation. We then explored how correlated (i) status inferred from Coma Recovery Scale-Revised scoring, (ii) EEG signature stimulus...
This study aimed at probing covert language processing in patients with disorders of consciousness. An auditory paradigm contrasting words to pronounceable pseudowords was designed, while recording bedside electroencephalogram and computing the two main correlates lexicality: N400 late positive component (LPC). Healthy volunteers 19 patients, 10 a minimally conscious state 9 vegetative (also coined unresponsive wakefulness syndrome), were recorded. present all groups, whereas LPC only...
Stroke-induced aphasia is a leading cause of cognitive disability. The healthy right hemisphere may play role in compensation. Music-based therapy, known to enhance functions after stroke, offers potential intervention due its impact on brain connectivity, engaging both hemispheres. In this proof-of-concept study, we aimed assess the feasibility and effectiveness music-assisted therapy for language disorders following left strokes. We also sought preliminary insights into music post-stroke...