A5082705188- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Heart Failure Treatment and Management
- Iron Metabolism and Disorders
- Intensive Care Unit Cognitive Disorders
- Erythropoietin and Anemia Treatment
- Chronic Disease Management Strategies
- Patient Safety and Medication Errors
- Respiratory Support and Mechanisms
- Hemoglobinopathies and Related Disorders
- Healthcare Technology and Patient Monitoring
- Potassium and Related Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Pharmaceutical Practices and Patient Outcomes
- Cardiac Arrest and Resuscitation
- Esophageal and GI Pathology
- Gallbladder and Bile Duct Disorders
- Healthcare Systems and Practices
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Quality and Safety in Healthcare
- Human-Automation Interaction and Safety
- Pancreatic and Hepatic Oncology Research
- Alcohol Consumption and Health Effects
Queen Alexandra Hospital
2015-2024
John Radcliffe Hospital
2024
Oxford University Hospitals NHS Trust
2024
Portsmouth Hospitals NHS Trust
2017-2023
The Recovery Center
2022
Nepal Health Research Council
2021
NIHR Clinical Research Network
2021
National Institute for Health Research
2021
National Records of Scotland
2021
Intensive Care National Audit & Research Centre
2021
Abstract Background and Aims What is the relationship between blood tests for iron deficiency, including anaemia, response to intravenous in patients with heart failure? Methods In IRONMAN trial, 1137 failure, ejection fraction ≤ 45%, either serum ferritin < 100 µg/L or transferrin saturation (TSAT) 20% were randomized ferric derisomaltose (FDI) usual care. Relationships investigated baseline anaemia severity, TSAT, changes haemoglobin from 4 months, Minnesota Living Heart Failure...
Objective To describe the population, heart failure (HF) diagnosis rate, and 1-year hospitalisation mortality of patients with suspected HF elevated N-terminal pro B-type natriuretic peptide (NTproBNP) investigated according to UK National Institute for Health Care Excellence (NICE) guidelines. Methods NICE recommends HF, based on clinical presentation NTproBNP, are referred specialist assessment echocardiography. Patients should be seen within 2 weeks when NTproBNP is >2000 pg/mL (2-week...
<h3>Introduction</h3> Renin-angiotensin-aldosterone-system inhibitors (RAASi) are commonly used for a number of indications, including in the management hypertension, proteinuric chronic kidney disease (CKD), post myocardial infarction and heart failure with reduced ejection fraction (HFrEF). Their use is often hindered by hyperkalaemia leading to underutilisation and/or underdosing. <h3>Purpose</h3> Assess perceptions primary secondary healthcare professionals regarding benefits RAASi...
Objective To understand human factors (HF) contributing to disturbances during invasive cardiac procedures, including frequency and nature of distractions, assessment operator workload. Methods Single centre prospective observational evaluation 194 procedures in three adult catheterisation laboratories over 6 weeks. A proforma frequency, nature, magnitude level procedural risk at the time each distraction/interruption was completed for case. The primary a National Aeronautical Space...
BackgroundIn some countries, intravenous (IV) ferric derisomaltose (FDI) is only licensed for treating iron deficiency with anemia. Accordingly, we investigated the effects of FDI in a subgroup patients anemia IRONMAN trial.Method and ResultsIRONMAN enrolled heart failure, left ventricular ejection fraction (LVEF) ≤45% (ferritin <100 µg/L or TSAT <20%), 771 (68%) whom had (hemoglobin <12 g/dL women; <13 men). Patients were randomized, open-label, to (n=397) usual care (n=374) followed median...
A wide range of medications including antimalarial preparations (chloroquine, hydroxychloroquine), macrolide antibiotics (azithromycin) and the interleukin-6 inhibitor (tocilizumab) may be effective in treating patients with coronavirus disease 2019 (COVID-19). Such agents associated cardiotoxicity, purpose this brief review is to draw attention potential areas pharmacovigilance. These include prolongation QT-interval development occult cardiomyopathy. Alternatively, some seem have minimal...
<h3>Background</h3> Inhibitors of the Renin-angiotensin-aldosterone-system (RAASi) offer prognostic advantages in heart failure with reduced ejection fraction (HFrEF), after myocardial infarction (MI) and for those chronic kidney disease (CKD). Nevertheless, when patients develop hyperkalaemia RAASi dosage might be lowered or discontinued, potentially leading to unfavourable outcomes. <h3>Purpose</h3> A prospective observational study at a single center analysed real-world data patient's...
<h3>Introduction</h3> Palpitations, pre-syncope and syncope is a common presentation to cardiology services. Short monitoring with conventional Holter monitor or cardiac memo often not sufficient for the detection of paroxysmal arrhythmia. The aims this project were: (i) demonstrate symptom-rhythm correlation novel ambulatory ECG devices, (ii) short time diagnosis patient presenting palpitation, syncope, (iii) assess experience.Method: Patients referred local Cardiology Department symptoms...
<b>Background:</b> The management of IPF has changed since the introduction anti-fibrotic agents Pirfenidone (Pirf) and Nintedanib (Nin) however, there are no studies on head to comparison these agents. <b>Aims:</b> To examine real-world tolerability, efficacy safety Pirf Nin in patients with a diagnosis <b>Methods:</b> We conducted retrospective single centre records review 71 who received or for between Sep 2013 Aug 2016. Data was collected diagnosis, demographics, pulmonary function...
<h3>Purpose</h3> To understand factors contributing to disturbances during cardiac procedures, including frequency and nature of distractions, along with assessment operator 'work-load' through NASA Task-load indices. <h3>Methods</h3> A single centre prospective observational study was conducted on 194 consecutive patients undergoing procedures in 3 adult CL's over a period 4 weeks. distraction pro-forma completed for each case by CL team members (predominantly physiologists), documenting...
<h3>Introduction</h3> Chronic heart failure (HF) represents a substantial and growing public health financial burden has poor prognosis. National Institute for Health Care Excellence (NICE) guidelines quality standards recommend timely specialist assessment patients with suspected HF raised natriuretic peptides. However, data on the outpatient population assessed, diagnostic rates of outcomes this pathway are not known. This is in contrast to hospitalised acute who well described UK. Our aim...
<h3>Introduction</h3> Atrial fibrillation (AF) is a global public health priority. An unsolved problem how to detect paroxysmal AF. Patients presenting with palpitations are usually monitored for short period of time conventional 24 hour Holter monitor or 72 hours cardiac memo. As result, it likely that AF being routinely underdiagnosed and undertreated. This service evaluation reviewed the proportion patients amongst those who investigated palpitations/pre-syncope/syncope by Cardiology...