A5076252926- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Polyamine Metabolism and Applications
- Celiac Disease Research and Management
- Microbial Metabolites in Food Biotechnology
- Synthesis and biological activity
- Amino Acid Enzymes and Metabolism
- Synthesis and Characterization of Heterocyclic Compounds
- Gastroesophageal reflux and treatments
- Digestive system and related health
- Gastric Cancer Management and Outcomes
- Probiotics and Fermented Foods
- Diet, Metabolism, and Disease
- Synthesis and Catalytic Reactions
- Asymmetric Synthesis and Catalysis
- Microscopic Colitis
- Biopolymer Synthesis and Applications
- Veterinary medicine and infectious diseases
- Gut microbiota and health
- Metabolism and Genetic Disorders
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Analysis
- Nutritional Studies and Diet
- Eosinophilic Esophagitis
Gastroenterology Hospital "Saverio de Bellis"
2016-2025
Lundbeck (Denmark)
2024
Sapienza University of Rome
2024
University of Salento
2023
IRCCS Ospedale San Raffaele
2021-2022
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2021-2022
Advanced Micro Devices (Canada)
2022
University of Campania "Luigi Vanvitelli"
2021-2022
Federal Institute For Materials Research and Testing
2021
University of Florence
2001-2020
This Account summarizes predominately our own experiences in developing microwave-heated palladium-catalyzed Mo(CO)6-mediated gas-free carbonylative reactions, although contributions from other groups, including non-palladium-catalyzed examples, have also been covered. Presented reactions include amino-, amido-, and alkoxycarbonylations as well cyclizations cross-couplings, using Mo(CO)6 a solid source of CO. The methodology was developed mainly for rapid small-scale applications, avoiding...
Data from literature suggest the possible use of probiotics as chemopreventive agents against colon cancer, but few investigations are available on their effects gastric cancer proliferation. In our previous study, a specific Lactobacillus, strain L. paracasei IMPC2.1, was demonstrated to colonize human gut and positively affect fecal bacteria biochemical parameters. The aims present study were investigate comparing them with those Lactobacillus rhamnosus GG (L.GG), either viable or...
The goals of this study were to investigate the role a new probiotic preparation (Lactobacillus reuteri DSM 17938 and L. ATCC PTA 6475) in Helicobacter pylori infection.Specific strains play H. infection for their ability decrease bacterial load gastritis, prevent antibiotic-associated side effects, increase eradication rate.This is prospective, double-blind, randomized, placebo-controlled tertiary care setting. A total 100 pylori-positive naive patients received either combination (2×10...
Celiac disease is characterized by enhanced intestinal paracellular permeability due to alterations of function and expression tight junction (TJ) proteins including ZO-1, Claudin-1 Occludin. Polyamines are pivotal in the control barrier also involved regulation intercellular proteins. Different probiotic strains may inhibit gliadin-induced toxic effects Lactobacillus rhamnosus GG (L.GG) effective prevention treatment gastrointestinal diseases. Aims study were establish epithelial Caco-2...
Daily use of opioid analgesics has significantly increased in recent years due to an increasing prevalence conditions associated with chronic pain. Opioid-induced constipation (OIC) is one the most common, under-recognized, and under-treated side effects analgesics. OIC reduces quality life by causing psychological distress, lowering work productivity, access healthcare facilities. The economic social burden led development precise strategies for daily clinical practice. Key aspects are...
Alterations of the small-intestinal permeability (s-IP) might play an essential role in both diarrhoea-predominant IBS (D-IBS) and celiac disease (CD) patients. Our aims were to analyse D-IBS patients symptom profile along with levels urinary sucrose (Su), lactulose (La), mannitol (Ma), circulating biomarkers (zonulin, intestinal fatty acid binding protein - I-FABP, diamine oxidase DAO) gastrointestinal (GI) barrier function. The pro-inflammatory interleukins 6 8 (IL-6 IL-8), plasma values...
Decreased serum vitamin D (VD) levels have been associated with gastrointestinal (GI) disorders, including irritable bowel syndrome (IBS). VD can also modulate the intestinal barrier. Given link between GI barrier’s alterations and diet, attention has aroused positive effects of Low FODMAP Diet (LFD) on IBS patients’ symptom profile. We evaluated symptoms urinary circulating markers barrier function, inflammation dysbiosis in 36 patients predominant diarrhea (IBS-D) (5 men 31 women, 43.1 ±...
The very-low-calorie ketogenic diet (VLCKD) is effective and safe for obese individuals, but limited information exists on its impact the intestinal barrier. This study analyzed effects of 8 weeks VLCKD 24 patients (11M/13F). Carbohydrate intake was fixed at 20-50 g/day, while protein lipid varied from 1-1.4 g/kg ideal body weight 15-30 g per day, respectively. Daily calorie below 800 kcal. lactulose-mannitol absorption test assessed small permeability. Multiple markers, such as serum fecal...
Irritable bowel syndrome (IBS) involves low-grade mucosal inflammation. Among the various approaches capable of managing symptoms, physical activity is still under investigation. Despite its benefits, it promotes oxidative stress and Mitochondria impacts gut disorders by releasing damage-associated molecular patterns, such as cell-free mtDNA (cf-mtDNA), which support This study evaluated effects a 12-week walking program on cf-mtDNA DNase in 26 IBS 17 non-IBS subjects. Pro- anti-inflammatory...
Background : Predicting factors for the outcome of conventional Helicobacter pylori triple therapy have been identified. Of these, presence CagA gene is a strong predictor successful treatment. Our preliminary data show that this factor becomes irrelevant when sequential used. Aim To identify predicting H. eradication using two therapeutic schemes (triple and sequential) equal duration (10 days). Methods Ninety-six patients with infection were randomly assigned to receive one following...
Functional probiotics may prevent Helicobacter pylori infection, and some evidence suggests that they also possess antitumor properties. Lactobacillus brevis (CD2) is a functional strain with peculiar biochemical features, essentially related to the activity of arginine deiminase. This enzyme catalyzes catabolism affects biosynthesis polyamines (putrescine, spermidine, spermine). Polyamines are polycations found in high concentrations both normal neoplastic cells. Our aims were: 1, assess...
Different lines of evidence suggest that higher intake fiber may somehow protect against metabolic syndrome. The prebiotic inulin has widely been studied in relation to its putative beneficial effects on lipid and glucose metabolism. Therefore, adding diet be a suitable strategy prevent Aim the present study was evaluate daily consumption inulin-enriched pasta metabolism as well gastrointestinal motility young healthy subjects. Methods. Twenty-two male volunteers entered randomized double...
The concept of a nonresonant microwave applicator for continuous-flow organic chemistry is introduced and evaluated. frequency the incident radiation can be adjusted between 2.4 2.5 GHz to optimize energy absorbance. temperature reaction monitored by five IR sensors, their signals used automatically adjust power output from generator. heating several different solvents up 20 °C above standard boiling point has been explored. Several reactions have successfully carried out using 200 mm × ⌽ 3...
Celiac disease (CD) is a chronic immune-mediated disorder, characterized by enhanced paracellular permeability across the intestinal epithelium. The complex system of intercellular junctions, including tight junctions (TJs) and adherens (AJs), seals together epithelial cells to form continuous layer. improvements in barrier integrity have been related modifications junction protein expression. Polyamines (spermidine, spermine, putrescine) actively participate modulation AJ Both vitro vivo...
Accumulated evidence shows that some probiotic strains ameliorate functional constipation (FC) via the modulation of specific gastrointestinal peptide pathways. The aims this study were to investigate: (1) effects long-term administration Lactobacillus reuteri (LR) DSM 17938 on serum levels serotonin (5-HT) and brain-derived neurotrophic factor (BDNF); (2) possible link between 5-HT, BDNF, constipation-related symptoms; (3) whether genetic variability at 5-HTT gene-linked polymorphic region...
A very low calorie ketogenic diet (VLCKD) impacts host metabolism in people marked by an excess of visceral adiposity, and it affects the microbiota composition terms taxa presence relative abundances. As a matter fact, there is little available literature dealing with differences obese patients altered intestinal permeability. With aim inspecting consortium members their related metabolic pathways, we inspected microbial community profile, together set volatile organic compounds (VOCs) from...
Previous in vitro and vivo studies have suggested that lactobacilli can exert antiproliferative effects on the gastrointestinal epithelium. However, their role affecting cellular proliferative mechanisms is not completely clear. The aim of this study was to investigate increasing concentrations Lactobacillus rhamnosus strain GG (L. GG) homogenate cell growth proliferation (by MTT, [3H]-thymidine incorporation polyamine biosynthesis) neoplasms originating from different tracts. Thus, HGC-27...
Abstract Background Several GI peptides linked to intestinal barrier function could be involved in the modification of permeability and onset diarrhea during adjuvant chemotherapy. The aim study was evaluate circulating levels zonulin, glucagon-like peptide-2 (GLP-2), epidermal growth factor (EGF) ghrelin their relationship with chemotherapy induced (CTD). Methods Sixty breast cancer patients undergoing an FEC60 regimen were enrolled, 37 completed study. CTD(+) discriminated by appropriate...