A5005674602- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Cutaneous lymphoproliferative disorders research
- Veterinary Oncology Research
- Cell Adhesion Molecules Research
- Skin and Cellular Biology Research
- COVID-19 and healthcare impacts
- SARS-CoV-2 detection and testing
- T-cell and B-cell Immunology
- Autopsy Techniques and Outcomes
- Climate Change and Health Impacts
- Immunotherapy and Immune Responses
- Infectious Diseases and Mycology
- Dermatological and COVID-19 studies
- Autoimmune Bullous Skin Diseases
New England Disabled Sports
2023-2025
Tufts University
2020-2022
An understanding of protective immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for vaccine and public health strategies aimed at ending the global disease 2019 (COVID-19) pandemic. A key unanswered question whether infection with SARS-CoV-2 results in against reexposure. We developed a rhesus macaque model observed that macaques had high viral loads upper lower tract, humoral cellular immune responses, pathologic evidence pneumonia. After initial...
Abstract Coronavirus disease 2019 (COVID-19) in humans is often a clinically mild illness, but some individuals develop severe pneumonia, respiratory failure and death 1–4 . Studies of acute syndrome coronavirus 2 (SARS-CoV-2) infection hamsters 5–7 nonhuman primates 8–10 have generally reported clinical disease, preclinical SARS-CoV-2 vaccine studies demonstrated reduction viral replication the upper lower tracts 11–13 Here we show that high-dose intranasal results including high levels...
Immunity from prior infection or Ad26.COV2.S vaccination protected hamsters challenge with a heterologous strain of SARS-CoV-2 5 weeks later.
To determine the feasibility and safety of ultrasound-guided minimally invasive autopsy in COVID-19 patients. 60 patients who expired between 04/22/2020–05/06/2020 due to were considered for inclusion study, based on availability study staff. Minimally was performed with 14G core biopsies through a 13G coaxial needle. The protocol required 20 cores liver, 30 lung, 12 spleen, heart, kidney, 4 breast, testis, 2 skeletal muscle, fat total 112 per patient. Quality samples evaluated by number,...
Cytotoxic interface dermatitis (CID) is a pattern reaction predominantly at the dermo-epidermal junction that encapsulates numerous chronic non-communicable inflammatory skin conditions in which basal keratinocytes are attacked by T-cell infiltrate leading to apoptosis, lymphocytic satellitosis and vacuolar degeneration. Though many diseases include CID, type of clinical presentation tissue patterns expressed from disease varies. In this study, we evaluate commonalities discrepancies...
Autoimmune skin diseases are complex and thought to arise from a combination of genetics environmental exposures, which trigger an ongoing immune response against self-antigens. Companion animals including cats dogs known develop inflammatory conditions similar humans share the same environment, providing opportunities study spontaneous disease that encompasses genetic factors with One Health approach. A strength comparative immunology approaches is profiles may be assessed across different...
Cutaneous T-cell lymphoma (CTCL) is an uncommon type of involving malignant skin-resident or skin-homing T cells. Canine epitheliotropic (EL) the most common form CTCL in dogs, and it also spontaneously arises from lymphocytes mucosa skin. Clinically, can be difficult to distinguish early-stage CTCLs apart other forms benign interface dermatitis (ID) both dogs people. Our objective was identify novel biomarkers that EL ID, perform comparative transcriptomics human canine EL. Here, we present...
There is a need to standardize pathologic endpoints in animal models of SARS-CoV-2 infection help benchmark study quality, improve cross-institutional comparison data, and assess therapeutic efficacy so that potential drugs vaccines for can rapidly advance. The Syrian hamster model tractable small COVID-19 clinical disease humans. Using the model, authors used traditional assessment with quantitative image analysis outcomes hamsters administered polyclonal immune sera from previously...