A5019758607- Sleep and Wakefulness Research
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Neuroscience of respiration and sleep
- Sleep and related disorders
- Obstructive Sleep Apnea Research
- Tracheal and airway disorders
- Respiratory Support and Mechanisms
- Metabolism and Genetic Disorders
- Cystic Fibrosis Research Advances
- Neonatal and fetal brain pathology
- Health Systems, Economic Evaluations, Quality of Life
- NF-κB Signaling Pathways
- Myasthenia Gravis and Thymoma
- Thyroid and Parathyroid Surgery
- Immune Response and Inflammation
- Pharmaceutical Practices and Patient Outcomes
- Cell death mechanisms and regulation
- Medication Adherence and Compliance
St George's Hospital
2022-2025
Great Ormond Street Hospital
2016-2025
University College London
2011-2025
St George's, University of London
2025
Alice Ho Miu Ling Nethersole Hospital
2013
Please note that sleep-disordered breathing (SDB) in children without comorbidities is related to snoring and upper airway obstruction commonly referred as obstructive sleep apnoea (OSA). ### Diagnosing with suspected #### Sleep questionnaires, combined questionnaires 'protocol-driven' clinical assessments, video recordings audio ##### Children ###### Recommendations Good practice points point Pulse oximetry CRSS Recommendation
Abstract Objective The relationship between sleep and epilepsy is important but imperfectly understood. We sought to understand the mechanisms that explain differences in homeostasis observed children with epilepsy. Methods used a neural mass model replicate electroencephalography (EEG) recorded from 15 focal lesional epilepsies 16 healthy age‐matched controls. Different parameter sets were recovered for each subject. Results revealed EEG are driven by enhanced firing rates neuronal...
Summary Objective Children with epilepsy have high rates of both cognitive impairment and sleep disruption. It is thus assumed that sleep‐dependent memory consolidation vulnerable to ongoing epileptic activity, but direct evidence this limited. Methods We performed a within‐subject comparison retention across intervals wake or overnight sleep. Healthy children (n = 21, 6–16 years, 12 female) focal 22, 9 verbal visuospatial tasks under each condition. Sleep was assessed electroencephalography...
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, usually arising from a background chronic inflammatory disease. Tumor necrosis factor alpha (TNF-alpha) pro-inflammatory cytokine produced in response to tissue injury, endotoxin exposure or infection and TNF-alpha signalling hepatocytes associated with an increase oxidative stress. DNA vulnerable reactive oxygen species (ROS)-induced damage, which highly mutagenic. Cells respond damage through stabilisation tumor...
To investigate the link between sleep disruption and cognitive impairment in childhood epilepsy by studying effect of on homeostasis, as reflected slow-wave activity (SWA).We examined SWA from overnight EEG-polysomnography 19 children with focal (mean [SD] age 11 years 6 months [3 years], range months-15 months; females, 13 males) 18 age- sex-matched typically developing controls, correlating this contemporaneous memory consolidation task scores, full-scale IQ, seizures, interictal...
Abstract Respiratory problems are a major cause of morbidity and mortality in patients with congenital myasthenic syndromes, rare heterogeneous group neuromuscular disorders caused by genetic defects impacting the structure function junction. Recurrent, life-threatening episodic apnoea early infancy childhood progressive respiratory failure requiring ventilation features certain genotypes syndromes. Robb et al. published empirical guidance on management but other than this workshop report,...
Abstract Objective The relationship between sleep and epilepsy is important but imperfectly understood. We sought to understand why children with have altered homeostasis. Methods used neural mass models replicate EEG recorded from 15 focal lesional epilepsies 16 healthy age-matched controls. Results revealed that differences are driven by enhanced firing rates in the neuronal populations of patients, which arise predominantly due excitatory synaptic currents. These were more marked patients...
Abstract Objective Sleep disruption and cognitive impairment are important co-morbidities in childhood epilepsy, yet a mechanistic link has not been substantiated. Slow wave activity during sleep its homeostatic decrease across the night is associated with synaptic renormalisation, shows maturational changes over course of childhood. Here, we aimed to investigate effect epilepsy on homeostasis developing brain. Methods We examined relationship as reflected slow seizures, cognition behaviour,...