Stephen Bondoc
A5069371183- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- SARS-CoV-2 detection and testing
- Dermatological and COVID-19 studies
- interferon and immune responses
- Long-Term Effects of COVID-19
- Inflammasome and immune disorders
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Immune responses and vaccinations
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- HIV/AIDS drug development and treatment
- Herpesvirus Infections and Treatments
Oregon Health & Science University
2020-2023
Vaccine and Gene Therapy Institute
2022
Children's Cancer Therapy Development Institute
2021-2022
Oregon National Primate Research Center
2021
Abstract Coronavirus disease 2019 (COVID-19) in humans is often a clinically mild illness, but some individuals develop severe pneumonia, respiratory failure and death 1–4 . Studies of acute syndrome coronavirus 2 (SARS-CoV-2) infection hamsters 5–7 nonhuman primates 8–10 have generally reported clinical disease, preclinical SARS-CoV-2 vaccine studies demonstrated reduction viral replication the upper lower tracts 11–13 Here we show that high-dose intranasal results including high levels...
HIV-associated neurocognitive disorders (HAND) affect ~40% of virally suppressed people with HIV (PWH), however, the precise viral dependent and independent changes to brain are unclear. Here we characterized CNS reservoir immune environment SIV-infected (SIV+) rhesus macaques during acute (n = 4), chronic 12) or ART-suppressed SIV infection 11). Multiplex immunofluorescence for markers (vRNA/vDNA) activation was performed on frontal cortex matched colon tissue. SIV+ animals contained...
Here, we assessed the efficacy of a short-course multimodal therapy (enrofloxacin, azithromycin, fenbendazole, and paromomycin) to eliminate common macaque endemic pathogens (EPs) evaluated its impact on gastrointestinal (GI) microbiota, mucosal integrity, local systemic inflammation in sixteen clinically healthy macaques. Treatment combined with expanded practices resulted successful maintenance rhesus macaques (RM) free EPs, no evidence overt microbiota diversity loss or dysbiosis instead...
Syrian golden hamsters exhibit features of severe disease after SARS-CoV-2 WA1/2020 challenge and are therefore useful models COVID-19 pathogenesis prevention with vaccines. Recent studies have shown that infection stimulates type I interferon, myeloid, inflammatory signatures similar to human weight loss can be prevented However, the impact vaccination on transcriptional programs associated protective adaptive immune responses is unknown. Here we show in myeloid as well complement...
Abstract Background To compare the effects of first-line antiretroviral therapy (ART) with dolutegravir plus lamivudine (DTG + 3TC) versus emtricitabine/tenofovir alafenamide FTC/TAF) on human immunodeficiency virus type 1 (HIV-1) reservoir and immune activation biomarkers in people HIV (PWH). Methods DUALITY was a 48-week, single-center, randomized, open-label clinical trial ART-naive PWH, randomized (1:1) to receive ART DTG 3TC (2DR group) or FTC/TAF (3DR group). We measured total intact...
Abstract Syrian golden hamsters exhibit features of severe disease after SARS-CoV-2 challenge and are therefore useful models COVID-19 pathogenesis prevention with vaccines. Recent studies have shown that infection stimulates type I interferon, myeloid, inflammatory signatures similar to human disease, weight loss can be prevented However, the impact vaccination on transcriptional programs associated protective adaptive immune responses is unknown. Here we show in antiviral, as well...