A5082209540- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
- Nerve injury and regeneration
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Autism Spectrum Disorder Research
- Neuroscience and Neural Engineering
- Pluripotent Stem Cells Research
- Barrier Structure and Function Studies
- Medicinal Plants and Neuroprotection
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
University of Oxford
2022-2024
The University of Sydney
2020-2022
Alzheimer's disease (AD) is an age-related neurodegenerative condition and the most common type of dementia, characterised by pathological accumulation extracellular plaques intracellular neurofibrillary tangles that mainly consist amyloid-β (Aβ) hyperphosphorylated tau aggregates, respectively. Previous studies in mouse models with a targeted knock-out microtubule-associated protein (Mapt) gene demonstrated Aβ-driven toxicity tau-dependent. However, human cellular chronic lowering remain...
Some aged community dogs acquire a degenerative syndrome termed Canine Cognitive Dysfunction (CCD) that resembles human dementia because of Alzheimer's Disease (AD), with comparable cognitive and behavioral deficits. Dogs also have similar neuroanatomy, share our domestic environment develop amyloid-β plaques, making them likely valuable ecological model AD. However, prior investigations demonstrated lack neurofibrillary tau pathology in dogs, an important hallmark AD, though elevated...
Older companion dogs naturally develop a dementia-like syndrome with biological, clinical and therapeutic similarities to Alzheimer disease (AD). Given there has been no new safe, clinically effective widely accessible treatment for AD almost 20 years, an all-new cell approach was trialled in canine veterinary patients, further modelled aged rats more detailed neurobiological analysis. A Phase 1/2A trial conducted N = 6 older definitive diagnosis of Canine Cognitive Dysfunction (CCD)....
Abstract Background Alzheimer’s (AD) and Parkinson’s disease (PD) feature progressive neurodegeneration in a remarkably regionally selective manner. Post mortem studies have posited role for cell autonomous mechanisms driving this, so we aimed to examine live human induced pluripotent stem (iPSC) model see whether it can replicate the phenomenon of neuronal vulnerability, better determine therapeutic targets. Method iPSC‐derived neurons offer rare opportunity vulnerability cells. iPSCs from...
Abstract Background Alzheimer’s disease (AD) is an age-related neurodegenerative condition and the most common type of dementia, characterised by pathological accumulation extracellular plaques intracellular neurofibrillary tangles that mainly consist amyloid-β (Aβ) hyperphosphorylated tau aggregates, respectively. Previous studies in mouse models with a targeted knock-out microtubule-associated protein (Mapt) gene demonstrated Aβ-driven toxicity tau-dependent. However, human cellular...
Abstract Background Alzheimer’s and Parkinson’s disease feature progressive neurodegeneration associated with the accumulation of protein aggregates in a remarkably regionally selective manner. The cortical neurons that are relatively vulnerable Disease (AD) only affected late (PD), whereas midbrain dopaminergic exhibit striking vulnerability PD, but spared AD. Rodent human post mortem studies have posited role for cell autonomous mechanisms such as autophagy or calcium buffering deficits...