A5000337837- Antibiotics Pharmacokinetics and Efficacy
- Antifungal resistance and susceptibility
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Antimicrobial Resistance in Staphylococcus
- Cancer Treatment and Pharmacology
- Pharmacogenetics and Drug Metabolism
- Cancer Immunotherapy and Biomarkers
- Neutropenia and Cancer Infections
- HER2/EGFR in Cancer Research
- Gene expression and cancer classification
- Drug-Induced Hepatotoxicity and Protection
- Renal Transplantation Outcomes and Treatments
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Antibiotic Resistance in Bacteria
- Nanoparticle-Based Drug Delivery
- Fungal Infections and Studies
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Lanthanide and Transition Metal Complexes
- Hepatocellular Carcinoma Treatment and Prognosis
- Statistical Methods in Clinical Trials
- Plant-based Medicinal Research
Chinese Academy of Sciences
2020-2024
Zhejiang Cancer Hospital
2018-2024
Nitto RIKEN (Japan)
2023
Cancer Hospital of Chinese Academy of Medical Sciences
2020-2022
University of Chinese Academy of Sciences
2020-2022
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2022
Tianjin Medical University
2015-2018
University of Florida
2018
Columbus Oncology and Hematology Associates
2018
BACKGROUND Gemcitabine/cisplatin (GP) resistance displays a negative role in treating advanced and metastatic non-small cell lung cancer (NSCLC). Several studies found that the association existed between platelets antigen 125 (CA125) with anticancer drugs. But exact correlation GP platelet activation index remains poorly understood. MATERIAL AND METHODS Pre-chemotherapy CA125 were retrospectively evaluated 169 NSCLC patients. All variables screened by chi-square test then log-rank test....
Background. Cuproptosis, a recently discovered form of cell death, is caused by copper levels exceeding homeostasis thresholds. Although Cu has potential role in colon adenocarcinoma (COAD), its the development COAD remains unclear. Methods. In this study, 426 patients with were extracted from Cancer Genome Atlas (TCGA) database. The Pearson correlation algorithm was used to identify cuproptosis-related lncRNAs. Using univariate Cox regression analysis, least absolute shrinkage and selection...
Results from the CASPIAN trial (Durvalumab ± Tremelimumab in Combination With Platinum Based Chemotherapy Untreated Extensive-Stage Small Cell Lung Cancer) demonstrated clinical benefit of durvalumab plus etoposide-platinum (EP) chemotherapy as first-line treatment for patients with extensive stage small-cell lung cancer (ES-SCLC). However, considering high price durvalumab, it is unclear whether addition to EP has economic value compared alone. In this study, we aimed evaluate...
Objectives: To evaluate the cost-effectiveness of 10 mg ilaprazole once-daily vs 20 omeprazole to treat newly-diagnosed duodenal ulcer patients in China.Methods: A decision tree model was constructed and treatment impact projected up 1 year. The CYP2C19 polymorphism distribution Chinese population, respective cure rates genotype sub-groups, Duodenal Ulcer (DU) on utility value drug-related side-effect data were obtained from literature. total costs medications calculated estimate based...
Regorafenib is a small‐molecule tyrosine kinase inhibitor with severe hepatotoxicity. It undergoes metabolism mainly by CYP3A4 to generate active metabolites regorafenib‐ N ‐oxide (M2) and ‐desmethyl‐regorafenib‐ (M5). Wuzhi capsule (WZC) an herbal preparation derived from Schisandra sphenanthera potentially used prevent regorafenib‐induced This study aims explore the effect of WZC on pharmacokinetics regorafenib in rats. An efficient sensitive liquid chromatography‐tandem mass spectrometry...
Pembrolizumab was recently demonstrated to have survival benefit in patients with recurrent or metastatic head and neck squamous cell carcinoma (r/mHNSCC). However, the cost-effectiveness of pembrolizumab versus chemotherapy China remains uncertain.This analysis aimed describe standard-of-care (SOC) therapy r/mHNSCC China.A Markov model consisting three health states (stable, progressive dead) developed compare cost effectiveness SOC platinum-resistant r/mHNSCC. Model inputs for transition...
To evaluate the impact of voriconazole on pharmacokinetics Non-steroidal anti-inflammatory drugs (NSAIDs). Pharmacokinetic and physiochemical properties NSAIDs are applied to build physiologically based pharmacokinetic (PBPK) models using GastroplusTM. The PBPK verified by published studies, respectively. After successful verification, DDI simulations predict effect NSAIDs. area under plasma concentration-time curves extrapolated infinity (AUC0-inf) celecoxib, ibuprofen, tenoxicam piroxicam...
The aim of this pharmacokinetic/pharmacodynamic (PK/PD) study is to evaluate the efficacy various isavuconazole dosing regimens for healthy individuals and patients with hepatic or renal impairment against Aspergillus spp. Candida Monte Carlo simulations were conducted using pharmacokinetic (PK) parameters pharmacodynamics (PD) data determine probabilities target attainment cumulative fractions response in terms area under concentration curve/minimum inhibition (AUC/MIC) targets...
Genetic polymorphisms of the P450 2C9 enzyme (CYP2C9), CYP2C19 and CYP3A5 gene are known to affect metabolism many drugs applied in liver transplant recipients, such as warfarin, voriconazole, tacrolimus. The aim this study was recommend dose regimens for recipients based on CYP2C9, CYP2C19, genotypic combinations their donors.91 adult Han Chinese who underwent orthotopic transplantation at Tianjin First Central Hospital, China, between 2013 2014 were included study. CYP2C9*2, CYP2C9*3,...
This study aimed to assess whether traditional initial loading and maintenance doses of teicoplanin were appropriate in endocarditis renal failure patients with methicillin-resistant Staphylococcus aureus (MRSA) infections recommend optimal dosage regimens. Pharmacokinetic parameters physicochemical properties performed develop pharmacokinetic models using GastroPlusTM. Concentration–time curves MRSA simulated by changing clearance (CL) volume distribution the central compartment (Vc)....
Lapatinib is an oral small-molecule tyrosine kinase inhibitor indicated for advanced or metastatic HER2-positive breast cancer. In order to reduce the treatment cost, a high-fat enteral nutrition emulsion TPF-T was selected as dose-sparing agent lapatinib-based therapies. This study aimed investigate effect of on lapatinib pharmacokinetics.First, simple and rapid liquid chromatography tandem mass spectrometry (LC-MS/MS) method developed quantitatively evaluate in rabbit plasma. The fully...
Aims Anlotinib is a novel oral tyrosine kinase inhibitor that targets VEGFR-2, VEGFR -3, FGFR1-4, PDGFR-α, PDGFR-β, c-Kit, and Ret. This study aimed to develop population pharmacokinetic model of anlotinib in patients with malignant tumors identify various covariates might affect its parameters. Methods 407 plasma concentrations from 16 were analyzed establish using the nonlinear mixed-effects method. All administered (12 mg) orally, as single drug therapy. The potential influence...
Omadacycline is an FDA-approved agent for community-acquired bacterial pneumonia (CABP). The purpose of this study to evaluate the effectiveness omadacycline treating CABP patients infected with
Objective We aimed to investigate the cost-effectiveness of tislelizumab plus chemotherapy compared alone as a first-line treatment for advanced or metastatic oesophageal squamous cell carcinoma (OSCC). Methods A partitioned survival model was developed evaluate versus in patients with OSCC over 10-year lifetime horizon from perspective Chinese healthcare system. Costs and utilities were derived drug procurement platform published literature. The outcomes comprised costs, quality-adjusted...
Linezolid is an alternative first-line agent for MRSA pneumonia. This study assessed whether dose adjustments of linezolid against methicillin-resistant Staphylococcus aureus (MRSA) infections were needed based on renal function in populations with different body weight.Monte Carlo simulations conducted to evaluate relation the probability target attainment (PTA) three population groups weight. Area under concentration time curve (AUC)/ minimum inhibitory (MIC) ratio and percentage above MIC...