Vaneesha Ali
A5066507847- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
Bioqual
2020
An urgent global quest for effective therapies to prevent and treat coronavirus disease 2019 (COVID-19) is ongoing. We previously described REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987 REGN10933) that targets nonoverlapping epitopes on the severe acute respiratory syndrome 2 (SARS-CoV-2) spike protein. In this report, we evaluate in vivo efficacy antibody both rhesus macaques, which may model mild disease, golden hamsters, more disease. demonstrate REGN-COV-2 can...
Abstract Coronavirus disease 2019 (COVID-19) in humans is often a clinically mild illness, but some individuals develop severe pneumonia, respiratory failure and death 1–4 . Studies of acute syndrome coronavirus 2 (SARS-CoV-2) infection hamsters 5–7 nonhuman primates 8–10 have generally reported clinical disease, preclinical SARS-CoV-2 vaccine studies demonstrated reduction viral replication the upper lower tracts 11–13 Here we show that high-dose intranasal results including high levels...
Abstract An urgent global quest for effective therapies to prevent and treat COVID-19 disease is ongoing. We previously described REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987+REGN10933) targeting non-overlapping epitopes on the SARS-CoV-2 spike protein. In this report, we evaluate in vivo efficacy antibody both rhesus macaques golden hamsters demonstrate that REGN-COV-2 can greatly reduce virus load lower upper airway decrease induced pathological sequalae when...