A5083837140- Neurobiology and Insect Physiology Research
- Autophagy in Disease and Therapy
- RNA Research and Splicing
- Plant Molecular Biology Research
- Neurogenetic and Muscular Disorders Research
- Animal Behavior and Reproduction
- Physiological and biochemical adaptations
- Protein Degradation and Inhibitors
- Photosynthetic Processes and Mechanisms
- Cellular transport and secretion
- Amyotrophic Lateral Sclerosis Research
- Genetics, Aging, and Longevity in Model Organisms
Rockefeller University
2024
The University of Queensland
2017-2024
How the brain makes trillions of synaptic connections using a genome only 20,000 genes is major question in modern neuroscience. Alternative splicing one mechanism that can increase number proteins produced by each gene, but its role regulating synapse formation poorly understood. In Drosophila, photoreceptors form with multiple postsynaptic elements including lamina neurons L1 and L2. L2 express distinct isoforms homophilic repulsive protein Dscam2, since these cannot bind to other,...
Dscam2 is a cell surface protein required for neuronal development in Drosophila; it can promote neural wiring through homophilic recognition that leads to either adhesion or repulsion between neurites. Here, we report also plays post-developmental role suppressing synaptic strength. This function dependent on one of two distinct extracellular isoforms the and autonomous motor neurons. We link PI3K enhancer, Centaurin gamma 1A, Dscam2-dependent regulation strength show changes...
Recent studies capitalizing on the newly complete nanometer-resolution Drosophila larval connectome have made significant advances in identifying structural basis of motor patterning. However, molecular mechanisms utilized by neurons to wire these circuits remain poorly understood. In this study we explore how cell-specific expression two Dscam2 isoforms, which mediate isoform-specific homophilic binding, contributes patterning and output larvae. Ablating isoform diversity resulted impaired...
Abstract Genome-wide association studies (GWAS) have identified numerous candidate ALS risk variants, but their cellular functions are often unknown. Recent a variant of GGNBP2 that results in increased expression. To better understand how this gene might contribute to disease, we investigated the function Drosophila Ggnbp2 (dGgnbp2) motor neurons. Loss showed dGgnbp2 is required for neuron synaptic development. A human transgene completely rescued these phenotypes indicating functionally...