A5023603797- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Coronary Artery Anomalies
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Peripheral Artery Disease Management
- Pain Management and Treatment
- Congenital Heart Disease Studies
- Cerebrovascular and Carotid Artery Diseases
- Vascular anomalies and interventions
- Cardiac electrophysiology and arrhythmias
- Kawasaki Disease and Coronary Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac and Coronary Surgery Techniques
- Renal and Vascular Pathologies
- Aortic aneurysm repair treatments
- Cardiovascular Issues in Pregnancy
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Effects of Exercise
Duke University
2014-2025
Charles George VA Medical Center
2012-2022
Rice University
2022
Program Support Center
2018
University of North Carolina at Asheville
2018
United States Department of Veterans Affairs
1989-2014
Virginia Commonwealth University
2000-2013
Hunter Holmes McGuire VA Medical Center
1996-2013
Technion – Israel Institute of Technology
2012
Virginia Commonwealth University Medical Center
1998-2007
Background The lifespan of red blood cells is terminated when macrophages remove senescent by erythrophagocytosis. This puts at the center systemic iron recycling in addition to their functions tissue remodeling and innate immunity. Thus far, erythrophagocytosis has been studied evaluating phagocytosis erythrocytes that were damaged mimic senescence. These studies have demonstrated acquisition some specific individual senescence markers can trigger macrophages, but we hypothesized mechanism...
Summary Platelets, a major constituent of thrombus, play crucial role in the pathogenesis acute ischemic coronary syndromes. The effect ultraviolet laser emission on platelets within thrombi is unknown. effects increasing levels energy whole blood were investigated. Blood samples obtained by aseptic venipuncture and anticoagulated with 3.8% sodium citrate. Samples exposed to increased (0, 30, 45, 60 mJ/mm2; 25 Hz) excimer fluence (308 nm wave-length) then tested for ADP collagen induced...
The broad spectrum of clinical manifestations caused by peripheral arterial disease [PAD] and the morphologic heterogeneity associated atherosclerotic lesions present a considerable management challenge. Endovascular interventions are recognized an effective treatment for PAD. Within this revascularization strategy role atherectomy debulking modalities continue to evolve. Accordingly, study herein assessed efficacy safety novel, solid state, Nd: YAG pulsed-wave [355 nm wavelength] laser in...
Abstract Five patients with significant atherosclerotic lesions of anomalous coronary arteries underwent angiopiasty the vessel. Four had circumflex artery and 1 an right artery. Angiographic clinical success was achieved in all 5 patients. To ensure adequate equipment selection special consideration should be given to angiographic characteristics these vessels, such as orifice configuration, exit angulation, route traverses location stenotic lesions. Major determinants for successful...
In vitro studies during cold pulsed‐wave laser angioplasty have demonstrated production of gas bubbles within the target tissue, creation shock wave and formation multi‐layer dissections accompanied by an increase in plaque vessel wall temperature. These processes account for certain complications coronary lasing, including acute closure, dissections, spasm, even perforation. The traditional lasing technique which a large number pulses is continually emitted across lesion, may fact...
To overcome the adverse complications of balloon angioplasty in thrombus burden lesions (i.e., distal embolization, platelet activation, no-reflow phenomenon with persistent myocardial hypoxemia), mechanical removal or embolization protection devices is required. Pulsed ultraviolet excimer laser light at 308 nm can vaporize and suppress aggregation. Clinical experience has already shown its efficacy acute ischemic-thrombotic coronary syndromes. Unlike other thrombectomy devices, a ablate...
Excimer laser angioplasty is a percutaneous treatment modality for management of selected patients with severe obstructive coronary artery disease. This technology entails application multifiber catheters that vaporize intra-arterial plaque and thrombus the 308-nm wavelength light. A catheter ("OS") increased space between its optic fibers (90 microns) at tip was recently developed. The previous design used closely packed fiber bundle ("CP") smaller (77 microns). We sought to determine...
Patients presenting with acute myocardial infarction who fail to respond standard therapy thrombolytics or have contraindications for their use oftentimes need revascularization a mechanical device removal of an occlusive coronary thrombus and its underlying atherosclerotic plaque. As both thrombi plaques absorb laser energy in the ultraviolet wavelength (308 nm), we studied feasibility safety excimer angioplasty selective patients complicated infarction.Fifty by continuous chest pain and/or...