A5083602330- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Analytical Methods in Pharmaceuticals
- Cell Image Analysis Techniques
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Image Processing Techniques and Applications
- Advanced Vision and Imaging
- Genetic Associations and Epidemiology
- COVID-19 and healthcare impacts
- Child Abuse and Trauma
- Health, Environment, Cognitive Aging
- COVID-19 epidemiological studies
- Metabolism and Genetic Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Cholesterol and Lipid Metabolism
- Chronic Myeloid Leukemia Treatments
- Social and Educational Sciences
- Bioinformatics and Genomic Networks
- Diet and metabolism studies
- Antibiotics Pharmacokinetics and Efficacy
- Advanced Fluorescence Microscopy Techniques
- Neuroendocrine Tumor Research Advances
- Gene expression and cancer classification
- Pharmacogenetics and Drug Metabolism
Uppsala University
2006-2025
Lund University
2023
Analysis of single-cell data has emerged as a powerful tool for studying biological processes and response to perturbations. However, its application in morphological profiling is less explored. In this study we profile six cell death subtypes induced by 50 small molecule drugs across concentrations using the Cell Painting assay. We evaluate performance three feature extraction methods at aggregated level apply supervised unsupervised analyses uncover factors contributing mechanisms. Our...
The aim of this study in pigs was to investigate the local pharmacokinetics fexofenadine intestine and liver by using pig as a model for drug transport entero-hepatobiliary system. A parallel group design included seven (10–12 weeks, 22.2–29.5 kg) three groups (G1, G2, G3), jejunal single-pass perfusion combined with sampling from bile duct portal, hepatic, superior caval veins performed. Fexofenadine perfused through segment alone (G1: 120 mg/l, total dose 24 mg) or two different verapamil...
The hepatobiliary transport and local disposition of rosuvastatin in pig were investigated, along with the impact concomitant dosing two known multiple inhibitors; cyclosporine gemfibrozil. Rosuvastatin (80 mg) was administered as an intrajejunal bolus dose treatments I, II, III (TI, TII, TIII, respectively; <i>n</i> = 6 per treatment). Cyclosporine (300 gemfibrozil (600 addition to TII respectively. a 2-h intravenous infusion dose. In treatment IV (TIV, 4) 5.9 mg study conducted using...
Fluorescence microscopy, which visualizes cellular components with fluorescent stains, is an invaluable method in image cytometry. From these images various features can be extracted. Together form phenotypes that used to determine effective drug therapies, such as those based on nanomedicines. Unfortunately, fluorescence microscopy time-consuming, expensive, labour intensive, and toxic the cells. Bright-field lack downsides but also clear contrast of hence are difficult use for downstream...
The effect of a single intrajejunal dose gemfibrozil (600 mg) on the plasma pharmacokinetics and biliary excretion rosuvastatin (20 was investigated by using multichannel catheter positioned in distal duodenum‐proximal jejunum 8 healthy volunteers. Bile samples were collected every 20 minutes for 200 minutes, with additional being drawn up to 48 hours. Gemfibrozil did not affect bioavailability rosuvastatin, although it increased apparent absorption phase during initial (AUC plasma, 200min )...
Abstract Fluorescence microscopy, which visualizes cellular components with fluorescent stains, is an invaluable method in image cytometry. From these images various features can be extracted. Together form phenotypes that used to determine effective drug therapies, such as those based on nanomedicines. Unfortunately, fluorescence microscopy time-consuming, expensive, labour intensive, and toxic the cells. Bright-field lack downsides but also clear contrast of hence are difficult use for...
Hepatobiliary transporters efficiently shunt rosuvastatin from the blood stream, into hepatocyte, followed by transporter-mediated excretion bile ducts.This study aimed at investigating contribution of sinusoidal versus canalicular transport on pharmacokinetics an intrajejunal dose 80 mg in pigs (control group, n = 2 + 6). The inhibitors, rifampicin (20 mg/kg, 6) and imatinib (14 6), were administered as 2-h long intravenous infusions. Plasma samples withdrawn portal hepatic vein...
Data regarding excretion of SARS-CoV-2 in semen are inconclusive and counseling risk sexual transmission is still challenging. Our knowledge on the effect upper respiratory tract infections (URTI) male reproductive system also scarce. Apart from negative fever spermatogenesis virtually no study has been able to compare parameters men with COVID-19 or other URTI predisease data. Eleven who developed symptoms during first second wave pandemic had preexistent fertility hormonal data,...