In Brief Purpose: To evaluate the effects of intravitreal bevacizumab pretreatment in vitrectomy with silicone oil infusion for severe diabetic retinopathy. Methods: Forty-one eyes (39 patients) that underwent primary tamponade retinopathy were enrolled this prospective, comparative case–control clinical study. Cases alternately divided into following Group 1, (1.25 mg) injection 1 week before surgery; or 2, no injection. followed-up at least 6 months. Postinjection retinal changes, intra-...

To evaluate the efficacy of intravitreal bevacizumab with panretinal photocoagulation (PRP) in treatment proliferate diabetic retinopathy (PDR) vitreous hemorrhage (VH).Forty cases (40 patients) PDR and persistent VH were prospectively enrolled, a follow-up period 12 months or more. Intravitreal injection (1.25 mg) was given, followed by PRP when visualization peripheral fundus could be obtained. A second administered 4 weeks to 6 after first if no signs decrease noted. Vitrectomy performed...

This study investigated the therapeutic potential and mechanisms of chitosan oligosaccharides (COS) for oxidative stress-induced retinal diseases. Retinal damage was induced in Sprague-Dawley rats by intravitreal injection paraquat (PQ). Low-dose (5 mg/kg) or high-dose (10 COS PBS intragastrically given 14 days after PQ injection. Electroretinograms were performed to determine functionality retinas. The surviving neurons ganglion cell layer apoptosis determined counting Neu N-positive cells...

We investigated the surgical results of macular hole retinal detachment (MHRD) with a modified C-shaped temporal inverted internal limiting membrane (ILM) flap to reconstruct foveolar architecture in highly myopic eyes.Eighteen eyes MHRD 17 patients who underwent vitrectomy ILM were followed for 12 months. Anatomic outcomes evaluated by fundus examinations and optical coherence tomography. The preoperative postoperative best-corrected visual acuities (BCVAs) compared as functional...

Cysteine-rich 61 (Cyr61/CCN1) is reported to mediate angiogenesis. In this study, its role in ocular angiogenesis and proliferative diabetic retinopathy (PDR) was investigated.The effects of Cyr61 were evaluated by determining proliferation chemotaxis an assay capillary tube formation synthetic matrix chorioretinal endothelial cells (RF/6A). the same cells, expression under hypoxic conditions then investigated. Interactions between vascular growth factor (VEGF) examined using cell...

In Brief Purpose: To report clinical characteristics and treatment results of macular hole (MH) with diabetic fibrovascular proliferation. Methods: Twenty-three eyes 23 consecutive patients having surgery for proliferation MH were reviewed. Macular closure final visual acuity examined in relation to characteristics. Results: Traction combined retinal detachment was seen 17 cases 6 cases, respectively. Four had internal limiting membrane (ILM) peeling. closed 19 (82.6%) after surgery....

To assess the incidence and progression of diabetic retinopathy explore risk factors associated with them among non-insulin-dependent diabetes mellitus (NIDDM) patients. A total 471 NIDDM subjects aged >40 were recruited from four primary health care centres northern Taiwan in 1986 followed up for 4 years. Their ocular fundi clearly visible by ophthalmoscopy status could be graded. structured questionnaire Interview was conducted to collect basic data. Overnight fasting venous blood...

There are two main blood-ocular barriers, the blood-aqueous barrier and blood-retinal barrier. The is formed by nonpigmented ciliary epithelium of body vascular endothelium iris vessels. retinal vessels pigment epithelium. Four methods examination currently used to study function barriers. Among these, laser flare-cell photometry a noninvasive, quantitative method evaluate permeability Vitreous fluorophotometry an excellent technique quantitate function. Fluorescein angiography optical...

To investigate the microstructural characteristics of lattice degenerations before and after laser photocoagulation in myopic eyes by spectral-domain optical coherence tomography (SD-OCT).Twenty-five 25 consecutive patients at High Myopia Clinic National Taiwan University Hospital were retrospectively reviewed. Myopic with peripheral degeneration enrolled study. Best-corrected visual acuity (BCVA), axial length measurement, color fundus photography was performed. SD-OCT analyses on performed...

Purpose: This study aimed to evaluate treatment effects of intravitreal gas for macular hole with localized retinal detachment (RD) in highly myopic eyes and examine how the vitreomacular relationship other factors may influence outcomes. Methods: Twenty patients holes posterior RD, treated initially injection C3F8, were prospectively studied. Recurrent disease was repeated or vitrectomy according extent detachment. Length follow-up ≥ 12 months. Vitreomacular conditions determined before...

Corneal autofluorescence and corneal epithelial barrier function of 146 diabetic patients 121 controls were examined using anterior segment fluorophotometry. in was significantly higher when compared with that (14.6 +/- 3.7 vs. 10.9 2.7 ng/ml, p < 0.001), increased more severe retinopathy (r = 0.23, 0.005), postprandial blood glucose level 0.25, 0.009), glycosylated hemoglobin 0.21, 0.047). No correlation existed between the duration diabetes mellitus. The fluorescein concentration 45 min...

Corneal small leucine-rich proteoglycans play a pivotal role in maintaining corneal transparency and function. In this study, we isolated characterized the zebrafish (Danio rerio) keratocan (zKera) gene. The human sequence was used to search homologues. zKera full-length genomic DNA cDNA were generated via PCR of reverse transcription-PCR total eye RNA, respectively. spanning 3.5 kilobase pairs consists two exons one intron TATA-less promoter. encodes 341 amino acids with 59% identity its...