In this review, we survey the diversity of structures and functions which are encountered in advanced self-assembled nanomaterials. We highlight their flourishing implementations three active domains applications: biomedical sciences, information technologies, environmental sciences. Our main objective is to provide reader with a concise straightforward entry broad field by selecting most recent important research articles, supported some more comprehensive reviews introduce each topic....

Dynamic glycopolymers have been generated by polycondensation through acylhydrazone formation between components bearing lateral bioactive oligosaccharide chains. They characterized as bottlebrush type cryo-TEM and SANS studies. present remarkable fluorescence properties whose emission wavelengths depend on the constitution of polymer are tunable constitutional modification exchange/incorporation components, thus also demonstrating their dynamic character. Constitution-dependent binding...

A change in the constitution: Dynamic glycopolymers based on a poly(acylhydrazone) main chain bearing lateral oligosaccharide groups have been obtained and their structure has characterized as bottlebrush type (see picture) by cryo-TEM small-angle neutron scattering studies. They remarkable fluorescence with emission wavelengths which are tunable exchange/incorporation of components modify polymer constitution. Supporting information for this article is available WWW under...

Self-assembled peptide amphiphiles (PAs) consisting of hydrophobic, hydvrogen-bonding, and charged hydrophilic domains form cylindrical nanofibers in physiological conditions allow for the presentation a high density bioactive epitopes on nanofiber surface. We report here use PAs to multifunctional nanostructures with tumoricidal activity. The combination cationic, membrane-lytic PA coassembled serum-protective, pegylated was shown self-assemble into nanofibers. Addition nanostructure...

We report here the preparation of filamentous virus-like particles by encapsulation a linear or circular double-stranded DNA template with preassembled mushroom-shaped nanostructures having positively charged domain. These mimic capsid proteins natural viruses and are formed self-assembly coiled-coil peptides conjugated at opposite termini cationic segments poly(ethylene glycol) (PEG) chains. found that high molecular weight PEG was critical for formation monodisperse uniformly shaped...

The broad interest of using reversible covalent bonds in chemistry, particular at its interfaces with biology and materials science, has been recently established through numerous examples the literature. However, challenging exchange peptide fragments a dynamic bond not yet achieved without enzymatic catalysis because high thermodynamic stability. Here we show that can be exchanged by chemoselective native chemical ligation (NCL) which take place N-(methyl)-cysteine residues. This very mild...

The use of DNA-encoded libraries has emerged as a powerful hit generation technology. Combining the power combinatorial chemistry to enumerate large compound collections with efficiency affinity selection in pools, methodology makes it possible interrogate vast chemical space against biological targets pharmaceutical relevance. Thus, transformations employed for synthesis encoded play crucial role identification diverse and drug-like starting points. Currently established have mostly been...

Dynamic mixtures obtained by reversible covalent acylhydrazone formation of fragrance aldehydes and/or ketones and a hydrazide in water were found to be efficient delivery systems for the controlled release highly volatile organic molecules.

Herein, we describe the development of copper-catalyzed cross-coupling DNA-conjugated aryl iodides with aliphatic amines. This protocol leverages a novel ligand, 2-((2,6-dimethoxyphenyl)amino)-2-oxoacetic acid, to effect transformation in aqueous DMSO, under mild conditions and air, making it an ideal candidate for synthesis DNA-encoded libraries.

Progresses in spatial and temporal analytical tools open new avenues for the study control of increasingly complex chemical systems.

Dynamic analogs of alpha-(1-->5)-D-oligoarabinofuranosides were prepared by oxime polycondensation. These equilibrium polymers characterized (1)H NMR studies, DOSY, and MALDI mass spectrometry. Their reversibility under mild acidic conditions was demonstrated component exchange reaction followed studies. size composition can be tuned emphasizing their constitutionally dynamic character. They represent versions biopolymers, biodynamers.

The development of tumor-targeted nanoscale carriers for the delivery cancer therapeutics offers ability to increase efficacy while limiting off-target toxicity. In this work, we focused on targeting death receptor 5 (DR5), which is highly expressed by cells and, upon binding, triggers programmed cell death. Hence, a nanostructure DR5 would act as dual and therapeutic agent. We report here peptide amphiphile (PA) containing dimeric, cyclic that self-assembles into cylindrical supramolecular...

Eingriffe in die Konstitution: Dynamische Glycopolymere mit einer Poly(acylhydrazon)-Hauptkette und Oligosaccharid-Seitengruppen haben laut Kryo-TEM- Kleinwinkelneutronenstreuexperimenten eine Bürstenstruktur (siehe Bild). Die Fluoreszenz-Emissionswellenlängen lassen sich durch Austausch oder Einbau von Komponenten einstellen, Polymerkonstitution verändern. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2008/z703490_s.pdf or...

Herein, we describe the development of a practical catch-and release methodology utilizing cationic, amphiphilic PEG-based polymer to perform chemical transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate usefulness our APTAC (<u>a</u>mphiphilic <u>p</u>olymer-facilitated <u>t</u>ransformations <u>a</u>nhydrous <u>c</u>onditions) approach by performing several challenging DNA-conjugated small...

Herein, we describe the development of a practical catch-and release methodology utilizing cationic, amphiphilic PEG-based polymer to perform chemical transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate usefulness our APTAC ( mphiphilic p olymer-facilitated t ransformations nhydrous c onditions) approach by performing several challenging DNA-conjugated small molecules in pure organic solvents: addition carbanion equivalent ketone tetrahydrofuran,...

Herein, we describe the development of a practical catch-and release methodology utilizing cationic, amphiphilic PEG-based polymer to perform chemical transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate usefulness our APTAC ( mphiphilic p olymer-facilitated t ransformations nhydrous c onditions) approach by performing several challenging DNA-conjugated small molecules in pure organic solvents: addition carbanion equivalent ketone tetrahydrofuran,...

Herein, we describe the development of a practical catch-and release methodology utilizing cationic, amphiphilic PEG-based polymer to perform chemical transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate usefulness our APTAC ( mphiphilic p olymer-facilitated t ransformations nhydrous c onditions) approach by performing several challenging DNA-conjugated small molecules in pure organic solvents: addition carbanion equivalent ketone tetrahydrofuran,...

Abstract Review: [72 refs.

Herein, we describe the development of a practical catch-and release methodology utilizing cationic, amphiphilic PEG-based polymer to perform chemical transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate usefulness our ATAC ( mphiphilic polymers for t ransformations nhydrous c onditions) approach by performing several challenging DNA-conjugated small molecules in pure organic solvents: addition carbanion equivalent ketone tetrahydrofuran, synthesis...

Herein, we describe the development of a practical catch-and release methodology utilizing cationic, amphiphilic PEG-based polymer to perform chemical transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate usefulness our APTAC ( mphiphilic p olymer-facilitated t ransformations nhydrous c onditions) approach by performing several challenging DNA-conjugated small molecules in pure organic solvents: addition carbanion equivalent ketone tetrahydrofuran,...