A5014576358- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Click Chemistry and Applications
- Metal-Catalyzed Oxygenation Mechanisms
- Chemical Synthesis and Analysis
- Oxidative Organic Chemistry Reactions
- Multicomponent Synthesis of Heterocycles
- Synthesis and Biological Evaluation
- Computational Drug Discovery Methods
- Complementary and Alternative Medicine Studies
- Genetics, Bioinformatics, and Biomedical Research
- Biotin and Related Studies
- Chemical Synthesis and Reactions
- Antibiotic Use and Resistance
- Pharmaceutical Practices and Patient Outcomes
- Iron Metabolism and Disorders
- Mesoporous Materials and Catalysis
- Cancer Treatment and Pharmacology
- Viral Infections and Immunology Research
- Food Security and Health in Diverse Populations
- Supercapacitor Materials and Fabrication
- Machine Learning in Materials Science
- Microtubule and mitosis dynamics
- X-ray Diffraction in Crystallography
- Carbohydrate Chemistry and Synthesis
Arrien Pharmaceuticals (United States)
2025
Recursion (United States)
2025
South College
2022-2024
Exscien (United States)
2023
GlaxoSmithKline (United States)
2022
University of Illinois Urbana-Champaign
2022
Stanford University
2013-2018
Discovery Institute
2016
Cornell University
2008-2012
Selective hydroxylation of 3° and benzylic C–H bonds is made possible using a non-metal-based catalyst system, Oxone as the terminal oxidant, an aqueous fluoroalcohol solvent mixture. The choice uniquely effective for this process, but seemingly at odds with our finding that H2O promotes reduction oxaziridine intermediate. Our studies suggest reaction occurring within microdroplet, which both concentrates reactants mitigates deleterious impact on stability. These discoveries have led to...
A comparative study is disclosed that seeks to highlight the current limitations and challenges exist in field of atom-transfer C–H oxidations. State-of-the-art methods are benchmarked order showcase clear differences similarities. novel Mn-mediated method for oxidation serves as a rapid simple aliphatic hydroxylation. Finally, two allow presence pyridine-containing substrates studied, something rare but great interest chemical community.
The desire for maximally efficient transformations in complex molecule synthesis has contributed to a surge of interest C–H functionalization methods development recent years. In contrast the steady stream methodological reports, however, there are noticeably fewer studies comparing efficacies different protocols on single structurally intricate substrate. Recognizing importance heteroatom incorporation synthesis, this report discloses comparative examination diverse strategies C–O, C–N, and...
Using the Passerini and Ugi reactions as representative tests, utility of several α-substituted ketones R−CO−CH2−X (X = sulfonyloxy, acyloxy, azido, halo, hydroxy, sulfonyl) in isonitrile-based multicomponent was explored. In a relative rate study (R PhCH2CH2), each underwent condensation more rapidly than parent ketone. Short, highly convergent routes to oxazoline, β-lactam, di-O-acylglyceramides, other molecular frameworks were developed.
Mechanistic insight into the C–H hydroxylation reaction catalysed by [(Me<sub>3</sub>tacn)RuCl<sub>3</sub>] has been obtained using desorption electrospray ionization mass spectrometry (DESI-MS) to identify reactive intermediates and determine fate of starting metal complex.
In this Letter, we adapt a recently reported Pd-catalyzed transannular C(sp3)-H arylation of alicyclic amines for applications in fragment-based drug discovery (FBDD). We apply method to the synthesis series 6-arylated 3-azabicyclo[3.1.0]hexanes that are rule-of-three compliant fragments. Several modifications were made C-H enhance its utility fragment synthesis. These include use microwave heating shorten reaction times under 1 h and development new approaches directing group cleavage....
In the aftermath of COVID-19 pandemic, opportunities to modulate biological pathways common lifecycles viruses need be carefully considered.
Abstract Background Violent crime (i.e., homicide, armed robbery, aggravated assault, and rape) continues to be a major public health concern in America. Several studies have linked the availability density of specific features retail food environment, such as convenience stores liquor stores, violent rates due criminal activity that often occurs near these retailers. Nevertheless, there limited understanding how other (e.g., grocery supercenters, restaurants, etc.) are associated with...
Abstract A novel and rapid Mn‐mediated method for aliphatic C—H hydroxylation is described.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
ADVERTISEMENT RETURN TO ISSUEPREVIn This IssueNEXTIn Issue, Volume 10, Issue 7Ashley M. AdamsAshley AdamsMore by Ashley Adams and Terry W. MooreTerry MooreMore Moorehttp://orcid.org/0000-0002-5410-306XCite this: ACS Med. Chem. Lett. 2019, 7, 1015Publication Date (Web):July 11, 2019Publication History Published online11 July 2019Published inissue 11 2019https://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00288https://doi.org/10.1021/acsmedchemlett.9b00288in-briefACS PublicationsCopyright © 2019...