A5012136369- Liver Disease Diagnosis and Treatment
- Ultrasound in Clinical Applications
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Amoebic Infections and Treatments
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Abdominal Trauma and Injuries
- Appendicitis Diagnosis and Management
- Radiation Dose and Imaging
- Lipid metabolism and disorders
- Congenital Anomalies and Fetal Surgery
- Lung Cancer Diagnosis and Treatment
- Parasitic infections in humans and animals
- Ultrasound Imaging and Elastography
- Ultrasound and Hyperthermia Applications
- Renal cell carcinoma treatment
- Advanced MRI Techniques and Applications
- Immune Response and Inflammation
- Radiology practices and education
- MRI in cancer diagnosis
- Cytokine Signaling Pathways and Interactions
University Hospital Leipzig
2016-2024
Leipzig University
2019-2024
University Hospital in Halle
2023-2024
International University of Health and Welfare
2024
Assistance Publique – Hôpitaux de Paris
2024
Memorial Hospital
2024
Tokyo Medical University
2024
Rocky Vista University
2024
National University
2024
Hôpital Beaujon
2024
Abstract Pyogenic liver abscesses (PLA) are life-threatening disorders and require immediate treatment, but structured evidence is sparse treatment guidelines not established. In a retrospective observational study of 221 adult PLA patients (mean age 63 years, 63% men) treated between 2013 2019 at the Leipzig University Medical Center, we characterized pathogen spectrum, clinical management outcomes. Biliary malignancies (33%), cholelithiasis (23%) ischemic biliary tract disease (16%) were...
Background Attenuation coefficient (AC) and shear-wave speed (SWS) are established US markers for assessing patients with metabolic dysfunction-associated steatotic liver disease (MASLD), while dispersion slope (DS) is not. Purpose To assess the relationship between multiparametric imaging DS, AC, SWS histopathologic necroinflammation in MASLD. Materials Methods This international multicenter prospective study enrolled consecutive biopsy-proven MASLD June 2019 March 2023. Before biopsy, all...
This study evaluated the impact of obesity on abdominal ultrasound diagnostics and assessed effect high-performance probes increased imaging quality. Lean obese subjects (n = 40; 58% female) were categorized according to body mass index (BMI, 21 48 kg/m2). A highly standardized examination abdomen was performed by trained examiners using three different in randomized order (standard probe versus two probes). Quality B-mode duplex a custom scoring approach for depiction liver kidney anatomy...
Purpose Ultrasound-guided biopsy of focal liver lesions (FLL) is a well-established procedure with crucial impact on therapeutic decisions. The safety and accuracy depend needle type, tumour location comorbidities. Modern oncological concepts often require large specimens which may increase the procedural risk. Materials methods We retrospectively collected data from consecutively scheduled ultrasound-guided FLL biopsies performed in an interdisciplinary ultrasound unit at university...
Abstract Patients with type 2 diabetes (T2D) are at risk for non-alcoholic fatty liver disease (NAFLD) and associated complications. This study evaluated the performance of international (EASL-EASD-EASO) national (DGVS) guidelines NAFLD stratification. T2D prospectively underwent ultrasound, stiffness measurement (LSM) serum-based fibrosis markers. Guideline-based classification referral rates different screening approaches were compared diagnostic properties simplified algorithms, genetic...
Abstract Purpose Ultrasound (US) represents the primary approach for abdominal diagnosis and is regularly used to guide diagnostic therapeutic interventions (INVUS). Due possible serious INVUS complications, structured training concepts are required. Phantoms can facilitate teaching, but their use currently restricted by complex manufacturing short durability of materials. Hence, aim this study was development evaluation an optimized phantom. Materials Methods Phantom requirements were...
Abstract Background and Aims Steatotic liver disease (SLD) is generally considered to represent a hepatic manifestation of metabolic syndrome includes spectrum comprising isolated steatosis, dysfunction‐associated steatohepatitis, fibrosis ultimately cirrhosis. A better understanding the detailed underlying pathogenic mechanisms this transition crucial for design new efficient therapeutic interventions. Thymocyte differentiation antigen (Thy‐1, also known as CD90) expression on fibroblasts...
Fatty liver diseases (FLD), especially defined as metabolic dysfunction-associated FLD (MAFLD), is of growing importance for patients and health-care providers. Extrahepatic comorbidities, predominantly coronary artery disease (CAD), contribute to excess morbidity mortality in FLD. Although the association CAD well known, underlying pathophysiological links are not fully understood. Non-invasive means diagnostic enable a fast thorough characterization We therefore assessed severity cohort at...
Abstract Hepatic steatosis is a commonly seen phenomenon in clinical practice and the result of accumulation lipids hepatocytes. In most cases refers to nonalcoholic fatty liver disease (NAFLD), but it also occurs other diseases parenchyma different etiology dysregulation metabolic processes. Consequently, inflammatory processes can induce progressive fibrosis. Due high prevalence disease, further increase cirrhosis with corresponding complications be expected near future. its broad...
Background: Licensed therapies for nonalcoholic fatty liver disease (NAFLD) do not yet exist, but clinical trials are testing treatment options. Inclusion criteria often require biopsy showing fibrosis (F2/3) or cirrhosis (F4) and steatohepatitis (NASH). However, histological pose a serious obstacle recruitment.Aims: Characterize the relevance of biopsies in selection patients with NAFLD.Methods: Patients between 2013 2018 ICD-10 code K76.0 were analyzed. Fibrosis was defined by NASH...
Patient-reported outcomes are important in nonalcoholic fatty liver disease (NAFLD). Pruritus is of special interest for evolving therapies with farnesoid X receptor (FXR) agonists. The aim this study was to investigate the prevalence pruritus a real-life NAFLD cohort and analyze associations anxiety depression. assessed using visual analogue- (VAS) 5-D itch-scale (5-D). Anxiety depression were evaluated by Beck's-Depression-Inventory (BDI) Hospital Depression Scale (HADS-A, HADS-D). An...
Background and aims Transient elastography [vibration-controlled transient (VCTE)] noninvasively guides risk stratification in patients with nonalcoholic fatty liver disease (NAFLD). Patients steatohepatitis (NASH) fibrosis can be identified using the FAST-score. The maximum function test (LiMAx) could helpful more precise stratification. This pilot study evaluated VCTE, FAST-score, LiMAx NAFLD patients. Methods prospectively underwent VCTE LiMAx. cutoffs for high were 9.3/9.6 kPa...
Conventional ultrasound (US) is the first-line imaging method for abdominal pathologies, but its diagnostic accuracy operator-dependent, and data storage usually limited to two-dimensional images. A novel tomographic US system (Curefab CS, Munich, Germany) processes combined with three-dimensional spatial information using a magnetic field tracking. This enables standardized image presentation in axial planes review of entire examination. The applicability performance this approach was...
The prevalence of alveolar echinococcosis (AE) and cystic (CE) in Germany is increasing. number cases northern eastern regions low, so there little experience with regard to diagnosis therapy. objective this paper was evaluate the management suspected and/or diagnosed at a university center low-prevalence region. All patients Leipzig University Hospital between 2004 2018 who had been serologically examined for echinococci were included retrospective cohort study. Clinical course, imaging,...
Introduction Invasive liver abscess syndrome (ILAS) is caused by strains of hypervirulent Klebsiella pneumoniae (hvKp) and has emerged as the leading cause abscesses in immuno-competent patients (L.K. Siu et al. Lancet Infect Dis 2012; 12: 881–87). ILAS frequently associated with metastatic spread including eyes, lungs, central nervous system. The morbidity mortality affected are increased compared to other origin, especially cases concomitant diabetes mellitus (J. E. Choby J Intern Med...
Background It is commonly accepted that abdominal ultrasound imaging impaired in subjects with obesity, but data on the diagnostic impact of adiposity examination accuracy are scarce. High-performance probes implying innovative techniques to reduce disruptive effects obese patients aim at decreasing effect anthropometry quality.