A5102717612- Retinal Development and Disorders
- Cancer-related Molecular Pathways
- Ocular Oncology and Treatments
- Photoreceptor and optogenetics research
- Nutritional Studies and Diet
- Neuroscience and Neural Engineering
- Body Composition Measurement Techniques
- Nutrition and Health in Aging
Anhui Medical University
2024
Affiliated Eye Hospital of Wenzhou Medical College
2020
Wenzhou Medical University
2019-2020
State Key Laboratory of Ophthalmology
2020
Significance As a genetic malignancy, retinoblastoma (Rb) is caused by RB1 mutations; however, its developmental origin and drug agents for human Rb remain largely unexplored. Here we describe an innovative organoid model derived from embryonic stem cells with biallelic mutagenesis of the gene. We identify tumorigenic growth in organoids, as well properties consistent primary Rb. confirm that cell stemmed ARR3 + maturing cone precursor SYK inhibitors displaying significant therapeutic...
Although an increasing number of disease genes have been identified, the exact cellular mechanisms retinitis pigmentosa (RP) remain largely unclear. Retinal organoids (ROs) derived from induced pluripotent stem cells (iPSCs) patients provide a potential but unvalidated platform for deciphering and advantageous tool preclinical testing new treatments. Notably, early-onset RP has extensively recapitulated by patient-iPSC-derived ROs. However, it remains challenge to model late-onset in dish...
Retinoblastoma (Rb) is the most prevalent intraocular malignant tumour in children with survival rate less than 30% globally. Its developmental origin and drug agents remain largely unexplored. Here, we developed first organoid Rb model derived from human embryonic stem cells (hESCs) a biallelic knockout (RB1-/-) or mutagenesis (RB1Mut/Mut). These retinoblastomas exhibit extremely consistent properties of tumourigenesis, transcriptome, genome-wide methylation. We found originated ARR3+...