A5052275932- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Asthma and respiratory diseases
- Mycobacterium research and diagnosis
- Inhalation and Respiratory Drug Delivery
- Sinusitis and nasal conditions
- COVID-19 and Mental Health
- Genomics and Rare Diseases
- Ethics and Legal Issues in Pediatric Healthcare
- Infant Nutrition and Health
- Nosocomial Infections in ICU
- Congenital Heart Disease Studies
- Head and Neck Surgical Oncology
- Prenatal Screening and Diagnostics
- RNA Research and Splicing
- Emergency and Acute Care Studies
- Lipoproteins and Cardiovascular Health
- Family and Patient Care in Intensive Care Units
- Nutrition, Genetics, and Disease
- BRCA gene mutations in cancer
- Antimicrobial Resistance in Staphylococcus
- Assisted Reproductive Technology and Twin Pregnancy
- Bacterial biofilms and quorum sensing
- Family and Disability Support Research
Schneider Children's Hospital
2006-2024
Cohen Children's Medical Center
2015-2024
Northwell Health
2023-2024
Stanford University
2023
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2022
Genomics (United Kingdom)
2016
Saint Vincent's Catholic Medical Center
1999
Stony Brook University
1997
State University of New York
1997
Centre Hospitalier Universitaire de Tours
1997
To identify factors influencing lung dose of aerosolized recombinant human deoxyribonuclease (rhDNase I), we used gamma camera and filter techniques to measure deposition in 15 clinically stable patients with cystic fibrosis (CF) (five males 10 females, age 6-31 yr, mean 16.9) who were on chronic daily therapy. Total regional correlated breathing pattern, pulmonary function, demographic factors, disease severity. In addition, the effects each patient's measured function was estimated by...
Infants are screened for cystic fibrosis (CF) in New York State (NYS) using an IRT-DNA algorithm. The purpose of this study was to validate and assess clinical validity the US FDA-cleared Illumina MiSeqDx CF 139-Variant Assay (139-VA) diverse NYS population. included 439 infants with identified via newborn screening (NBS) from 2002 2012. All had been Abbott Molecular Genotyping or Hologic InPlex Test. zero one mutation were tested 139-VA. DNA extracted dried blood spots reliably accurately...
Little is known about the prevalence of Staphylococcus aureus nasal colonization and epidemiology methicillin-susceptible methicillin-resistant S. (MRSA) among cystic fibrosis (CF) patients their household members.We sought to determine children adolescents with CF members.Three centers enrolled case subjects at least 1 MRSA-positive respiratory tract culture from 2001 2006 control MRSA-negative cultures. isolates anterior nares members were assessed for staphylococcal chromosomal cassette...
Summary Newborn screening for Cystic Fibrosis (CF) began in New York October, 2002 using immunoreactive trypsinogen (IRT)/DNA methodology. Infants with at least one CFTR mutation or very high IRT and no mutations (VHIRT) are referred sweat testing. In a preliminary analysis, we noted low positive predictive value (PPV) preponderance of Hispanic infants the group CF VHIRT, which led to decision revise, but not eliminate, VHIRT category. Automatic referral specimens collected on day birth was...
Abstract Background New York State (NYS) utilizes a three‐tiered cystic fibrosis newborn screening (CFNBS) algorithm that includes transmembrane conductance regulator ( CFTR ) gene sequencing. Infants with >1 variant of potential clinical relevance, including variants uncertain significance or varying consequence are referred for diagnostic evaluation at NYS (CF) Specialty Care Centers (SCCs). Aims As part ongoing quality improvement efforts, demographic, screening, diagnostic, and data...
Nearly all patients with cystic fibrosis (CF) have abnormal findings on plain paranasal sinus radiographs. To establish this relationship more accurately, 58 CF nasal symptoms were evaluated computed tomography (CT). Bilateral medial displacement of the lateral wall in middle meatus and uncinate process demineralization seen 43 (74%). Three (5%) had unilateral demineralization. Ten maxillary opacification, two (3.5%) unremarkable sinuses CT, another patient (2%) normal one side. Although...
Background: Elexacaftor/tezacaftor/ivacaftor (ETI) has reduced many symptoms of cystic fibrosis (CF). Objectives: We sought to identify the impact ETI on both and treatment decisions among adults with CF. Design: Participants were enrolled in a cross-sectional study. Surveys sent via RedCap link. Semistructured interviews administered remotely Microsoft Teams. Interviews audio recorded professionally transcribed. Methods: assessed Cystic Fibrosis Questionnaire-Revised (CFQ-R) subscales for...
Abstract Background Ventilator-associated tracheitis (VAT) is a common intensive-care unit entity considered in febrile patients with endotracheal intubation or tracheostomy. Prospective-Audit-And-Feedback activities had identified an overall increased and high inter-provider-variability the use of antibiotics for VAT. By developing VAT-specific guideline, we intended primarily to decrease amount respiratory fluid cultures (RFCx) submitted, secondly antibiotic (AU) PICU, while not increasing...