A5010426630- Chronic Obstructive Pulmonary Disease (COPD) Research
- Chronic Disease Management Strategies
- Health disparities and outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Delphi Technique in Research
- Nutrition and Health in Aging
- Healthcare cost, quality, practices
- Global Health Care Issues
- Smoking Behavior and Cessation
- Nanowire Synthesis and Applications
- Diverse Legal and Medical Studies
- Clinical practice guidelines implementation
- Neurological Disorders and Treatments
- Semiconductor Quantum Structures and Devices
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neurological Disease Mechanisms and Treatments
- Cardiovascular and exercise physiology
- Respiratory Support and Mechanisms
- Health, psychology, and well-being
- Brain Tumor Detection and Classification
- Health Policy Implementation Science
- Total Knee Arthroplasty Outcomes
- Dysphagia Assessment and Management
University of Basel
2024
Helmholtz Zentrum München
2015-2021
German Center for Lung Research
2015-2018
Siemens (Germany)
1992-2008
Machine-learning classifiers mostly offer good predictive performance and are increasingly used to support shared decision-making in clinical practice. Focusing on practicability, this study evaluates prediction of patient-reported outcomes (PROs) by eight supervised including a linear model, following hip knee replacement surgery.NHS PRO data (130,945 observations) from April 2015 2017 were train test predict binary postoperative improvement based minimal important differences. Area under...
The EQ-5D-5L is a widely used generic instrument to measure health-related quality of life. This study evaluates health perception in representative sample the general German population from 2015. To compare results over time, component analysis technique was that separates changes description and valuation states. whole also subgroups, stratified by sociodemographic parameters as well disease affliction, were analyzed. In total, 2040 questionnaires (48.4% male, mean age 47.3 year) included....
Health-related quality of life (HRQoL) is a key measure for evaluating health status in populations. Using the recent EQ-5D-5L measurement, this study analyzed results and their stability over consecutive population surveys. Three cross-section surveys representative samples general German from 2012, 2013, 2014 were evaluated using descriptive system valuation by Visual Analog Scale (VAS). Aggregated sample size reached 6074. The dimension with highest prevalence problems was pain/discomfort...
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an unexplained chronic, debilitating illness characterized by fatigue, sleep disturbances, cognitive dysfunction, orthostatic intolerance and gastrointestinal problems. Using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), we analyzed the plasma proteomes of 39 ME/CFS patients 41 healthy controls. Logistic regression models, with both linear quadratic terms protein levels as independent variables,...
Evidence on the economic impact of chronic obstructive pulmonary disease (COPD) for third-party payers and society based large real world datasets are still scarce. Therefore, aim this study was to estimate COPD severity its comorbidities, stratified by GOLD grade, direct indirect costs an unselected population enrolled in structured German Disease Management Program (DMP) COPD.All individuals DMP were included analysis. Patients only excluded if they not insured or complete year before last...
Body mass index (BMI) is an important parameter associated with mortality and health-related quality of life (HRQoL) in chronic obstructive pulmonary disease (COPD). However, informed guidance on stratified weight recommendations for COPD still lacking. This study aims to determine the association between BMI HRQoL across different severity grades support patient management.
Population-based value sets are widely used to transform health states into utilities, but may deviate from actual patient experience. Whether this occurs in a systematic way can be analyzed, first step, for respondents who do not report problems on the five domains of EQ-5D-5L instrument population studies.EQ-5D-5L results three annual cross-sectional surveys (2012, 2013, and 2014) were filtered participants reported being problem-free. Continuous visual analog scale (VAS) scores, ranging 0...
Abstract Aims To evaluate potential health and economic returns from implementing smoking cessation interventions in Hungary. Methods The EQUIPTMOD, a Markov‐based model, was used to assess the cost‐effectiveness of three implementation scenarios: (a) introducing social marketing campaign; (b) doubling reach existing group‐based behavioural support therapies proactive telephone support; (c) combination two scenarios. All scenarios were compared with current practice. chosen as feasible...
Abstract Aims To evaluate costs, effects and cost‐effectiveness of increased reach specific smoking cessation interventions in Germany. Design A Markov‐based state transition return on investment model (EQUIPTMOD) was used to current as well two prospective scenarios. health‐care perspective (extended include out‐of‐pocket payments) with life‐time horizon considered. probabilistic analysis assess uncertainty concerning predicted estimates. Setting Participants Cohort population (18+ years)...
Little is known about how long-term weight gain affects the health perception of COPD patients. The aim to evaluate association BMI change and health-related quality life (HRQoL) in obese Claims survey data from a disease management program were used match two groups patients with ≥ 30 who have differing trajectories over 5-year timespan via propensity score genetic matching. EQ-5D-5L, including visual analog scale (VAS) Assessment Test (CAT), as outcomes interest. Sociodemographic...
Evidence indicates that sphingolipid accumulation drives complex molecular alterations promoting cardiometabolic diseases. Clinically, it was shown sphingolipids predict risk independently of and beyond traditional biomarkers such as low-density lipoprotein cholesterol. To date, little is known about therapeutic modalities to lower levels. Exercise, a powerful means prevent treat diseases, promising modality mitigate levels in cost-effective, safe, patient-empowering manner.
Pat. mit COPD IV nach GOLD und Komorbiditäten entwickeln psychosomatische Störungen die zu einer eingeschränkten Krankheitsbewältigung sozialen Integration führen eine hohe gesundheitspolitische Bedeutung haben.
<b>Background:</b> Guidelines for COPD suggest treatment according to the ABCD classification system, which measures symptom burden and risk of exacerbations. Symptom can be assessed via assessment test (CAT) or modified British Medical Research Council (mMRC) scale. Exacerbation might self-reported ambulatory/hospital documented. Evidence if different methods deliver congruent results is sparse. <b>Methods:</b> We CAT, mMRC exacerbations from participants a disease management program German...