A5049398218- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Neurogenetic and Muscular Disorders Research
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Pneumocystis jirovecii pneumonia detection and treatment
- Muscle Physiology and Disorders
- CRISPR and Genetic Engineering
- Glioma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Renal and Vascular Pathologies
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
Massachusetts General Hospital
2024
Pfizer (United Kingdom)
2022
Cardiac amyloidosis is frequently misdiagnosed, denying patients the opportunity for timely and appropriate management of disease. The purpose this review case studies to raise awareness diagnostic "red flags" associated with cardiac currently available non-invasive strategies diagnosis. focuses on identification one two main types amyloidosis, transthyretin amyloid cardiomyopathy, tools distinguish from light-chain amyloidosis. A algorithm centered around use imaging laboratory analysis...
Planar and single-photon emission computed tomography (SPECT) nuclear imaging techniques with bone seeking radiotracers have been increasingly adopted for diagnosis of ATTR cardiac amyloidosis. However, inherent limitations these due to lack anatomical landmarks recognized, consequent high numbers equivocal or false positive cases. SPECT/computed (CT) fusion offers a significant advantage overcome by substantially reducing inaccurate interpretations. The authors present the results 3-year...
Aesop's fable of the wolf in sheep's clothing encourages us to look beneath exterior appearance a situation and evaluate truth that lies beneath. This concept should be applied when managing older patients with severe aortic stenosis. population is increasingly being identified as having concomitant cardiac amyloidosis, which an underrecognized cause common conditions. The presence amyloidosis negatively affects outcome stenosis, these undergo transcatheter valve replacement (TAVR)...
Background: Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder which leads to progressive muscle degeneration and weakness. Most patients die from cardiac or respiratory failure. Gene transfer therapy offers promising approach treating this disorder. Objective: Given the genetic disease burden, family size, high consanguinity rates in Middle East, our objective address current practices challenges of DMD patient care within two countries region, namely United Arab Emirates...
Abstract Glioblastoma is immunologically “cold” and resistant to single-agent immune-checkpoint inhibitors (ICI). Our previous study of neoadjuvant pembrolizumab in surgically-accessible recurrent glioblastoma identified a molecular signature response ICI suggested that may improve survival. To increase the power this observation, we performed bulk-RNA seq on resected tumor tissue from an additional 25 patients with treated pembrolizumab. Neoadjuvant was associated suppression cell...
Abstract: These proceedings from the First Gulf Cardiac Amyloidosis Summit held in June 2021 aimed to increase awareness of cardiac amyloidosis among wider medical community region. Although clinical presentation is highly variable, a number ‘red flags’ have been identified raise suspicion disease and prompt further investigation. Accurate diagnosis challenging relies on integration clinical, imaging laboratory investigations. Recent techniques, including bone scintigraphy together with...