A5082315786- melanin and skin pigmentation
- Biochemical Analysis and Sensing Techniques
- Phytochemicals and Antioxidant Activities
- Skin Protection and Aging
- Free Radicals and Antioxidants
- Olfactory and Sensory Function Studies
- Dyeing and Modifying Textile Fibers
- Photochromic and Fluorescence Chemistry
- Synthesis of Organic Compounds
- Antioxidant Activity and Oxidative Stress
- Nitric Oxide and Endothelin Effects
- Bioactive Compounds and Antitumor Agents
- Oxidative Organic Chemistry Reactions
- Radical Photochemical Reactions
- Polymer Surface Interaction Studies
- Dye analysis and toxicity
- Pomegranate: compositions and health benefits
- Conducting polymers and applications
- Synthesis and Biological Evaluation
- Molecular Sensors and Ion Detection
- Chemical Reaction Mechanisms
- Nanocomposite Films for Food Packaging
- biodegradable polymer synthesis and properties
- Photochemistry and Electron Transfer Studies
- Synthesis of Indole Derivatives
University of Naples Federico II
2015-2024
University of Rome Tor Vergata
2023
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2015-2020
Naples Anesthesia & Physician Associates
2015-2018
University of Florence
2015
Scuola Normale Superiore
2010-2013
University of Bologna
2013
Keele University
2006-2010
University of Salford
2006-2009
University of Manchester
2009
ConspectusPolydopamine (PDA), a black insoluble biopolymer produced by autoxidation of the catecholamine neurotransmitter dopamine (DA), and synthetic eumelanin polymers modeled to functional pigments human skin, hair, eyes have burst into scene materials science as versatile bioinspired systems for very broad range applications. PDA is characterized extraordinary adhesion properties providing efficient universal surface coating diverse settings that include drug delivery, microfluidic...
Abstract Rational approaches to engineering polydopamine films with tailored properties for surface coating and functionalization are currently challenged by the lack of detailed information about polymer structure mechanism buildup. Using an integrated chemical spectroscopic approach enables demonstration of: a) a three‐component polydopamine, comprising uncyclized (catecholamine) cyclized (indole) units, as well novel pyrrolecarboxylic acid moieties; b) remarkable variations in relative...
The black we wear: Why nature selected 5,6-dihydroxyindole-2-carboxylic acid (DHICA) to synthesize (photo)protective eumelanin pigments is an enigma. Synthetic DHICA has now been shown be a highly efficient free-radical scavenger in the solid state, which due conformationally interrupted π-electron network associated with atypical optical, paramagnetic, and aggregation properties.
Despite the growing technological interest of polydopamine (dopamine melanin)-based coatings for a broad variety applications, factors governing particle size, shape, and electronic properties this bioinspired multifunctional material have remained little understood. Herein, we report detailed characterization growth, morphology, paramagnetic as function dopamine concentration nature buffer (pH 8.5). Dynamic Light Scattering data revealed an increase in hydrodynamic radii (Rh) melanin...
One of the most common approaches for control skin pigmentation involves inhibition tyrosinase, a copper-containing enzyme which catalyzes key steps melanogenesis. This review focuses on tyrosinase properties series natural and synthetic, bioinspired phenolic compounds that have appeared in literature last five years. Both mushroom human inhibitors been considered. Among first class, flavonoids, particular chalcones, occupy prominent role as inhibitors, followed by hydroxystilbenes (mainly...
A fundamental unsettled issue concerning eumelanins, the functional biopolymers of human skin and hair, is why they are black. The experimental difficulty lies in virtual insolubility these pigments, causing marked scattering effects hindering characterization intrinsic absorption properties heterogeneous species produced by oxidative polymerization 5,6-dihydroxyindole (DHI) related monomer precursors. synthesis spectrally robust, water-soluble DHI polymers therefore an important goal...
The role of 5,6-dihydroxyindole (DHI)-based oligomers, including porphyrin-like tetramers, in polydopamine (PDA) film formation was addressed by a comparative structural investigation against model polymers from DHI and its 2,7′-dimer. MALDI-MS data showed that (a) PDA is structurally different melanin does not contain species compatible with DHI-based oligomers as primary building blocks; (b) films precipitate display single main peak at m/z 402 common; (c) no matching the range values...
Summary The highest incidence of melanoma in red haired individuals is attributed to the synthesis and phototoxic properties pheomelanin pigments. Recently, has also been implicated UV ‐independent pathways oxidative stress; however, underlying mechanisms have remained uncharted. Herein, we disclose unprecedented property purified human hair ( RHP ) promote (i) oxygen‐dependent depletion major cell antioxidants, for example glutathione NADH ; (ii) autoxidative formation melanin pigments from...
Despite extensive investigations over the past decade, chemical basis of extraordinary underwater adhesion properties polydopamine (PDA) has remained not entirely understood. The bulk evidence points to PDA wet as a complex process based on film deposition, and growth in which primary amine groups, besides catechol moieties, play central role. However, detailed interplay interactions underlying dynamics formation yet been elucidated. Herein, we report results series experiments showing that...
Eumelanins, the chief photoprotective pigments in man and mammals, owe their black color to an unusual broadband absorption spectrum whose origin is still a conundrum. Excitonic effects from interplay of geometric order disorder 5,6-dihydroxyindole (DHI)-based oligomeric/polymeric structures play central role, however contributions structural (scaffold-controlled) redox (π-electron-controlled) have remained uncharted. Herein, we report integrated experimental-theoretical entry eumelanin...