A5057711738- Heavy Metal Exposure and Toxicity
- Nanoparticles: synthesis and applications
- Carbon and Quantum Dots Applications
- Graphene and Nanomaterials Applications
- Sulfur Compounds in Biology
- Neuroscience and Neural Engineering
- Bone fractures and treatments
- Electrochemical sensors and biosensors
- Orthopedic Surgery and Rehabilitation
- Photoreceptor and optogenetics research
- Nitric Oxide and Endothelin Effects
- Noise Effects and Management
- Ultrasonics and Acoustic Wave Propagation
- Neonatal Health and Biochemistry
- Healthcare and Environmental Waste Management
- Caveolin-1 and cellular processes
- Infrared Thermography in Medicine
- Inflammasome and immune disorders
- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- Cholinesterase and Neurodegenerative Diseases
- Lipoproteins and Cardiovascular Health
- Allergic Rhinitis and Sensitization
- Diabetes, Cardiovascular Risks, and Lipoproteins
- CCD and CMOS Imaging Sensors
Laboratoire de Chémo-biologie synthétique et thérapeutique
2011-2023
Université de Strasbourg
2011-2023
Centre National de la Recherche Scientifique
2011-2023
Inserm
2018
Cibles thérapeutiques, formulation et expertise préclinique du médicament
2014-2017
Université de Lorraine
2014
University of Milan
1990
Abstract Background A positive surface charge has been largely associated with nanoparticle (NP) toxicity. However, by screening a carbon NP library in macrophages, we found that cationic does not systematically translate into To get deeper insight this, carried out comprehensive study on 5 NPs (NP2 to NP6) exhibiting similar zeta (ζ) potential value (from + 20.6 26.9 mV) but displaying an increasing density (electrokinetic charge, Q ek from 0.23 4.39 µmol/g). An anionic and non-cytotoxic...
Carbon dots are emerging nanoparticles (NPs) with tremendous applications, especially in the biomedical field. Herein is reported first quantitative proteomic analysis of protein corona formed on CDs different surface charge properties. Four were synthesized from citric acid and various amine group-containing passivation reagents, resulting cationic NPs increasing zeta (ζ)-potential density positive charges. After CD contact serum, we show that identity influenced by properties, which turn...
(1) Background: Epiregulin (EREG) is a ligand of EGFR and ErB4 involved in the development progression various cancers including head neck squamous cell carcinoma (HNSCC). Its overexpression HNSCC correlated with short overall survival progression-free but predictive tumors responding to anti-EGFR therapies. Besides tumor cells, macrophages cancer-associated fibroblasts shed EREG microenvironment support promote therapy resistance. Although seems be an interesting therapeutic target, no...
Total bone mineral and density modifications were evaluated during fracture healing of long bones in patients with traumatic fractures the lower limbs, using an experimental model based on dual photonabsorptiometry technique. Seven (five males two females; mean age, 19.5 years; range, 17-23 years) tibia fibula midshaft open treated osteosynthesis studied. Dual energy gadolinium-153 was used to measure distal leg loss at a skeletal segment distant from exclude callus formation. (TBM) (BMD)...
With the growth of nanotechnologies, concerns raised regarding potential adverse effects nanoparticles (NPs), especially on respiratory tract. Adverse outcome pathways (AOP) have become recently subject intensive studies in order to get a better understanding mechanisms NP toxicity, and hence hopefully predict health risks associated with exposure. Herein, we propose putative AOP for lung toxicity NPs using emerging nanomaterials called carbon dots (CDs), vivo vitro experimental approaches....
S-Nitrosoglutathione (GSNO) is a good candidate for nitric oxide (NO•) delivery, and its nanoformulation improves NO• stability bioavailability. We have compared the effect of empty Eudragit nanoparticles (eENP), GSNO-loaded ENP (gENP), free GSNO on THP-1 human monocytic cell line. investigated cellular viability growth by WST-1 trypan blue tests. uptake was studied using transmission electron microscopy, confocal flow cytometry. Transcriptomic profiles were obtained microarray. entered...
Due to their unique properties, engineered nanoparticles (NPs) have found broad use in industry, technology, and medicine, including as a vehicle for drug delivery. However, the understanding of NPs’ interaction with different types mammalian cells lags significantly behind increasing adoption In this study, we show responses human epithelial breast when exposed polymeric Eudragit® RS NPs (ENPs) 1–3 days. Cells displayed dose-dependent increases metabolic activity growth, but lower...
Abstract With three models in commercial use, artificial retinas are the most concrete hope to restore sight blind patients, notably those affected with retinitis pigmentosa. However, present architectures costly produce, while restored visual acuity remains below legal threshold for blindness. Furthermore, complexity of current systems tethered application‐specific integrated circuits (asics) requires complex surgeries, risks complications and failures. In search new nanomaterials, it is...
S-nitrosoglutathione (GSNO) is a potential therapeutic for infectious disease treatment because of its pivotal role in macrophage-mediated inflammatory responses and host defense addition to direct antibacterial activities. In this study, sterically stabilized cationic liposomes (SSCL) anionic (SSAL) were developed as nanocarriers macrophage targeting. Elaborated characterized terms size, zeta potential, morphology, encapsulation efficiency, vitro drug release behavior cytotoxicity. Their...
Carbon nanomaterials, including carbon dots (CDs), form a growing family of engineered nanoparticles (NPs) with widespread applications. As the rapid expansion nanotechnologies raises safety concerns, interaction NPs immune system is receiving lot attention. Recent studies have reported that may induce macrophage death by pyroptosis. Therefore, this study investigated whether cationic CDs pyroptosis in human macrophages and assessed role inflammasome lysosome process. Cationic were...
Pharmacognostical standardization and toxicity profile of the methanolic leaf extract Plectranthus amboinicus (Lour) SprengPreeja G. Pillai, P. Suresh, Gayatri Aggarwal, Gaurav Doshi, Vidhi Bhatia
This study aimed at discriminating with sensitivity the toxicological effects of carbon dots (CDs) various zeta potential (ζ) and charge density (Qek) in different cellular models human respiratory tract. One anionic three cationic CDs were synthetized as follows: CD-COOH (ζ = −43.3 mV); CD-PEI600 (Qek 4.70 µmol/mg; ζ +31.8 CD-PEHA 3.30 +29.2 mV) CD-DMEDA 0.01 +11.1 mV). Epithelial cells (A549) macrophages (THP-1) seeded alone or co-cultures A549:THP-1 ratios. The obtained characterized,...
S-nitrosogluthatione (GSNO), a S-nitrosothiol, is commonly used as nitric oxide (NO•) donor. However, its half-life too short for direct therapeutic use. To protect and ensure sustained release of NO•, the encapsulation GSNO into nanoparticles may be an interesting option.In this work, we have investigated early (4 h) late (24 transcriptomic response THP-1 human monocytes cells to two doses (1.4 6 µM) either free or Eudragit® nano-encapsulated using RNA microarray.After exposure GSNO, genes...