A5062170356- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Synthesis of β-Lactam Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Oxidative Organic Chemistry Reactions
- Radical Photochemical Reactions
- Cyclopropane Reaction Mechanisms
- Asymmetric Hydrogenation and Catalysis
- Synthetic Organic Chemistry Methods
- Crystallization and Solubility Studies
- Chemical Synthesis and Analysis
- Catalytic Cross-Coupling Reactions
- Microbial Natural Products and Biosynthesis
- X-ray Diffraction in Crystallography
Princeton University
2021-2024
University of North Carolina Wilmington
2024
Stanford University
2018-2019
Drew University
2013
A general and operationally convenient method for intermolecular amination of C(sp3 )-H bonds is described. This technology allows efficient functionalization complex molecules, including numerous pharmaceutical targets. The combination pivalonitrile as a solvent, Al2 O3 an additive, phenyl sulfamate nitrogen source affords differential reaction performance substrate scope. Mechanistic data strongly implicate pathway catalyst decomposition that initiates with solvent oxidation, thus...
A light-driven method for the generation of aryl radicals from triarylbismuth(III) and (V) reagents is described. Aryl radical proposed to occur through ligand-assisted mesolytic cleavage an organobismuth(IV) intermediate generated either oxidation BiIII or reduction BiV. This mode demonstrated be compatible with a range bimolecular arylations, including hydroarylation electron-deficient olefins arylation diboronates, disulfides, sulfonyl cyanides, phosphites, isocyanides. The intermediacy...
Abstract A general and operationally convenient method for intermolecular amination of C(sp 3 )−H bonds is described. This technology allows efficient functionalization complex molecules, including numerous pharmaceutical targets. The combination pivalonitrile as a solvent, Al 2 O an additive, phenyl sulfamate nitrogen source affords differential reaction performance substrate scope. Mechanistic data strongly implicate pathway catalyst decomposition that initiates with solvent oxidation,...
The preparation of substituted azetidines and larger ring, nitrogen-containing saturated heterocycles is enabled through efficient selective intermolecular sp3-C–H amination alkyl bromide derivatives. A range substrates are demonstrated to undergo C–H subsequent sulfamate alkylation in good excellent yield. N-Phenoxysulfonyl-protected products can be unmasked under neutral or mild basic conditions yield the corresponding cyclic secondary amines. preparative convenience this protocol...
The desire for maximally efficient transformations in complex molecule synthesis has contributed to a surge of interest C–H functionalization methods development recent years. In contrast the steady stream methodological reports, however, there are noticeably fewer studies comparing efficacies different protocols on single structurally intricate substrate. Recognizing importance heteroatom incorporation synthesis, this report discloses comparative examination diverse strategies C–O, C–N, and...
The preparation of substituted azetidines and larger-ring, nitrogen-containing saturated heterocycles is enabled through efficient selective intermolecular sp<sup>3</sup>-C–H amination alkyl bromide derivatives. A range substrates demonstrated to undergo C–H subsequent sulfamate alkylation in good excellent yield. <i>N</i>-Phenoxysulfonyl-protected products can be unmasked under neutral or mild basic conditions yield the corresponding cyclic 2° amines. preparative...
The preparation of substituted azetidines and larger-ring, nitrogen-containing saturated heterocycles is enabled through efficient selective intermolecular sp 3 -C–H amination alkyl bromide derivatives. A range substrates demonstrated to undergo C–H subsequent sulfamate alkylation in good excellent yield. N -Phenoxysulfonyl-protected products can be unmasked under neutral or mild basic conditions yield the corresponding cyclic 2° amines. preparative convenience this protocol gram-scale...