A5034702319- Cystic Fibrosis Research Advances
- Inflammasome and immune disorders
- interferon and immune responses
- Heme Oxygenase-1 and Carbon Monoxide
- Vibrio bacteria research studies
- Immune Response and Inflammation
- Gut microbiota and health
- Infant Nutrition and Health
- Probiotics and Fermented Foods
- Erythrocyte Function and Pathophysiology
- Legume Nitrogen Fixing Symbiosis
- Pediatric Hepatobiliary Diseases and Treatments
- Burkholderia infections and melioidosis
- Mosquito-borne diseases and control
- Neonatal Respiratory Health Research
Dartmouth College
2020-2024
Hospital of the University of Pennsylvania
2023
Queen's University Belfast
2023
Stony Brook University
2020
The composition of the gut microbiome in persons with CF is correlated lung health outcomes, a phenomenon referred to as gut-lung axis. Here, we demonstrate that intestinal microbe Bacteroides decreases inflammation through production short-chain fatty acid propionate. Supplementing levels an animal model associated reduced systemic and reduction relative abundance opportunistically pathogenic group Escherichia / Shigella gut. Taken together, these data key role for microbially produced...
Burkholderia cenocepacia is a member of the cepacia complex (Bcc), group bacteria with members responsible for causing lung infections in cystic fibrosis (CF) patients. The most severe outcome Bcc infection CF patients syndrome, disease characterized by necrotizing pneumonia bacteremia and sepsis. B. strongly associated making it one virulent Bcc. Mechanisms underlying pathogenesis syndrome remain to be uncovered. primarily an intracellular pathogen encodes type VI secretion system (T6SS)...
Pyrin, a unique cytosolic receptor, initiates inflammatory responses against RhoA-inactivating bacterial toxins and effectors like Yersinia's YopE YopT. Understanding pyrin regulation is crucial due to its association with dysregulated responses, including Familial Mediterranean Fever (FMF), linked gene mutations. FMF mutations historically acted as defense mechanism plague. Negative of through PKN phosphorylation well established, Yersinia using the YopM effector promote counteract...
ABSTRACT Persons with cystic fibrosis, starting in early life, have intestinal microbiome dysbiosis characterized part by a decreased relative abundance of the genus Bacteroides . is major producer short chain fatty acid (SCFA) propionate. We demonstrate here that CFTR-/- Caco-2 epithelial cells are responsive to anti-inflammatory effects Furthermore, isolates inhibit IL-1β-induced inflammatory response and do so propionate-dependent manner. also produce low levels butyrate; this SCFA...
The
Abstract Pyrin is a pattern-recognition receptor in phagocytes that triggers capase-1 inflammasome assembly response to bacterial toxins and effectors inactivate RhoA. contains oligomerization domains negatively regulated by phosphorylation of two residues, S205 S241 (murine) or S208 S242 (human), via the kinases PKN1/2, which are activated Familial Mediterranean Fever (FMF) caused phagocyte production pyrin gain function variants, have lower threshold for upon RhoA-PKN axis inhibition....
The
Abstract Burkholderia cenocepacia (Bc) is a member of the cepacia complex (Bcc), group bacteria with members responsible for causing lung infections in cystic fibrosis (CF) patients. The most severe outcome Bcc infection CF patients syndrome, disease characterized by necrotizing pneumonia bacteremia and sepsis. Bc strongly associated syndrome making it one virulent Bcc. Mechanisms underlying pathogenesis remain to be uncovered. primarily an intracellular pathogen, encodes type VI secretion...