A5017025256- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Herpesvirus Infections and Treatments
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Immune responses and vaccinations
- Gut microbiota and health
- Immunotherapy and Immune Responses
Oregon National Primate Research Center
2021-2022
Oregon Health & Science University
2021-2022
Abstract In the absence of a prophylactic vaccine, use antiretroviral therapy (ART) as pre-exposure prophylaxis (PrEP) to prevent HIV acquisition by uninfected individuals is promising approach slowing epidemic, but its efficacy hampered incomplete patient adherence and ART-resistant variants. Here, we report that competitive inhibition Env-CCR5 binding via CCR5-specific antibody Leronlimab protects rhesus macaques against infection following repeated intrarectal challenges CCR5-tropic SHIV...
The CCR5-specific antibody Leronlimab is being investigated as a novel immunotherapy that can suppress HIV replication with minimal side effects. Here we studied the virological and immunological consequences of in chronically CCR5-tropic HIV-1 infected humans (n = 5) on suppressive antiretroviral therapy (ART) ART-naïve acutely SHIV rhesus macaques 4). All five human participants transitioned from daily combination ART to self-administered weekly subcutaneous (SC) injections 350 mg or 700...
Here, we assessed the efficacy of a short-course multimodal therapy (enrofloxacin, azithromycin, fenbendazole, and paromomycin) to eliminate common macaque endemic pathogens (EPs) evaluated its impact on gastrointestinal (GI) microbiota, mucosal integrity, local systemic inflammation in sixteen clinically healthy macaques. Treatment combined with expanded practices resulted successful maintenance rhesus macaques (RM) free EPs, no evidence overt microbiota diversity loss or dysbiosis instead...
Abstract Background Identification of lymph nodes (LNs) draining a specific site or in obese macaques can be challenging. Methods Indocyanine Green (ICG) was administered intradermal (ID), intramuscular, the oral mucosa, subserosal colon followed by Near Infrared (NIR) imaging. Results After optimization to maximize LN identification, ICG successful identifying 50–100% axillary/inguinal at site. Using NIR, collection peripheral and mesenteric LNs 100% after traditional methods failed....