A5061501399- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Respiratory viral infections research
- Liver Disease and Transplantation
- Genetic Associations and Epidemiology
- Agricultural Economics and Practices
- Tracheal and airway disorders
- Social and Economic Development in India
- Vitamin D Research Studies
- Animal Virus Infections Studies
- HIV Research and Treatment
- Neonatal Respiratory Health Research
- Genomics and Rare Diseases
- Evolution and Genetic Dynamics
- Global Health and Epidemiology
- Plant Reproductive Biology
- BRCA gene mutations in cancer
- Monoclonal and Polyclonal Antibodies Research
- Viral gastroenteritis research and epidemiology
- RNA and protein synthesis mechanisms
- Nutrition, Genetics, and Disease
- Vaccine Coverage and Hesitancy
- Systemic Lupus Erythematosus Research
National Science and Technology Development Agency
2019-2025
National Center for Genetic Engineering and Biotechnology
2020-2024
Chulalongkorn University
2015-2023
Thai Red Cross Society
2016
Hepatitis B vaccination for newborns was introduced in two provinces 1988 as part of Thailand's Expanded Program on Immunization (EPI), and extended to the whole country 1992. Our previous studies showed that children adolescents who were born after implementation this program had a carrier rate less than 1%, compared with 5-6% before implementation. In 2014 we performed hepatitis serosurveys among 5964 subjects different geographic regions evaluate long-term immunogenicity impact universal...
The majority of hepatitis C virus (HCV) infection results in chronic infection, which can lead to liver cirrhosis and hepatocellular carcinoma. Global burden is estimated at 150 million individuals, or 3% the world's population. distribution seven major genotypes HCV varies with geographical regions. Since Asia has a high incidence HCV, we assessed Thailand Southeast Asia. From 588 HCV-positive samples obtained throughout Thailand, characterized 5' untranslated region, Core, NS5B regions by...
Hepatitis C virus (HCV) infection affects ≥ 180 million individuals worldwide especially those living in developing countries. Recent advances direct-acting therapeutics promise effective treatments for chronic HCV carriers, but only if the affected are identified. Good treatment coverage therefore requires accurate epidemiological data on infection. In 2014, we determined current prevalence of Thailand to assess whether over past decade significant number carriers had changed. total, 5964...
To maximize the potential of genomics in medicine, it is essential to establish databases genomic variants for ethno-geographic groups that can be used filtering and prioritizing candidate pathogenic variants. Populations with non-European ancestry are poorly represented among current variant databases. Here, we report first high-density survey Thai population, Reference Exome (T-REx) database. T-REx comprises exome sequencing data 1092 unrelated individuals. The targeted regions common four...
<title>Abstract</title> Type 2 diabetes (T2D) is a heterogeneous disease that can be distinguished at newly diagnosis by variations in clinical presentation, trajectory, therapeutic response, and risk of complications. Its global prevalence increasing, particularly among Asian populations such as Thais, due to unique genetic environmental factors. Thai patients with diagnosed T2D have been classified into four clusters based on standard parameters. However, the polygenic basis underlying...
Type 2 diabetes is a heterogeneous disease with strong genetic components. We showed earlier that newly diagnosed type in Thai patients could be categorized into four clusters. This study aimed to determine the evidence of hereditary factors these A total 487 subjects who were two years enrolled Siriraj Diabetes Center, Hospital Bangkok, Thailand. They divided clusters as previously described. The associations between patients' characteristics, degree family history (FHD), and tested using...
Respiratory syncytial virus (RSV) causes acute lower respiratory tract infection in infants and young children worldwide. To investigate the RSV burden Thailand over four consecutive years (January 2012 to December 2015), we screened 3,306 samples obtained from ≤5 old with using semi-nested reverse-transcription polymerase chain reaction (RT-PCR). In all, 8.4% (277/3,306) of specimens tested positive for RSV, most which appeared rainy months July November. We then genotyped by sequencing G...
The core antigen of the hepatitis C virus (HCV Ag) presents an alternative marker to HCV RNA when screening patients for viremia. This study sought evaluate utility Ag as a assess active infection in individuals residing HCV-endemic area. From 298 HCV-seropositive evaluated presence anti-HCV antibody, and RNA, antibody was detected 252 (signal-to-cutoff ratios ≥5), 222 (88%), reactive (≥3 fmol/L) 220 (87%). genotype 1, 3, 6 were identified. significantly correlated with irrespective and/or...
Improved awareness of the hepatitis C virus (HCV) transmission has contributed to overall decline in HCV infection rate some developing countries including Thailand. Chronic rural Thai communities, however, presents a challenge efforts treat and manage HCV-related diseases. Published unpublished studies have suggested an unusually high incidence province Phetchabun compared elsewhere To determine magnitude identify potential factors contributing higher this province, we performed...
BACKGROUND Hepatitis E virus (HEV) infection in several industrialized and developing countries is associated with the consumption of pork other meat products, an exposure risk among majority blood donors. We aimed to evaluate prevalence HEV plasma from healthy donors Thailand. STUDY DESIGN AND METHODS screened samples collected between October December 2015, 30,115 individual 5020 pools six, for RNA using in‐house real‐time reverse‐transcription polymerase chain reaction (RT‐PCR)....
Chronic hepatitis C virus (HCV) infection can lead to liver cirrhosis and hepatocellular carcinoma. To eliminate HCV in an endemic area, epidemiological baseline of the current population is required. We therefore aimed evaluate burden Thai Province Phetchabun, which has highest rate country. Toward this, a province-wide district-based representative sampling 4,769 individuals ages 35–64 years previously shown represent high-risk age-groups were tested for anti-HCV antibodies using automated...
Hepatitis A virus (HAV) and hepatitis E (HEV) infection in developing countries are associated with contaminated food or water. Although Thailand is non-endemic for HEV, sporadic infections may occur from zoonotic transmission. Individuals between 7 months to 69 years (mean age = 32.8) predominantly Islamic Narathiwat (n 305) swine farm-dense Lop Buri 416) provinces were screened anti-HEV anti-HAV antibodies by commercial enzyme-linked immunosorbent assay automated chemiluminescent...
The prevalence of hepatitis C virus (HCV) infection has been decreasing globally, but the growing effects HCV-related morbidity and mortality remain concern. Advances in curative medicine, involving direct-acting antivirals (DAAs), have led many countries to aim eradicate HCV. Information on epidemiology disease burden is essential for national policy development. Thus, this study aimed determine hepatic areas Thailand with high average HCV order extrapolate viral across Thailand. Patients...
Universal hepatitis B (HB) vaccination among Thai newborns was initiated in 1992. The first dose of the monovalent HB vaccine given at birth, then months 2 and 6 simultaneously with diphtheria-tetanus-pertussis whole-cell (DTPw) vaccine. In 2008, Thailand replaced a combined DTP-HB 2, 4, 6, an added month 1 for infants whose mothers were HBV carriers. Despite this rigorous schedule, vaccinated who are now adolescents do not possess protective level anti-HB surface antigen (anti-HBs) (≥10...
Measles and rubella are highly contagious viral diseases transmitted via respiratory secretions aerosolized droplets. Thailand has implemented universal vaccination against measles using the monovalent (M) or trivalent measles-mumps-rubella (MMR) vaccine for past 30 years. Nevertheless, incidence of remains in some parts country. We conducted a seroprevalence study to evaluate antibodies virus among Thais all ages determine pre-existing immunity resulting from either and/or natural exposure....
Hepatitis A (HAV), hepatitis B (HBV), and C (HCV) viruses are hepatotropic responsible for acute/chronic associated with liver failure, cirrhosis, hepatocellular carcinoma. Due to the limited data on prevalence of in older population Thailand, this study aimed evaluate seroprevalence these elderly Thais. Using an automated immunoassay, serum samples from individuals than 60 years age Chum Phae district Khon Kaen province northeast Thailand were analyzed anti-HAV ( n = 93), HBV markers 460,...
The World Health Organization envisions the elimination of viral hepatitis by 2030 through reducing prevalence and transmission, increasing diagnostic screening, expanding treatment coverage. Efforts to micro-eliminate in Phetchabun province Thailand, a region where C virus (HCV) infection liver cancer is higher than elsewhere country, began with evaluating province-wide burden HCV. Here, we describe feasibility study assess active HCV screening residents ages 35 69 years for anti-HCV...
The single nucleotide polymorphism (SNP) ss469415590 in the interferon lambda-4 (IFNL4) gene has recently been reported to have an association with treatment response chronic hepatitis C. However, any importance of SNP pegylated (PEG-IFN) therapy patients B (CHB) is unclear. We retrospectively analyzed data for Thai CHB treated PEG-IFN 48 weeks. Virological (VR) HBeAg-positive was defined as HBeAg seroconversion plus HBV DNA level <2,000 IU/mL at 24 weeks post-treatment. VR HBeAg-negative...
Hepatitis C virus (HCV) infection is an important worldwide public health problem, and most of the global HCV burden in low- to middle-income countries. This study aimed estimate future chronic hepatitis (CHC) impact policies using novel antiviral agents Thailand. A mathematical model CHC transmission dynamics was constructed examine disease over next 20 years different treatment strategies. We compared evaluated current (PEGylated interferon ribavirin) with new treatments direct-acting...
Patients with chronic hepatitis C (HCV) infection have high prevalence of vitamin D deficiency. Genome-wide association study data has showed that several genetic variants within cascade affect function. This aimed to determine whether polymorphisms genes in the pathway are associated treatment responses pegylated interferon (PEG-IFN)-based therapy patients HCV infection. The included 623 Thai from 2 university hospitals diagnosed who were treated a PEG-IFN and ribavirin. genotyped for...
The complexity of the hepatitis C virus (HCV) diagnostic workflow and stringent criteria for universal health coverage are significant barriers to achieving HCV elimination in Thailand. A test-to-treat strategy using a rapid test (RDT) screening at point care, followed by qualitative nucleic acid testing, is promising facilitate population-wide infection expedite time treatment. This was evaluated Phetchabun province, Thailand, where burden relatively high. simplified showed strong potential...
The World Health Organization aims to eliminate HCV infection worldwide by 2030. A targeted screening policy is currently unavailable in Thailand, but a decrease has been observed the country. However, previous study showed that there was higher seroprevalence adults aged between 30-64 years Phetchabun province (15.5%), as compared Khon Kaen (3.6%). It hypothesized young had lower rate of seropositivity; this determined age distribution anti-HCV and with identification high birth cohorts. In...
Interferon-gamma inducible protein 10 (IP-10) plays an important role in the clinical outcome of chronic hepatitis B (CHB). This study aimed to investigate association between single nucleotide polymorphisms (SNPs) G-201A IP-10 gene and treatment response pegylated interferon (PEG-IFN) patients with e antigen (HBeAg)-positive CHB.We retrospectively analysed data HBeAg-positive CHB treated PEG-IFN for 48 weeks. Virological (VR) was defined as HBeAg clearance HBV DNA <2,000 IU/ml at 24 weeks...
Vitamin D receptor (VDR) modulates host immune responses to infections such as hepatitis C virus (HCV) infection, including interferon signaling. This study aimed investigate the associations of VDR polymorphisms with advanced liver fibrosis and response pegylated (PEG-IFN)-based therapy in patients chronic HCV infection. In total, 554 Thai infection treated a PEG-IFN-based regimen were enrolled. Six single-nucleotide (SNPs) genotyped: IL28B > T (rs12979860) SNP five SNPs, comprising FokI...